scholarly journals Constant Infusion Radiotracer Administration for High Temporal Resolution Positron Emission Tomography (PET) of the Human Brain: Application to [18F]-Fluorodexoyglucose PET (FDG-PET)

2019 ◽  
Author(s):  
Sharna D Jamadar ◽  
Phillip GD Ward ◽  
Alexandra Carey ◽  
Richard McIntyre ◽  
Linden Parkes ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Human Brain ◽  
Temporal Resolution ◽  
Fdg Pet ◽  
Blood Oxygenation ◽  
Emission Tomography ◽  
Constant Infusion ◽  
High Temporal Resolution ◽  
Bolus Administration ◽  
Positron Emission

AbstractFunctional Positron Emission Tomography (fPET) provides a method to track molecular dynamics in the human brain. With a radioactively labelled glucose-analogue, [18F]-flurodeoxyglucose (FDG-fPET), it is now possible to index the dynamics of glucose metabolism with temporal resolutions approaching those of functional magnetic resonance imaging (fMRI). This direct measure of glucose uptake has enormous potential for understanding normal and abnormal brain function, and probing the effects of metabolic and neurodegenerative diseases. Further, new advances in hybrid MR-PET hardware makes it possible to capture fluctuations in glucose and blood oxygenation simultaneously using fMRI and FDG-fPET.The temporal resolution and signal-to-noise of the FDG-fPET images is critically dependent upon the administration of the radioactive tracer. In this work we present two alternative continuous infusion protocols and compare them to a traditional bolus approach. We detail a method for acquiring blood samples, time-locking PET, MRI and experimental stimulus, and administrating the non-traditional tracer delivery. By applying a visual stimulus, we demonstrate cortical maps of the glucose-response to external stimuli on an individual level with a temporal resolution of 16-seconds.SummaryRadiotracer infusion protocols for positron emission tomography (PET) provide improved temporal resolution over bolus administration. Here, we describe radiotracer administration for two protocols, constant infusion and bolus plus infusion protocol. We compare this to the standard bolus administration protocol. Using [18-F] fluorodeoxyglucose PET (FDG-PET) as an example, we show that temporal resolutions of approximately 16sec are achievable using these protocols.

Metabolic and Hemodynamic Resting-State Connectivity of the Human Brain: A High-Temporal Resolution Simultaneous BOLD-fMRI and FDG-fPET Multimodality Study

2021 ◽  
Author(s):  
Sharna D Jamadar ◽  
Phillip G D Ward ◽  
Emma X Liang ◽  
Edwina R Orchard ◽  
Zhaolin Chen ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Human Brain ◽  
Temporal Resolution ◽  
Fdg Pet ◽  
Brain Connectivity ◽  
Emission Tomography ◽  
High Temporal Resolution ◽  
Positron Emission ◽  
Metabolic Connectivity ◽  
The Brain

Abstract Simultaneous [18F]-fluorodeoxyglucose positron emission tomography functional magnetic resonance imaging (FDG-PET/fMRI) provides the capacity to image 2 sources of energetic dynamics in the brain—glucose metabolism and the hemodynamic response. fMRI connectivity has been enormously useful for characterizing interactions between distributed brain networks in humans. Metabolic connectivity based on static FDG-PET has been proposed as a biomarker for neurological disease, but FDG-sPET cannot be used to estimate subject-level measures of “connectivity,” only across-subject “covariance.” Here, we applied high-temporal resolution constant infusion functional positron emission tomography (fPET) to measure subject-level metabolic connectivity simultaneously with fMRI connectivity. fPET metabolic connectivity was characterized by frontoparietal connectivity within and between hemispheres. fPET metabolic connectivity showed moderate similarity with fMRI primarily in superior cortex and frontoparietal regions. Significantly, fPET metabolic connectivity showed little similarity with FDG-sPET metabolic covariance, indicating that metabolic brain connectivity is a nonergodic process whereby individual brain connectivity cannot be inferred from group-level metabolic covariance. Our results highlight the complementary strengths of fPET and fMRI in measuring the intrinsic connectivity of the brain and open up the opportunity for novel fundamental studies of human brain connectivity as well as multimodality biomarkers of neurological diseases.

scholarly journals Metabolic and haemodynamic resting-state connectivity of the human brain: a high-temporal resolution simultaneous BOLD-fMRI and FDG-fPET multimodality study

2020 ◽  
Author(s):  
Sharna D Jamadar ◽  
Phillip GD Ward ◽  
Emma Xingwen Liang ◽  
Edwina R Orchard ◽  
Zhaolin Chen ◽  
...  
Keyword(s):  
Human Brain ◽  
Temporal Resolution ◽  
Fdg Pet ◽  
Neurological Diseases ◽  
Brain Connectivity ◽  
Constant Infusion ◽  
High Temporal Resolution ◽  
Positron Emission ◽  
Metabolic Connectivity ◽  
The Brain

