scholarly journals Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

2019 ◽  
Author(s):  
Todd M. Everson ◽  
Marta Vives-Usano ◽  
Emie Seyve ◽  
Andres Cardenas ◽  
Marina Lacasaña ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Birth Outcomes ◽  
Fetal Growth ◽  
Maternal Smoking ◽  
Meta Analysis ◽  
Growth Factor Signaling ◽  
Hormone Activity ◽  
Smoking During Pregnancy ◽  
Placental Function ◽  
Maternal Smoking During Pregnancy

AbstractMaternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. We meta-analyzed the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (7 studies, N=1700, 344 with any MSDP). We identified 1224 CpGs that were associated with MSDP, of which 341 associated with birth outcomes and 141 associated with gene expression. Only 6 of these CpGs were consistent with the findings from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP associated CpGs were enriched for growth-factor signaling, hormone activity, inflammation, and vascularization, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.

scholarly journals Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Todd M. Everson ◽  
Marta Vives-Usano ◽  
Emie Seyve ◽  
Andres Cardenas ◽  
Marina Lacasaña ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Birth Outcomes ◽  
Fetal Growth ◽  
Maternal Smoking ◽  
Meta Analysis ◽  
Growth Factor Signaling ◽  
Environmental Response ◽  
Smoking During Pregnancy ◽  
Placental Function ◽  
Maternal Smoking During Pregnancy

AbstractMaternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.

Maternal smoking during pregnancy and the risk of strabismus in offspring: a meta‐analysis

2018 ◽  
Vol 97 (4) ◽  
pp. 353-363 ◽  
Author(s):  
Yudi Yang ◽  
Chao Wang ◽  
Yong Gan ◽  
Heng Jiang ◽  
Wenning Fu ◽  
...  
Keyword(s):  
Maternal Smoking ◽  
Meta Analysis ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals Maternal smoking during pregnancy is associated with mitochondrial DNA methylation

2016 ◽  
Vol 2 (3) ◽  
pp. dvw020 ◽  
Author(s):  
David A. Armstrong ◽  
Benjamin B. Green ◽  
Bailey A. Blair ◽  
Dylan J. Guerin ◽  
Julia F. Litzky ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring

2015 ◽  
Vol 44 (4) ◽  
pp. 1224-1237 ◽  
Author(s):  
Leanne K Küpers ◽  
Xiaojing Xu ◽  
Soesma A Jankipersadsing ◽  
Ahmad Vaez ◽  
Sacha la Bastide-van Gemert ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals Maternal smoking during pregnancy and offspring body mass index and overweight: a systematic review and meta-analysis

2019 ◽  
Vol 35 (12) ◽  
Author(s):  
Elma Izze da Silva Magalhães ◽  
Bruno Andrade de Sousa ◽  
Natália Peixoto Lima ◽  
Bernardo Lessa Horta
Keyword(s):  
Systematic Review ◽  
Body Mass Index ◽  
Body Mass ◽  
Maternal Smoking ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Mean Difference ◽  
Smoking During Pregnancy ◽  
Smoking In Pregnancy ◽  
Maternal Smoking During Pregnancy

Abstract: The present study aimed to conduct a systematic review and meta-analysis to evaluate the evidence on the association of maternal smoking during pregnancy with offspring body composition in childhood, adolescence and adulthood. MEDLINE, Web of Science and LILACS databases were searched. Reference lists were also screened. We included original studies, conducted in humans, that assessed the association of maternal smoking during pregnancy with offspring body mass index (BMI) and overweight in childhood, adolescence and adulthood, published through May 1st, 2018. A meta-analysis was used to estimate pooled effect sizes. The systematic review included 64 studies, of which 37 evaluated the association of maternal smoking during pregnancy with overweight, 13 with BMI, and 14 evaluated both outcomes. Of these 64 studies, 95 measures of effect were extracted and included in the meta-analysis. We verified that the quality of evidence across studies regarding maternal smoking in pregnancy and overweight and BMI of offspring to be moderate and low, respectively. Most studies (44 studies) were classified as moderate risk bias. Heterogeneity among studies included was high and, in the random-effects pooled analysis, maternal smoking during pregnancy increased the odds of offspring overweight (OR: 1.43, 95%CI: 1.35; 1.52) and mean difference of BMI (β: 0.31, 95%CI: 0.23; 0.39). In conclusion, offspring of mothers who smoked during pregnancy have higher odds of overweight and mean difference of BMI, and these associations persisted into adulthood.

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