scholarly journals Neuregulin-1 exerts molecular control over axolotl lung regeneration through ErbB family receptors

2018 ◽  
Author(s):  
Tyler B Jensen ◽  
Peter Giunta ◽  
Natalie Grace Schulz ◽  
Yaa Kyeremateng ◽  
Hilary Wong ◽  
...  
Keyword(s):  
Proliferative Response ◽  
Model Organism ◽  
Ambystoma Mexicanum ◽  
Limb Amputation ◽  
Compensatory Mechanism ◽  
Molecular Control ◽  
Neuregulin 1 ◽  
Erbb4 Receptor ◽  
Erbb Signaling ◽  
Lung Regeneration

ABSTRACTThe induction of new lung tissue after disease or trauma has the potential to save lives and transform patient outcomes. Ambystoma mexicanum, the axolotl salamander, is a classic model organism used to study vertebrate regeneration, primarily after limb amputation. While it is hypothesized that axolotls regenerate all of their tissues, exploration of lung regeneration has not been performed until now. Proliferation after lung injury was observed to be a global response, suggesting that regeneration utilizes a compensatory mechanism, in contrast to limb regeneration’s epimorphic response. ErbB signaling is crucial for the proliferative response during lung regeneration, likely through the ErbB2:ErbB4 receptor heterodimer. ErbB4 mRNA was found to be highly upregulated at both one and three weeks post amputation. Neuregulin-1p (NRG1) can induce proliferation in the lung and likely exerts molecular control over lung regeneration. Inhibition of ErbB2 was sufficient to both block regeneration and the proliferative response observed after NRG1 treatment.

scholarly journals Role of Neuregulin-1/ErbB Signaling in Stem Cell Therapy for Spinal Cord Injury-Induced Chronic Neuropathic Pain

Stem Cells ◽  
2012 ◽  
Vol 31 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Feng Tao ◽  
Qun Li ◽  
Su Liu ◽  
Haiying Wu ◽  
John Skinner ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Stem Cell ◽  
Cell Therapy ◽  
Chronic Neuropathic Pain ◽  
Neuregulin 1 ◽  
Cord Injury ◽  
Erbb Signaling

scholarly journals Recently Approved and Under Investigation Drugs for Treating Patients with Heart Failure

2020 ◽  
Vol 16 (3) ◽  
pp. 202-211
Author(s):  
Yaniel Castro-Torres ◽  
Richard E. Katholi
Keyword(s):  
Heart Failure ◽  
Clinical Practice ◽  
Mineralocorticoid Receptor ◽  
Sodium Current ◽  
Mineralocorticoid Receptor Antagonists ◽  
Neuregulin 1 ◽  
Reduced Ejection Fraction ◽  
Vasoactive Peptides ◽  
Patients With Heart Failure ◽  
Erbb Signaling

: Heart Failure (HF) represents a leading cause of morbidity and mortality worldwide. Despite the recent advances in the treatment of this condition, patients´ prognosis remains unfavorable in most cases. Sacubitril/valsartan and ivabradine have been recently approved to improve clinical outcomes in patients with HF with reduced ejection fraction. Drugs under investigation for treating patients with HF encompass many novel mechanisms including vasoactive peptides, blocking inflammatory- mediators, natriuretic peptides, selective non-steroidal mineralocorticoid-receptor antagonists, myocardial β3 adrenoreceptor agonists, inhibiting the cytochrome C/cardiolipin peroxidase complex, neuregulin-1/ErbB signaling and inhibiting late inward sodium current. The aim of this manuscript is to review the main drugs under investigation for the treatment of patients with HF and give perspectives for their implementation into clinical practice.

Abstract 352: Myocardial Neuregulin-1/ErbB Signaling Is Impaired in the Setting of Post--Myocardial Infarction Heart Failure Complicated by Type 1 Diabetes Mellitus

2012 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
Oghenerukevwe Odiete ◽  
Kathleen E Dennis ◽  
Douglas B Sawyer ◽  
Michael F Hill
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Heart Failure ◽  
Type 1 Diabetes ◽  
Protein Expression ◽  
Type 1 Diabetes Mellitus ◽  
Neuregulin 1 ◽  
Erbb Signaling ◽  
Type 1 Dm