AbstractSimultaneous FDG-PET/fMRI ([18F]-fluorodeoxyglucose positron emission tomography functional magnetic resonance imaging) provides the capacity to image two sources of energetic dynamics in the brain – glucose metabolism and haemodynamic response. Functional fMRI connectivity has been enormously useful for characterising interactions between distributed brain networks in humans. Metabolic connectivity based on static FDG-PET has been proposed as a biomarker for neurological disease; but static FDG-PET cannot be used to estimate subjectlevel measures of connectivity, only across-subject covariance. Here, we applied high-temporal resolution constant infusion fPET to measure subject-level metabolic connectivity simultaneously with fMRI connectivity. fPET metabolic connectivity was characterised by fronto-parietal connectivity within and between hemispheres. fPET metabolic connectivity showed moderate similarity with fMRI primarily in superior cortex and frontoparietal regions. Significantly, fPET metabolic connectivity showed little similarity with static FDG-PET metabolic covariance, indicating that metabolic brain connectivity is a non-ergodic process whereby individual brain connectivity cannot be inferred from group level metabolic covariance. Our results highlight the complementary strengths of fPET and fMRI in measuring the intrinsic connectivity of the brain, and open up the opportunity for novel fundamental studies of human brain connectivity as well as multi-modality biomarkers of neurological diseases.

scholarly journals Monash DaCRA fPET-fMRI: A DAtaset for Comparison of Radiotracer Administration for high temporal resolution functional FDG-PET

2021 ◽  
Author(s):  
Sharna D Jamadar ◽  
Emma X Liang ◽  
Shenjun Zhong ◽  
Phillip GD Ward ◽  
Alexandra Carey ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Glucose Uptake ◽  
Temporal Resolution ◽  
Emission Tomography ◽  
Constant Infusion ◽  
High Temporal Resolution ◽  
Bolus Infusion ◽  
Bold Fmri ◽  
Infusion Group ◽  
Positron Emission

Background: Functional [18F]-fluorodeoxyglucose positron emission tomography (FDG-fPET) is a new approach for measuring glucose uptake in the human brain. The goal of FDG-fPET is to maintain a constant plasma supply of radioactive FDG in order to track, with high temporal resolution, the dynamic uptake of glucose during neuronal activity that occurs in response to a task or at rest. FDG-fPET has most often been applied in simultaneous BOLD-fMRI/FDG-fPET (blood oxygenation level dependent functional MRI fluorodeoxyglucose functional positron emission tomography) imaging. BOLD-fMRI/FDG-fPET provides the capability to image the two primary sources of energetic dynamics in the brain, the cerebrovascular haemodynamic response and cerebral glucose uptake. Findings: In this Data Note, we describe an open access dataset, Monash DaCRA fPET-fMRI, which contrasts three radiotracer administration protocols for FDG-fPET: bolus, constant infusion, and hybrid bolus/infusion. Participants (n=5 in each group) were randomly assigned to each radiotracer administration protocol and underwent simultaneous BOLD-fMRI/FDG-fPET scanning while viewing a flickering checkerboard. The Bolus group received the full FDG dose in a standard bolus administration; the Infusion group received the full FDG dose as a slow infusion over the duration of the scan, and the Bolus-Infusion group received 50% of the FDG dose as bolus and 50% as constant infusion. We validate the dataset by contrasting plasma radioactivity, grey matter mean uptake, and task-related activity in the visual cortex. Conclusions: The Monash DaCRA fPET-fMRI dataset provides significant re-use value for researchers interested in the comparison of signal dynamics in fPET, and its relationship with fMRI task-evoked activity.

Unsteady-State Coreflooding Monitored by Positron Emission Tomography and X-ray Computed Tomography

SPE Journal ◽  
2019 ◽  
Vol 25 (01) ◽  
pp. 242-252
Author(s):  
Yibing Hu ◽  
Ryan T. Armstrong ◽  
Igor Shikhov ◽  
Tzong T. Hung ◽  
Brendan Lee ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Temporal Resolution ◽  
Complex Function ◽  
Emission Tomography ◽  
Rock Properties ◽  
High Temporal Resolution ◽  
Porous Space ◽  
Micro Ct ◽  
Fluid Saturation ◽  
Positron Emission

Summary The forced-imbibition displacement process—a complex function of multiple physical properties of rock, fluids, and flow conditions—is of vital importance. For this paper we used imaging techniques to detect the process in three dimensions with high temporal resolution. Positron emission tomography (PET) is a powerful tool for imaging fluid transport in porous media because it has high temporal resolution and is not affected by complex lithology and pore structures. In this study, we conducted a detailed experimental and numerical analysis to prove how PET can be used with microcomputed tomography (micro-CT) to complement the imaging of water displacement in the porous space of sandstone. To characterize the rock properties, a dry sample was imaged with a high-resolution micro-CT scanner. The image was reconstructed and segmented into two phases (solid and void) to calculate the porosity/permeability relationship on cubic subsets. The Navier-Stokes equation was solved for permeability calculation. The porosity/permeability relationship was used as the input to simulate the forced imbibition process on an upscaled micro-CT image using the Matlab Reservoir Simulation Toolbox (MRST) (Lie et al. 2011; Krogstad et al. 2015; Lie 2016; Bao et al. 2017). The result was the evolution of invading-fluid saturation in every upscaled voxel. In the following step, water tracer labeled with fluorodeoxyglucose (18F-FDG) was injected into the dry sample and a series of PET images was acquired to detect fluid pathways. Fluid-front topology and a propagation procedure were captured. We integrated saturation data across the core cross section for both data sets (direct PET-based and MRST-simulated on upscaled tomograms) to reduce the complexity of the analysis. Comparison of the resulting 1D saturation profiles demonstrated the capability of PET imaging to monitor and understand dynamic flow processes in reservoir rocks.

