Characterization of DNA hydroxymethylation in hypothalamus of elderly mice with postoperative cognitive dysfunction

2018 ◽  
Author(s):  
Jiang Zhong ◽  
Xu Wei
Keyword(s):  
Dna Methylation ◽  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
Memory Loss ◽  
The Elderly ◽  
Amygdaloid Nucleus ◽  
Dna Hydroxymethylation ◽  
And Control ◽  
With Memory

Postoperative cognitive dysfunction (POCD) is a common syndrome with perioperative cerebral damage in elderly patients, displaying cognitive impairment and memory loss. Current studies revealed that anesthesia is one of the important causes for POCD occurrence. Recently, Ubiquitin-like with PHD and Ring Figner Domains 2 (Uhrf2) has been reported to play a crucial role in regulating DNA methylation and hydroxymethylation, which are closely connected with memory building and erasure. However, whether narcotic drugs can affect Uhrf2 to impact on DNA methylation and hydroxymethylation in POCD is poorly understood. In this study, we established the elderly POCD mouse model through treatment with sevoflurane, and observed the global DNA hydroxymethylated cytosine (5hmC) distribution alteration in hippocampus, amygdaloid nucleus and cerebellum compared to non-POCD and control. Furthermore, we also found that the expression of Uhrf2 was coincident with 5hmC change in different regions of brain. Finally, we observed that the 5hmC enrichment on the promoters of some important genes for neural protection and development, such as GDNF, BDNF, GCR, ACSS2 were down-regulated upon POCD. Taken together, we determine that anesthetic may result in the loss of global 5hmC through Uhrf2 suppression in brain and thereby impair the learning and memory ability for POCD occurrence.

scholarly journals Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction

2019 ◽  
Vol 129 (5) ◽  
pp. e150-e154 ◽  
Author(s):  
Miles Berger ◽  
David M. Murdoch ◽  
Janet S. Staats ◽  
Cliburn Chan ◽  
Jake P. Thomas ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Cerebrospinal Fluid ◽  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction

Cognitive dysfunction and sleep disorders

2017 ◽  
Author(s):  
Chris Dodds ◽  
Chandra M. Kumar ◽  
Frédérique Servin
Keyword(s):  
Cognitive Dysfunction ◽  
Inflammatory Responses ◽  
Postoperative Cognitive Dysfunction ◽  
The Elderly ◽  
Sleep Apnoea ◽  
Sleep Stages ◽  
Anticholinergic Drugs ◽  
Obstructive Sleep ◽  
Patient’S History ◽  
The Impact

Cognitive dysfunction is largely a problem in the elderly, but it can occur at any age. The two major presentations, delirium and postoperative cognitive dysfunction (POCD), are compared. Risks for delirium are explored; key points from the patient’s history and possible ways to ameliorate the onset are then reviewed. The presentation of POCD is described, and the lack of our understanding of its causes is highlighted. Known triggers such as centrally active anticholinergic drugs or pain are identified. Current thinking in the inflammatory responses within microglia and astrocytes is summarized. Sleep in the elderly is contrasted with that in younger persons, and the main stages of sleep, SWS and REM, described. The impact and importance of the effects that surgery/anaesthesia has on sleep stages is reviewed. Obstructive sleep apnoea is described, including its effect on the safety of anaesthesia and recovery. Periodic limb movement disorders and early Parkinson disease are described.

Postoperative cognitive dysfunction in the elderly

The Lancet ◽  
1998 ◽  
Vol 351 (9119) ◽  
pp. 1889 ◽  
Author(s):  
Jakob Trier Moller ◽  
Lars S Rasmussen ◽  
Chris Hanning
Keyword(s):  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
The Elderly

scholarly journals MiR-190a Potentially Ameliorates Postoperative Cognitive Dysfunction by Regulating Tiam1

