scholarly journals 64-Channel Carbon Fiber Electrode Arrays for Chronic Electrophysiology

2019 ◽  
Author(s):  
Grigori Guitchounts ◽  
David Cox
Keyword(s):  
Carbon Fiber ◽  
Neuronal Activity ◽  
Electrode Array ◽  
Brain Regions ◽  
Electrode Arrays ◽  
Parylene C ◽  
Practical Tool ◽  
Freely Behaving ◽  
Carbon Fiber Electrode ◽  
Fiber Electrode

ABSTRACTA chief goal in neuroscience is to understand how neuronal activity relates to behavior, perception, and cognition. However, monitoring neuronal activity over long periods of time is technically challenging, and limited, in part, by the invasive nature of recording tools. While electrodes allow for recording in freely-behaving animals, they tend to be bulky and stiff, causing damage to the tissue they are implanted in. One solution to this invasiveness problem may be probes that are small enough to fly under the immune system’s radar. Carbon fiber (CF) electrodes are thinner and more flexible than typical metal or silicon electrodes, but the arrays described in previous reports had low channel counts and required time-consuming manual assembly. Here we report the design of an expanded-channel-count carbon fiber electrode array (CFEA) as well as a method for fast preparation of the recording sites using acid etching and electroplating with PEDOT-TFB, and demonstrate the ability of the 64-channel CFEA to record from rat visual cortex. We include designs for interfacing the system with micro-drives or flex-PCB cables for recording from multiple brain regions, as well as a facilitated method for coating CFs with the insulator Parylene-C. High-channel-count CFEAs may thus be an alternative to traditional microwire-based electrodes and a practical tool for exploring the neural code.

scholarly journals Benchtop Carbon Fiber Microelectrode Array Fabrication Toolkit

2021 ◽  
Author(s):  
Julianna M. Richie ◽  
Paras R. Patel ◽  
Elissa J. Welle ◽  
Tianshu Dong ◽  
Lei Chen ◽  
...  
Keyword(s):  
Carbon Fiber ◽  
Printed Circuit Boards ◽  
Electrode Array ◽  
Fabrication Process ◽  
Uv Laser ◽  
Electrode Arrays ◽  
Carbon Fiber Microelectrode ◽  
Carbon Fiber Electrode ◽  
Array Fabrication ◽  
Fiber Electrode

AbstractBackgroundConventional neural probes are primarily fabricated in a cleanroom, requiring the use of multiple expensive and highly specialized tools.New methodWe propose a cleanroom “light” fabrication process of carbon fiber neural electrode arrays that can be learned quickly by an inexperienced cleanroom user. This carbon fiber electrode array fabrication process requires just one cleanroom tool, a parylene-c deposition machine, that can be learned quickly or outsourced to a commercial processing facility at marginal cost. Our fabrication process also includes hand-populating printed circuit boards, insulation, and tip optimization.ResultsThe three different tip optimizations explored here (Nd:YAG laser, blowtorch, and UV laser) result in a range of tip geometries and 1kHz impedances, with blowtorched fibers resulting in the lowest impedance. While previous experiments have proven laser and blowtorch electrode efficacy, this paper also shows UV laser cut fibers can record neural signals in vivo.Comparison with existing methodsExisting carbon fiber arrays either do not have individuated electrodes in favor of bundles or require cleanroom fabricated guides for population and insulation. The proposed arrays use only tools that can be used at a benchtop for fiber population.ConclusionsThis carbon fiber electrode array fabrication process allows for quick customization of bulk array fabrication at a reduced price compared to commercially available probes.

scholarly journals A carbon-fiber electrode array for long-term neural recording

2013 ◽  
Vol 10 (4) ◽  
pp. 046016 ◽  
Author(s):  
Grigori Guitchounts ◽  
Jeffrey E Markowitz ◽  
William A Liberti ◽  
Timothy J Gardner
Keyword(s):  
Carbon Fiber ◽  
Electrode Array ◽  
Neural Recording ◽  
Carbon Fiber Electrode ◽  
Fiber Electrode

scholarly journals Sharpened and mechanically durable carbon fiber electrode arrays for neural recording

