scholarly journals Few Effects of a 5-week Computerized Cognitive Training Program in Healthy Older Adults

2019 ◽  
Author(s):  
Sheida Rabipour ◽  
Cassandra Morrison ◽  
Jessica Crompton ◽  
Marcelo Petrucelli ◽  
Murillo de Oliveira Gonçalves Germano ◽  
...  

AbstractComputerized cognitive training programs are becoming increasingly popular and practical for cognitive aging. Nevertheless, basic questions remain about the benefits of such programs, and about the degree to which participant expectations might influence training and transfer. Here we examined a commercial cognitive training program (Activate) in a 5-week double-blind, pseudo-randomized placebo-controlled trial. Based on a priori power analysis, we recruited 99 healthy older adults 59-91 years of age (M = 68.87, SD = 6.31; 69 women), assigning them to either the intervention or an active control program (Sudoku and n-back working memory exercises). We subdivided both groups into high and low expectation priming conditions, to probe for effects of participants’ expectations on training and transfer. We assessed transfer using a battery of standard neuropsychological and psychosocial measures that had been agreed to by the training program developers. We planned and pre-registered our analyses (on osf.io). The majority (88%) of participants progressed through the training, and most provided positive feedback about it. Similarly, the majority (80%) of participants believed they were truly training their brains. Yet, transfer of training was minimal. Also minimal were any effects of expectations on training and transfer, although participants who received high expectation priming tended to engage more with their assigned program overall. Our findings suggest limited benefits ofActivatetraining on cognition and psychosocial wellbeing in healthy older adults, at least under the conditions we used.

2019 ◽  
Vol 4 (3) ◽  
pp. 258-273
Author(s):  
Sheida Rabipour ◽  
Cassandra Morrison ◽  
Jessica Crompton ◽  
Marcelo Petrucelli ◽  
Murillo de Oliveira Gonçalves Germano ◽  
...  

2017 ◽  
Vol 5 ◽  
pp. 1032-1035
Author(s):  
Antonia Yaneva ◽  
Nonka Mateva

Cognitive interventions, especially cognitive training, may improve cognitive functions in healthy older adults. Computerized cognitive training platforms offer several advantages over traditional programs for cognitive training and stimulation. The focus of this article is the methodology of the studies that apply a particular online training program. We investigate the effectiveness of several studies for cognitive training in healthy elderly people and evaluate reported outcomes and potential bias and what factors determine, influence or contribute to the positive or negative results. The post-intervention scores demonstrate that computerized cognitive training may enhance some cognitive functions and the overall cognitive status but there is need for additional research to prove its effectiveness.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Alexander V. Lebedev ◽  
Jonna Nilsson ◽  
Joanna Lindström ◽  
William Fredborg ◽  
Ulrika Akenine ◽  
...  

AbstractCognitive aging creates major individual and societal burden, motivating search for treatment and preventive care strategies. Behavioural interventions can improve cognitive performance in older age, but effects are small. Basic research has implicated dopaminergic signalling in plasticity. We investigated whether supplementation with the dopamine-precursor L-dopa improves effects of cognitive training on performance. Sixty-three participants for this randomised, parallel-group, double-blind, placebo-controlled trial were recruited via newspaper advertisements. Inclusion criteria were: age of 65–75 years, Mini-Mental State Examination score >25, absence of serious medical conditions. Eligible subjects were randomly allocated to either receive 100/25 mg L-dopa/benserazide (n = 32) or placebo (n = 31) prior to each of twenty cognitive training sessions administered during a four-week period. Participants and staff were blinded to group assignment. Primary outcomes were latent variables of spatial and verbal fluid intelligence. Compared to the placebo group, subjects receiving L-dopa improved less in spatial intelligence (−0.267 SDs; 95%CI [−0.498, −0.036]; p = 0.024). Change in verbal intelligence did not significantly differ between the groups (−0.081 SDs, 95%CI [−0.242, 0.080]; p = 0.323). Subjects receiving L-dopa also progressed slower through the training and the groups displayed differential volumetric changes in the midbrain. No statistically significant differences were found for the secondary cognitive outcomes. Adverse events occurred for 10 (31%) and 7 (23%) participants in the active and control groups, correspondingly. The results speak against early pharmacological interventions in older healthy adults to improve broader cognitive functions by targeting the dopaminergic system and provide no support for learning-enhancing properties of L-dopa supplements in the healthy elderly. The findings warrant closer investigation about the cognitive effects of early dopamine-replacement therapy in neurological disorders. This trial was preregistered at the European Clinical Trial Registry, EudraCT#2016-000891-54 (2016-10-05).


Sign in / Sign up

Export Citation Format

Share Document