scholarly journals Consistency of Planck, ACT, and SPT constraints on magnetically assisted recombination and forecasts for future experiments

2022 ◽  
Vol 105 (2) ◽  
Author(s):  
Silvia Galli ◽  
Levon Pogosian ◽  
Karsten Jedamzik ◽  
Lennart Balkenhol
2020 ◽  
Author(s):  
R. Kevin Tindell ◽  
Lincoln Busselle ◽  
Julianne Holloway

<div>Musculoskeletal interfacial tissues consist of complex gradients in structure, cell phenotype, and biochemical signaling that are important for function. Designing tissue engineering strategies to mimic these types of gradients is an ongoing challenge. In particular, new fabrication techniques that enable precise spatial control over fiber alignment are needed to better mimic the structural gradients present in interfacial tissues, such as the tendon-bone interface. Here, we report a modular approach to spatially controlling fiber alignment using magnetically-assisted electrospinning. Electrospun fibers were highly aligned in the presence of a magnetic field and smoothly transitioned to randomly aligned fibers away from the magnetic field. Importantly, magnetically-assisted electrospinning allows for spatial control over fiber alignment at sub-millimeter resolution along the length of the fibrous scaffold similar to the native structural gradient present in many interfacial tissues. The versatility of this approach was further demonstrated using multiple electrospinning polymers and different magnet configurations to fabricate complex fiber alignment gradients. As expected, cells seeded onto gradient fibrous scaffolds were elongated and aligned on the aligned fibers and did not show a preferential alignment on the randomly aligned fibers. Overall, this fabrication approach represents an important step forward in creating gradient fibrous materials and are promising as tissue-engineered scaffolds for regenerating functional musculoskeletal interfacial tissues. <br></div>


2020 ◽  
Author(s):  
R. Kevin Tindell ◽  
Lincoln Busselle ◽  
Julianne Holloway

<div>Musculoskeletal interfacial tissues consist of complex gradients in structure, cell phenotype, and biochemical signaling that are important for function. Designing tissue engineering strategies to mimic these types of gradients is an ongoing challenge. In particular, new fabrication techniques that enable precise spatial control over fiber alignment are needed to better mimic the structural gradients present in interfacial tissues, such as the tendon-bone interface. Here, we report a modular approach to spatially controlling fiber alignment using magnetically-assisted electrospinning. Electrospun fibers were highly aligned in the presence of a magnetic field and smoothly transitioned to randomly aligned fibers away from the magnetic field. Importantly, magnetically-assisted electrospinning allows for spatial control over fiber alignment at sub-millimeter resolution along the length of the fibrous scaffold similar to the native structural gradient present in many interfacial tissues. The versatility of this approach was further demonstrated using multiple electrospinning polymers and different magnet configurations to fabricate complex fiber alignment gradients. As expected, cells seeded onto gradient fibrous scaffolds were elongated and aligned on the aligned fibers and did not show a preferential alignment on the randomly aligned fibers. Overall, this fabrication approach represents an important step forward in creating gradient fibrous materials and are promising as tissue-engineered scaffolds for regenerating functional musculoskeletal interfacial tissues. <br></div>


2021 ◽  
Vol 93 (6) ◽  
pp. AB200
Author(s):  
Yun Jeong Lim ◽  
Ji Hyung Nam ◽  
Dong Jun Oh ◽  
Kwang Seop Kim ◽  
Junseok Park ◽  
...  

Endoscopy ◽  
2018 ◽  
Vol 51 (05) ◽  
pp. 409-418 ◽  
Author(s):  
Hey-Long Ching ◽  
Melissa F. Hale ◽  
Matthew Kurien ◽  
Jennifer A. Campbell ◽  
Stefania Chetcuti Zammit ◽  
...  

