scholarly journals Hepatitis D Virus Replication

2015 ◽  
Vol 5 (11) ◽  
pp. a021568 ◽  
Author(s):  
John M. Taylor
Keyword(s):  
Virus Replication ◽  
Hepatitis D ◽  
Hepatitis D Virus

Hepatitis B virus replication modulates pathogenesis of hepatitis D virus in chronic hepatitis D

Hepatology ◽  
1991 ◽  
Vol 13 (3) ◽  
pp. 413-416 ◽  
Author(s):  
Antonina Smedile ◽  
Floriano Rosina ◽  
Giorgio Saracco ◽  
Elisabetta Chiaberge ◽  
Valter Lattore ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Hepatitis D ◽  
Hepatitis D Virus ◽  
B Virus

scholarly journals Identification of the Functional Regions Required for Hepatitis D Virus Replication and Transcription by Linker-Scanning Mutagenesis of Viral Genome

Virology ◽  
1997 ◽  
Vol 239 (1) ◽  
pp. 119-131 ◽  
Author(s):  
Hsei-Wei Wang ◽  
Hui-Lin Wu ◽  
Ding-Shinn Chen ◽  
Pei-Jer Chen
Keyword(s):  
Virus Replication ◽  
Viral Genome ◽  
Hepatitis D ◽  
Hepatitis D Virus ◽  
Functional Regions

Hepatitis B virus and hepatitis D virus replication in HBsAg-positive fulminant hepatitis

Hepatology ◽  
1990 ◽  
Vol 11 (6) ◽  
pp. 1062-1065 ◽  
Author(s):  
Antoni Mas ◽  
María Buti ◽  
Rafael Esteban ◽  
José M. Sánchez-Tapias ◽  
Josep Costa ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Fulminant Hepatitis ◽  
Hepatitis D ◽  
Hepatitis D Virus ◽  
B Virus

scholarly journals Effect of Tenofovir With and Without Interferon on Hepatitis D Virus Replication in HIV–Hepatitis B Virus–Hepatitis D Virus-Infected Patients

2013 ◽  
Vol 29 (12) ◽  
pp. 1535-1540 ◽  
Author(s):  
Anders Boyd ◽  
Patrick Miailhes ◽  
Ségolène Brichler ◽  
Caroline Scholtès ◽  
Sarah Maylin ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Virus Hepatitis ◽  
Hepatitis D ◽  
Hepatitis D Virus ◽  
B Virus

Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes

2018 ◽  
Vol 69 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Zhenfeng Zhang ◽  
Christina Filzmayer ◽  
Yi Ni ◽  
Holger Sültmann ◽  
Pascal Mutz ◽  
...  
Keyword(s):  
Virus Replication ◽  
Hepatitis D ◽  
Hepatitis D Virus

scholarly journals Hepatitis D virus in 2021: virology, immunology and new treatment approaches for a difficult-to-treat disease

Gut ◽  
2021 ◽  
pp. gutjnl-2020-323888
Author(s):  
Stephan Urban ◽  
Christoph Neumann-Haefelin ◽  
Pietro Lampertico
Keyword(s):  
Hepatitis B ◽  
Hepatitis B Surface Antigen ◽  
Treatment Strategies ◽  
Phase Iii ◽  
Interferon Α ◽  
T Cell Epitopes ◽  
The European Union ◽  
Hepatitis D ◽  
Hepatitis D Virus

Approximately 5% of individuals infected with hepatitis B virus (HBV) are coinfected with hepatitis D virus (HDV). Chronic HBV/HDV coinfection is associated with an unfavourable outcome, with many patients developing liver cirrhosis, liver failure and eventually hepatocellular carcinoma within 5–10 years. The identification of the HBV/HDV receptor and the development of novel in vitro and animal infection models allowed a more detailed study of the HDV life cycle in recent years, facilitating the development of specific antiviral drugs. The characterisation of HDV-specific CD4+ and CD8+T cell epitopes in untreated and treated patients also permitted a more precise understanding of HDV immunobiology and possibly paves the way for immunotherapeutic strategies to support upcoming specific therapies targeting viral or host factors. Pegylated interferon-α has been used for treating HDV patients for the last 30 years with only limited sustained responses. Here we describe novel treatment options with regard to their mode of action and their clinical effectiveness. Of those, the entry-inhibitor bulevirtide (formerly known as myrcludex B) received conditional marketing authorisation in the European Union (EU) in 2020 (Hepcludex). One additional drug, the prenylation inhibitor lonafarnib, is currently under investigation in phase III clinical trials. Other treatment strategies aim at targeting hepatitis B surface antigen, including the nucleic acid polymer REP2139Ca. These recent advances in HDV virology, immunology and treatment are important steps to make HDV a less difficult-to-treat virus and will be discussed.

Chronic Hepatitis D Virus (HDV) Infection in Hepatitis B Virus Carrier Chimpanzees Experimentally Superinfected with HDV

1988 ◽  
Vol 158 (1) ◽  
pp. 151-159 ◽  
Author(s):  
F. Negro ◽  
K. F. Bergmann ◽  
B. M. Baroudy ◽  
W. C. Satterfield ◽  
H. Popper ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatitis D ◽  
Hepatitis D Virus ◽  
B Virus ◽  
Hepatitis B Virus Carrier ◽  
Hdv Infection ◽  
Virus Carrier
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