A fluorophore-labelled copper complex: crystal structure, hybrid cyclic water–perchlorate cluster and biological properties

A fluorophore-labelled copper(II) complex, aquabis(dimethylformamide-κO)(perchlorato-κO)[2-(quinolin-2-yl)-1,3-oxazolo[4,5-f][1,10]phenanthroline]copper(II) perchlorate monohydrate, [Cu(ClO4)(C22H12N4O)(C3H7NO)2(H2O)]ClO4·H2O, has been synthesized and characterized. A cyclic hydrogen-bonded water–perchlorate anionic cluster, i.e. [(ClO4)2(H2O)2]2−, has been identified within the structure. Each cyclic anionic cluster unit is interconnected by hydrogen bonding to the cation. The cations join into an infinite hydrogen-bonded chain running in the [010] direction. Furthermore, interaction of the complex with calf-thymus DNA (CT-DNA) and cellular localization within the cells was explored. Spectroscopic studies indicate that the compound has a good affinity for DNA and stains the nucleus of the cells.

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Calorimetric and Spectroscopic Studies to Monitor the Interaction of L-Cysteine Functionalized Selenium Nanoparticles with Calf Thymus DNA

Advanced Science Letters ◽

10.1166/asl.2018.12163 ◽

2018 ◽

Vol 24 (8) ◽

pp. 5624-5628 ◽

Cited By ~ 4

Author(s):

Riju K Thomas ◽

S Prasanth ◽

T. V Vineeshkumar ◽

C Sudarsanakumar

Keyword(s):

Binding Sites ◽

Binding Constant ◽

Spectrophotometric Titration ◽

Spectroscopic Studies ◽

Binding Energies ◽

Selenium Nanoparticles ◽

Calf Thymus Dna ◽

Calf Thymus ◽

Number Of Binding Sites ◽

Ct Dna

The focus of the study is to understand the interaction between calf thymus DNA and L-Cysteine capped Selenium nanoparticles (cys-SeNPs) using spectroscopic and calorimetric techniques. The size of the nanoparticles was confirmed using transmission electron microscope (TEM). Isothermal titration calorimerty (ITC) provided the binding energy, the number of binding sites and the thermodynamic parameters. UV-Vis absorption and fluorescence quenching studies established the number of binding sites and binding constant. Stabilization of the ct-DNA in the presence of cys-SeNPs was determined from thermal melting studies. It is confirmed by the spectrophotometric titration and calorimetric studies that, selenium nanoparticles can form a complex with the double–helical DNA. The binding constant of cys-SeNPs with the DNA from fluorescence study was found to be 2.953 × 106 M−1 and is consistent with the value obtained from ITC experiment. The binding energies along with the binding sites symbolize the crucial role of van der Waals forces and hydrogen bonds in the binding of cys-SeNPs with ct-DNA.

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DNA Binding and Photocleavage Studies of Cobalt(III) Polypyridine Complexes: [Co(en)2PIP]3+, [Co(en)2IP]3+, and [Co(en)2phen-dione]3+

Bioinorganic Chemistry and Applications ◽

10.1155/2007/54562 ◽

2007 ◽

Vol 2007 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Penumaka Nagababu ◽

S. Satyanarayana

Keyword(s):

Plasmid Dna ◽

Emission Spectroscopy ◽

Spectroscopic Studies ◽

Calf Thymus Dna ◽

Dna Melting ◽

Base Pairs ◽

Viscosity Measurements ◽

Calf Thymus ◽

Polypyridine Complexes ◽

Ct Dna

In this paper, three complexes of type[Co(en)2PIP]3+(PIP=2-phenylimidazo[4,5-f][1,10,] phenanthroline)(1),[Co(en)2IP]3+(IP=imidazo[4,5-f][1,10,] phenanthroline)(2), and[Co(en)2phen-dione]3+(1,10 phenanthroline 5,6,dione)(3) have been synthesized and characterized by UV/VIS, IR,1HNMR spectral methods. Absorption spectroscopy, emission spectroscopy, viscosity measurements, and DNA melting techniques have been used for investigating the binding of these two complexes with calf thymus DNA, and photocleavage studies were used for investigating these binding of these complexes with plasmid DNA. The spectroscopic studies together with viscosity measurements and DNA melting studies support that complexes 1 and 2 bind to CT DNA(=calf thymus DNA) by intercalation mode via IP or PIP into the base pairs of DNA, and complex 3 is binding as groove mode. Complex 1 binds more avidly to CT DNA than 2 and 3 which is consistent with the extended planar ringπsystem of PIP. Noticeably, the two complexes have been found to be efficient photosensitisers for strand scissions in plasmid DNA.

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A Purely Organic Molecular Metal Based on a Hydrogen-Bonded Charge-Transfer Complex: Crystal Structure and Electronic Properties of TTF-Imidazole-p-Chloranil

Angewandte Chemie ◽

10.1002/ange.200460801 ◽

2004 ◽

Vol 116 (46) ◽

pp. 6503-6506 ◽

Cited By ~ 14

Author(s):

Tsuyoshi Murata ◽

Yasushi Morita ◽

Kozo Fukui ◽

Kazunobu Sato ◽

Daisuke Shiomi ◽

...

Keyword(s):

Crystal Structure ◽

Charge Transfer ◽

Electronic Properties ◽

Charge Transfer Complex ◽

Complex Crystal Structure ◽

Complex Crystal ◽

Hydrogen Bonded

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Surfactant Complex Binding to DNA Interaction Study: Controlling Hydrophobicity in β-Cyclodextrin–DNA Binding Reactions

International Journal of Agricultural and Life sciences ◽

10.22573/spg.ijals.020.s122000102 ◽

2020 ◽

pp. 318-332

Author(s):

Nagaraj Karuppiah ◽

◽

Muthukumaran Pakkirisamy ◽

Gunasekaran Gladwin ◽

Keyword(s):

Dna Interaction ◽

Spectroscopic Studies ◽

Calf Thymus Dna ◽

Aliphatic Chain ◽

Groove Binding ◽

Base Pairs ◽

Surfactant Complex ◽

Calf Thymus ◽

Frame Work ◽

Ct Dna

The interaction of cis-[Co(phen)2(TA)2](ClO4)3, a cationic surfactant complex (phen = 1-10 phenanthroline, TA= Tetradecylamine), with calf thymus DNA has been studied by physici-chemical techniques. The spectroscopic studies together with cyclic voltammetry and viscosity experiments support that the surfactant-cobalt(III) complex binds to calf thymus DNA (CT DNA) by intercalation through the aliphatic chain present in the complex into the base pairs of DNA. The presence of phenanthroline ligand with larger -frame work may also enhance intercalation. Besides the effect of binding of surfactant cobalt(III) complex to DNA in presence of -cyclodextrin has also studied. In presence of -cyclodextrin the binding occur through surface and (or) groove binding. The complex was investigated as one of the potential

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