2021 ◽  
pp. 1-1
Author(s):  
Elissa J. Welle ◽  
Joshua E. Woods ◽  
Ahmad A. Jiman ◽  
Julianna M. Richie ◽  
Elizabeth C. Bottorff ◽  
...  
Keyword(s):  
Carbon Fiber ◽  
Neural Recording ◽  
Electrode Arrays ◽  
Carbon Fiber Electrode ◽  
Fiber Electrode

scholarly journals Insertion of linear 8.4μm diameter 16 channel carbon fiber electrode arrays for single unit recordings

2015 ◽  
Vol 12 (4) ◽  
pp. 046009 ◽  
Author(s):  
Paras R Patel ◽  
Kyounghwan Na ◽  
Huanan Zhang ◽  
Takashi D Y Kozai ◽  
Nicholas A Kotov ◽  
...  
Keyword(s):  
Carbon Fiber ◽  
Single Unit ◽  
Electrode Arrays ◽  
Single Unit Recordings ◽  
Carbon Fiber Electrode ◽  
Fiber Electrode

scholarly journals High-Resolution Three-Dimensional Extracellular Recording of Neuronal Activity With Microfabricated Electrode Arrays

2009 ◽  
Vol 101 (3) ◽  
pp. 1671-1678 ◽  
Author(s):  
Jiangang Du ◽  
Ingmar H. Riedel-Kruse ◽  
Janna C. Nawroth ◽  
Michael L. Roukes ◽  
Gilles Laurent ◽  
...  
Keyword(s):  
Neuronal Activity ◽  
Large Scale ◽  
Microelectrode Array ◽  
3D Structure ◽  
Three Dimensional ◽  
Electrode Array ◽  
Extracellular Recording ◽  
Brain Regions ◽  
Electrode Arrays ◽  
The Brain

Microelectrode array recordings of neuronal activity present significant opportunities for studying the brain with single-cell and spike-time precision. However, challenges in device manufacturing constrain dense multisite recordings to two spatial dimensions, whereas access to the three-dimensional (3D) structure of many brain regions appears to remain a challenge. To overcome this limitation, we present two novel recording modalities of silicon-based devices aimed at establishing 3D functionality. First, we fabricated a dual-side electrode array by patterning recording sites on both the front and back of an implantable microstructure. We found that the majority of single-unit spikes could not be simultaneously detected from both sides, suggesting that in addition to providing higher spatial resolution measurements than that of single-side devices, dual-side arrays also lead to increased recording yield. Second, we obtained recordings along three principal directions with a multilayer array and demonstrated 3D spike source localization within the enclosed measurement space. The large-scale integration of such dual-side and multilayer arrays is expected to provide massively parallel recording capabilities in the brain.

Synergistic effect of LiF coating and carbon fiber electrode on enhanced electrochemical performance of Li2MnSiO4

2021 ◽  
Vol 373 ◽  
pp. 137911
Author(s):  
S. Krishna Kumar ◽  
Sourav Ghosh ◽  
Madhushri Bhar ◽  
Ajay K. Kavala ◽  
Sivaraman Patchaiyappan ◽  
...  
Keyword(s):  
Carbon Fiber ◽  
Synergistic Effect ◽  
Electrochemical Performance ◽  
Carbon Fiber Electrode ◽  
Enhanced Electrochemical Performance ◽  
Fiber Electrode

Electrochemical sensor for nitric oxide using layered films composed of a polycationic dendrimer and nickel(II) phthalocyaninetetrasulfonate deposited on a carbon fiber electrode

2014 ◽  
Vol 182 (5-6) ◽  
pp. 1079-1087 ◽  
Author(s):  
Juliana Cancino ◽  
Sabine Borgmann ◽  
Sergio A. S. Machado ◽  
Valtencir Zucolotto ◽  
Wolfgang Schuhmann ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Fiber ◽  
Electrochemical Sensor ◽  
Carbon Fiber Electrode ◽  
Fiber Electrode
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