Integrative Study Reveals Sodium Dependence of a Barley Borate Transporter

Personalised and contextualised care has been turned into a major demand by people involved in healthcare suggesting to move toward person-centred medicine. The assessment of person-centred medicine can be most effectively achieved if treatments are investigated using ‘with versus without’ person-centredness or integrative study designs. However, this assumes that the components of an integrative or person-centred intervention have an additive relationship to produce the total effect. Beecher’s model of additivity assumes an additive relation between placebo and drug effects and is thus presenting an arithmetic summation. So far, no review has been carried out assessing the validity of the additive model, which is to be questioned and more closely investigated in this review. Initial searches for primary studies were undertaken in July 2016 using Pubmed and Google Scholar. In order to find matching publications of similar magnitude for the comparison part of this review, corresponding matches for all included reviews were sought. A total of 22 reviews and 3 clinical and experimental studies fulfilled the inclusion criteria. The results pointed to the following factors actively questioning the additive model: interactions of various effects, trial design, conditioning, context effects and factors, neurobiological factors, mechanism of action, statistical factors, intervention-specific factors (alcohol, caffeine), side-effects and type of intervention. All but one of the closely assessed publications was questioning the additive model. A closer examination of study design is necessary. An attempt in a more systematic approach geared towards solutions could be a suggestion for future research in this field.

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Integrative Study of Physiological Changes Associated with Bacterial Infection in Pacific Oyster Larvae

PLoS ONE ◽

10.1371/journal.pone.0064534 ◽

2013 ◽

Vol 8 (5) ◽

pp. e64534 ◽

Cited By ~ 64

Author(s):

Bertrand Genard ◽

Philippe Miner ◽

Jean-Louis Nicolas ◽

Dario Moraga ◽

Pierre Boudry ◽

...

Keyword(s):

Bacterial Infection ◽

Pacific Oyster ◽

Physiological Changes ◽

Integrative Study

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Growth and carbon balance are differently regulated by tree and shoot fruiting contexts: an integrative study on apple genotypes with contrasted bearing patterns

Tree Physiology ◽

10.1093/treephys/tpx166 ◽

2018 ◽

Vol 38 (9) ◽

pp. 1395-1408 ◽

Cited By ~ 6

Author(s):

Benoît Pallas ◽

Sylvie Bluy ◽

Jérôme Ngao ◽

Sébastien Martinez ◽

Anne Clément-Vidal ◽

...

Keyword(s):

Carbon Balance ◽

Integrative Study

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Towards a better understanding of the genus Sciurella Allman, 1883 (Cnidaria: Hydrozoa: Plumulariidae): evidence from an integrative study

Zootaxa ◽

10.11646/zootaxa.5040.1.1 ◽

2021 ◽

Vol 5040 (1) ◽

pp. 1-32

Author(s):

HORIA R. GALEA ◽

DAVIDE MAGGIONI ◽

CRISTINA G. DI CAMILLO

Keyword(s):

Genetic Data ◽

Nominal Species ◽

Reliable Evidence ◽

Molecular Studies ◽

Integrative Study ◽

Phylogenetic Hypotheses

The genus Sciurella Allman, 1883 is reassessed based on fertile specimens from Indonesia and Australia, using both morphological and genetic approaches. The genus is resurrected and kept distinct from Nemertesia Lamouroux, 1812 on the account of its long, tubular hydrothecae, and the gonothecae (of which only the female ones are known) provided with nematothecae. Stellate gonothecae correspond to S. indivisa Allman, 1883, while urn-shaped gonothecae are subjectively attributable to S. cylindrica (Kirchenpauer, 1876), comb. nov., a nominal species originally described based on sterile material. The taxonomy of the latter species is discussed in light of the available literature data, and Antennularia cylindrica Bale, 1884 is confidently assigned to its synonymy. Plumularia dolichotheca Allman, 1883 is provisionally transferred to Sciurella, as S. dolichotheca comb. nov., pending the discovery of fertile specimens and reliable evidence from molecular studies. The newly-generated genetic data for S. indivisa and S. cylindrica clearly confirm the distinction between Sciurella and Nemertesia, the two genera occupying divergent positions within the Plumulariidae phylogenetic hypotheses.

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