scholarly journals Establishing and Interpreting Graded Sonic Hedgehog Signaling during Vertebrate Neural Tube Patterning: The Role of Negative Feedback

2009 ◽  
Vol 1 (2) ◽  
pp. a002014-a002014 ◽  
Author(s):  
V. Ribes ◽  
J. Briscoe
Keyword(s):  
Sonic Hedgehog ◽  
Neural Tube ◽  
Negative Feedback ◽  
Hedgehog Signaling ◽  
Sonic Hedgehog Signaling

scholarly journals A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance

Blood ◽  
2014 ◽  
Vol 124 (13) ◽  
pp. 2061-2071 ◽  
Author(s):  
Zhiqiang Liu ◽  
Jingda Xu ◽  
Jin He ◽  
Yuhuan Zheng ◽  
Haiyan Li ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cell Survival ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Critical Role ◽  
Myeloma Cell ◽  
Sonic Hedgehog Signaling ◽  
Key Points

Key Points CD138+ MM cells are a major source of SHH. Autocrine SHH enhances MM drug resistance.

Role of Sonic Hedgehog Signaling in Oligodendrocyte Differentiation

2016 ◽  
Vol 41 (12) ◽  
pp. 3289-3299 ◽  
Author(s):  
Li-Chun Wang ◽  
Guillermina Almazan
Keyword(s):  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Oligodendrocyte Differentiation ◽  
Sonic Hedgehog Signaling

The role of Sonic hedgehog signaling in the developing cerebral cortex

2007 ◽  
Vol 58 ◽  
pp. S82
Author(s):  
Munekazu Komada ◽  
Hirotomo Saitsu ◽  
Kohei Shiota ◽  
Makoto Ishibashi
Keyword(s):  
Cerebral Cortex ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Sonic Hedgehog Signaling

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

Development ◽  
1998 ◽  
Vol 125 (14) ◽  
pp. 2533-2543 ◽  
Author(s):  
Q. Ding ◽  
J. Motoyama ◽  
S. Gasca ◽  
R. Mo ◽  
H. Sasaki ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Motor Neurons ◽  
Neural Tube ◽  
Hedgehog Signaling ◽  
Zinc Finger Protein ◽  
Floor Plate ◽  
Mutant Mice ◽  
Sonic Hedgehog Signaling ◽  
Cubitus Interruptus ◽  
High Level

Floor plate cells at the midline of the neural tube are specified by high-level activity of Sonic hedgehog (Shh) secreted by notochord, whereas motor neurons are thought to be specified by a lower level activity of Shh secreted in turn by floor plate cells. In Drosophila, the Gli zinc finger protein Cubitus interruptus functions as a transcription factor activating Hedgehog-responsive genes. We report that the expression of known Shh-responsive genes such as Ptc and Gli1 is downregulated in mutant mice lacking Gli2 function. Gli2 mutants fail to develop a floor plate yet still develop motor neurons, which occupy the ventral midline of the neural tube. Our results imply that Gli2 is required to mediate high level but not low level Shh activity and show that the development of motor neurons can occur in the absence of floor plate induction.

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