Abstract Background Small-bowel capsule endoscopy is advocated and repeat upper gastrointestinal (GI) endoscopy should be considered for evaluation of recurrent or refractory iron deficiency anemia (IDA). A new device that allows magnetic steering of the capsule around the stomach (magnetically assisted capsule endoscopy [MACE]), followed by passive small-bowel examination might satisfy both requirements in a single procedure. Methods In this prospective cohort study, MACE and esophagogastroduodenoscopy (EGD) were performed in patients with recurrent or refractory IDA. Comparisons of total (upper GI and small bowel) and upper GI diagnostic yields, gastric mucosal visibility, and patient comfort scores were the primary end points. Results 49 patients were recruited (median age 64 years; 39 % male). Combined upper and small-bowel examination using the new capsule yielded more pathology than EGD alone (113 vs. 52; P < 0.001). In upper GI examination (proximal to the second part of the duodenum, D2), MACE identified more total lesions than EGD (88 vs. 52; P < 0.001). There was also a difference if only IDA-associated lesions (esophagitis, altered/fresh blood, angioectasia, ulcers, and villous atrophy) were included (20 vs. 10; P = 0.04). Pathology distal to D2 was identified in 17 patients (34.7 %). Median scores (0 – 10 for none – extreme) for pain (0 vs. 2), discomfort (0 vs. 3), and distress (0 vs. 4) were lower for MACE than for EGD (P < 0.001). Conclusion Combined examination of the upper GI tract and small bowel using the MACE capsule detected more pathology than EGD alone in patients with recurrent or refractory IDA. MACE also had a higher diagnostic yield than EGD in the upper GI tract and was better tolerated by patients.


2021 ◽  
Vol 11 (6) ◽  
pp. 176-187
Author(s):  
Mahammed Athar Alli Saikh ◽  
Prithwiraj Mohapatra

The manuscript aims to provide glimpse on updated information relating thermo-mechanical dry coating processes (TMDCP) suiting in modifying surface attributes of fine and ultra-fine particle (FiUlFiP). FiUlFiPs are the integral component of pharmaceutical processes. They exhibit complex and queer properties, are conferred mostly from their surface attributes colligated with their higher surface area. Particle engineering technocrats extensively working for modifying surface & surface attributes of FiUlFiPs. These efforts are to find their worthy applications & new functionalities. Among available diverse particle engineering technologies/ process, TMDCP, a dry coating process (DCP), advocated being worthy and efficient. The TMDCP finds multidisciplinary applications, mostly in drug development & drug delivery. Said DCP involves fixing and/or attaching coating material (CoM) as particles herein synonym guest particle (GP) onto core/substrate particle (CSP) herein synonym host particle (HP). Attaching/ fixing the GPs onto HPs, in TMDCP, involve their mechanical and/or thermal interactions. Scientific literatures are evidencing diverse techniques and/or process, basing on discussed interactions. Amongst them novel techniques/ processes are Hybridization, Magnetically assisted impaction coating process (MAICP), Mechanofusion, Theta-composer, and high shear compaction. In this area diverse devices/ equipments are prevailing in market. Important are Hybridizer, Magnetically assisted impaction coater (MAIC), Theta-composer, Mechanofusion, Quadro Comil®, Cyclomix®, and many others. Attempt of this article is to discuss and present their method of working, working principle, applicability, limitations, and benefits. Contained information might be beneficial for professionals of pharmaceutical and allied field. Keywords: dry coating, equipment, particles, processes, thermo-mechanical.


2016 ◽  
Vol 302 ◽  
pp. 560-569 ◽  
Author(s):  
Sofia F. Soares ◽  
Tânia R. Simões ◽  
Maria António ◽  
Tito Trindade ◽  
Ana L. Daniel-da-Silva

2006 ◽  
Vol 110 (40) ◽  
pp. 19929-19934 ◽  
Author(s):  
Hongmei Huang ◽  
Jeffrey N. Anker ◽  
Kemin Wang ◽  
Raoul Kopelman

Sign in / Sign up

Export Citation Format

Share Document