In this paper, we study the recent 750 GeV diphoton excess in the Hill model with vector-like fermions. The singlet-like Hill boson is chosen as the 750 GeV diphoton resonance. Such a scalar is mainly produced by gluon fusion via vector-like top and bottom quark loops and decays to diphoton via the vector-like quark and lepton loops. Under the current experimental and theoretical constraints, we find that the mixing angle of the singlet and doublet Higgs bosons lies within [Formula: see text] and the 750 GeV diphoton cross-section can be maximally enhanced to about 6 fb at 13 TeV LHC. Moreover, we find that the Hill boson pair production in [Formula: see text] channel can be probed at [Formula: see text] significance if [Formula: see text] and [Formula: see text] at a 100 TeV collider with 3000 fb[Formula: see text] luminosity.