2019 ◽  
Author(s):  
Qiang Liu ◽  
Aisheng Hou ◽  
Yongyi Zhang ◽  
Ying Guo ◽  
Jingjing Li ◽  
...  
Keyword(s):  
Network Analysis ◽  
Cognitive Dysfunction ◽  
Binding Sites ◽  
Postoperative Cognitive Dysfunction ◽  
The Elderly ◽  
Mirna Microarray ◽  
Post Surgery ◽  
Highly Correlated ◽  
Microarray Datasets ◽  
Predictive Indicator

Abstract Postoperative cognitive dysfunction (POCD) affects a large number of post-surgery patients, especially for the elderly. However, the etiology of this neurocognitive disorder is largely unknown. Even if several studies have reported a small number of miRNAs as the essential modulatory factors in POCD, these findings are still rather limited. In this study, we used two miRNA microarray datasets to perform differential expression analyses of miRNAs in the hippocampus of POCD model mice. We found that nine miRNAs showed significant associations with POCD in both datasets. Among these miRNAs, mmu-miR-190a-3p was the most significant one. By performing weighted gene co-expression network analysis, we found 25 co-expression modules, of which mmu-miR-190a-3p was significantly anti-correlated with the red module. Moreover, in this red module, 314 genes were significantly enriched in four pathways such as axon guidance and calcium signaling pathway, which are well-documented to be associated with psychiatric disorders and brain development. Also, 169 of the 314 genes were highly correlated with mmu-miR-190a-3p, and four genes (Sphkap, Arhgef25, Tiam1, and Ntrk3) had putative binding sites at 3'-UTR of mmu-miR-190a-3p. Based on protein-protein network analysis, we detected that Tiam1 was a central gene regulated by the mmu-miR-190a-3p. Taken together, we conclude that mmu-miR-190a-3p is involved in the etiology of POCD and may serve as a novel predictive indicator for POCD.

scholarly journals MiR-190a Potentially Ameliorates Postoperative Cognitive Dysfunction by Regulating Tiam1

2019 ◽  
Author(s):  
Qiang Liu ◽  
Aisheng Hou ◽  
Yongyi Zhang ◽  
Ying Guo ◽  
Jingjing Li ◽  
...  
Keyword(s):  
Network Analysis ◽  
Cognitive Dysfunction ◽  
Binding Sites ◽  
Postoperative Cognitive Dysfunction ◽  
The Elderly ◽  
Mirna Microarray ◽  
Post Surgery ◽  
Highly Correlated ◽  
Microarray Datasets ◽  
Predictive Indicator

Abstract Postoperative cognitive dysfunction (POCD) affects a large number of post-surgery patients, especially for the elderly. However, the etiology of this neurocognitive disorder is largely unknown. Even if several studies have reported a small number of miRNAs as the essential modulatory factors in POCD, these findings are still rather limited. In this study, we used two miRNA microarray datasets to perform differential expression analyses of miRNAs in the hippocampus of POCD model mice. We found that nine miRNAs showed significant associations with POCD in both datasets. Among these miRNAs, mmu-miR-190a-3p was the most significant one. By performing weighted gene co-expression network analysis, we found 25 co-expression modules, of which mmu-miR-190a-3p was significantly anti-correlated with the red module. Moreover, in this red module, 314 genes were significantly enriched in four pathways such as axon guidance and calcium signaling pathway, which are well-documented to be associated with psychiatric disorders and brain development. Also, 169 of the 314 genes were highly correlated with mmu-miR-190a-3p, and four genes (Sphkap, Arhgef25, Tiam1, and Ntrk3) had putative binding sites at 3'-UTR of mmu-miR-190a-3p. Based on protein-protein network analysis, we detected that Tiam1 was a central gene regulated by the mmu-miR-190a-3p. Taken together, we conclude that mmu-miR-190a-3p is involved in the etiology of POCD and may serve as a novel predictive indicator for POCD.

scholarly journals Can Intraoperative Processed EEG Predict Postoperative Cognitive Dysfunction in the Elderly?

2015 ◽  
Vol 37 (12) ◽  
pp. 2700-2705 ◽  
Author(s):  
Stacie Deiner ◽  
Xiaodong Luo ◽  
Jeffrey H. Silverstein ◽  
Mary Sano
Keyword(s):  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
The Elderly ◽  
Processed Eeg
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