Background: Type 1 diabetes mellitus (DM) patients surviving myocardial infarction (MI) are at heightened risk for the subsequent development of heart failure (HF). Despite the worse outcomes, investigations into the pathophysiological mechanisms that contribute to the increased frequency of HF after MI in the type 1 DM heart remain scarce. Neuregulin-1 (NRG-1), along with the ErbB family of receptor tyrosine kinases through which NRG-1 ligands signal, have been shown to be intimately involved in mediating cardiac recovery after MI. However, the impact of type 1 DM on this signaling system post-MI remains to be elucidated. Therefore, in the present study, we examined myocardial NRG-1/ErbB signaling during post-MI HF in the presence of type 1 DM. Methods: Type 1 DM was induced in male Sprague-Dawley rats via a single intraperitoneal injection of streptozotocin (STZ) (65 mg/kg). Two weeks after induction of type 1 DM, MI was produced in DM and non-DM rats by ligation of the left anterior descending (LAD) coronary artery. Residual left ventricular (LV) function was assessed by echocardiography at 4 weeks post-MI. Following echocardiographic assessment, NRG-1, ErbB2, and ErbB4 protein expression was assessed in the remote, surviving LV myocardium of DM and non-DM rats using Western blot techniques. Results: LV Fractional Shortening (FS) and LV Ejection Fraction (EF) were significantly lower in the DM + MI group compared to the MI group ([LVFS: DM + MI, 17.9 ± 0.7 (n=6) vs. MI, 25.2 ± 2.2 (n=6), p <0.05; LVEF: DM + MI, 35.5 ± 1.4 (n=6) vs. MI, 47.5 ± 3.5 (n=6), p <0.05]), indicating an increased functional severity of HF in the diabetic post-MI group. The weight of myocardial scar caused by the infarction was not significantly different between the MI groups ([DM + MI, 0.19 ± 0.02 g (n=4) vs. MI, 0.20 ± 0.03 g (n=4), p =0.70]). ErbB2, ErbB4, and NRG-1 protein expression levels were all significantly lower in the DM + MI group compared to the MI group. Conclusions: These findings demonstrate that type 1 DM impairs myocardial NRG-1/ErbB signaling in response to MI, which may contribute to the accelerated progression of subsequent HF. Augmentation of NRG-1 or its downstream signaling pathways may represent a novel therapeutic strategy for ameliorating post-MI HF in the setting of type 1 DM.

Neuregulin‐1‐ErbB signaling promotes microglia activation contributing to mechanical allodynia of cyclophosphamide‐induced cystitis

2019 ◽  
Vol 38 (5) ◽  
pp. 1250-1260 ◽  
Author(s):  
Jia‐Liang Chen ◽  
Xin Zhou ◽  
Hong‐Lu Ding ◽  
Hai‐Lun Zhan ◽  
Fei Yang ◽  
...  
Keyword(s):  
Mechanical Allodynia ◽  
Microglia Activation ◽  
Neuregulin 1 ◽  
Erbb Signaling

scholarly journals Neuregulin 1 Type III/ErbB Signaling Is Crucial for Schwann Cell Colonization of Sympathetic Axons

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28692 ◽  
Author(s):  
Stephan Heermann ◽  
Julia Schmücker ◽  
Ursula Hinz ◽  
Michael Rickmann ◽  
Tilmann Unterbarnscheidt ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Neuregulin 1 ◽  
Type Iii ◽  
Erbb Signaling ◽  
Cell Colonization

scholarly journals The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development

2009 ◽  
Vol 106 (39) ◽  
pp. 16704-16709 ◽  
Author(s):  
K. S. Grossmann ◽  
H. Wende ◽  
F. E. Paul ◽  
C. Cheret ◽  
A. N. Garratt ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Tyrosine Phosphatase ◽  
Cell Development ◽  
Neuregulin 1 ◽  
Erbb Signaling ◽  
Schwann Cell Development

scholarly journals Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0166710 ◽  
Author(s):  
Taku Yasui ◽  
Takeshi Masaki ◽  
Yoh Arita ◽  
Tomohiko Ishibashi ◽  
Tadakatsu Inagaki ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Striated Muscle ◽  
Signal Transducer ◽  
Critical Signal ◽  
Neuregulin 1 ◽  
Erbb Signaling

scholarly journals Experimentally Induced Metamorphosis in Axolotl (Ambystoma mexicanum) Under Constant Diet Restructures Microbiota Accompanied by Reduced Limb Regenerative Capacity

2018 ◽  
Author(s):  
Turan Demircan ◽  
Guvanch Ovezmyradov ◽  
Berna Yıldırım ◽  
İlknur Keskin ◽  
Ayse Elif İlhan ◽  
...  
Keyword(s):  
Model Organism ◽  
Fecal Microbiota ◽  
Ambystoma Mexicanum ◽  
Rrna Gene ◽  
Regenerative Capacity ◽  
Experimental Procedure ◽  
Bacterial Microbiota ◽  
Major Transition ◽  
Salamander Species ◽  
Experimentally Induced

AbstractAxolotl (Ambystoma mexicanum) is a critically endangered salamander species and a model organism for regenerative and developmental biology. Despite life-long neoteny in nature and in captive-bred colonies, metamorphosis of these animals can be experimentally induced by administering Thyroid hormones (THs). However, biological consequences of this experimental procedure, such as host microbiota response and implications for regenerative capacity, remain largely unknown. Here, we systematically compared host bacterial microbiota associated with skin, stomach, gut tissues and fecal samples based on 16S rRNA gene sequences, along with limb regenerative capacity, between neotenic and metamorphic Axolotls. Our results show that distinct bacterial communities inhabit individual organs of Axolotl and undergo substantial restructuring through metamorphosis. Drastic restructuring was observed for skin microbiota, highlighted by a major transition from Firmicutes-enriched to Proteobacteria-enriched relative abundance and precipitously decreased diversity. Remarkably, shifts in microbiota was accompanied by a steep reduction in limb regenerative capacity. Fecal microbiota of neotenic and metamorphic Axolotl shared relatively higher similarity, suggesting that diet continues to shape microbiota despite fundamental transformations in the host digestive organs. The results provide novel insights into microbiological and regenerative aspects of Axolotl metamorphosis and will establish a baseline for future in-depth studies.

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