Deciphering PDT-induced inflammatory responses using real-time FDG-PET in a mouse tumour model

2014 ◽  
Vol 13 (10) ◽  
pp. 1434-1443
Author(s):  
Nicole Cauchon ◽  
Haroutioun M. Hasséssian ◽  
Eric Turcotte ◽  
Roger Lecomte ◽  
Johan E. van Lier
Keyword(s):  
Positron Emission Tomography ◽  
Real Time ◽  
Fdg Pet ◽  
Inflammatory Responses ◽  
Metabolic Changes ◽  
Emission Tomography ◽  
Constant Infusion ◽  
Positron Emission ◽  
Mouse Tumour

Dynamic positron emission tomography (PET), combined with constant infusion of 2-deoxy-2-[18F]fluoro-d-glucose (FDG), enables real-time monitoring of transient metabolic changesin vivo, which can serve to understand the underlying physiology.

scholarly journals [18F]fluoro-2-deoxy-d-glucose ([18F]FDG) positron emission tomography imaging of thymic carcinoid tumor presenting with recurrent Cushing’s syndrome

2005 ◽  
Vol 152 (4) ◽  
pp. 521-525 ◽  
Author(s):  
Athina Markou ◽  
Patrick Manning ◽  
Banu Kaya ◽  
Sam N Datta ◽  
Jamshed B Bomanji ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
High Resolution ◽  
Carcinoid Tumor ◽  
Fdg Pet ◽  
Pet Scan ◽  
Emission Tomography ◽  
Thymic Carcinoid ◽  
Acth Secretion ◽  
Positron Emission ◽  
Thymic Carcinoid Tumor

We report a case of a young woman with Cushing’s syndrome (CS), in whom although endocrine investigations and negative pituitary imaging were suggestive of ectopic ACTH secretion, the results of inferior petrosal sinus (IPS) sampling after coricotropin-releasing hormone (CRH) stimulation were suggestive of pituitary ACTH hypersecretion. 111In-labelled octreotide and high-resolution computer tomography (CT) revealed a lesion possibly responsible for the ACTH source in the thymus. Thymectomy confirmed concomitant ectopic CRH and probable ACTH production by a thymic neuroendocrine carcinoma. After an 8-year remission period the patient developed a clinical and biochemical relapse. A high-resolution computed tomography (CT) scan of the thorax showed a 2-cm nodule in the thymic bed, which was positive on a [18F]fluoro-2-deoxy-d-glucose ([18F]FDG) positron emission tomography (PET) scan. However, a repeated thymectomy did not result in remission. A repeat [18F]FDG PET study showed persistent disease in the thymic bed and also uptake in the adrenals. The patient underwent bilateral adrenalectomy, which resulted in clinical remission. A further [18F]FDG PET scan 8 months later showed no progression of the thymic tumor and confirmed complete excision of the adrenals. This is a rare case of concomitant CRH and ACTH secretion from a thymic carcinoid tumor; the case illustrates the usefulness of functional imaging with [18F]FDG PET in the diagnosis, management and follow-up of neuroendocrine tumors.

scholarly journals Positron Emission Tomography (PET) Imaging of Multiple Myeloma in a Post-Treatment Setting

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 230
Author(s):  
Giulia Ferrarazzo ◽  
Silvia Chiola ◽  
Selene Capitanio ◽  
Maria Isabella Donegani ◽  
Alberto Miceli ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Multiple Myeloma ◽  
Fdg Pet ◽  
Therapy Monitoring ◽  
Emission Tomography ◽  
Clinical Value ◽  
Pet Tracers ◽  
Interpretation Criteria ◽  
Monitoring Therapy ◽  
Positron Emission

2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (FDG PET/CT) has an established clinical value in the diagnosis and initial staging of multiple myeloma (MM). In the last ten years, a vast body of literature has shown that this tool can also be of high relevance for monitoring therapy responses, making it the recommended imaging approach in this field. Starting from the strengths and weaknesses of radiological imaging in MM, the present review aims to analyze FDG PET/CT’s current clinical value focusing on therapy response assessment and objective interpretation criteria for therapy monitoring. Given the potential occurrence of patients with MM showing non-FDG-avid bone disease, new opportunities can be provided by non-FDG PET tracers. Accordingly, the potential role of non-FDG PET tracers in this setting has also been discussed.

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