scholarly journals 3D Deep Learning for Biological Function Prediction from Physical Fields

Author(s):  
Vladimir Golkov ◽  
Marcin J. Skwark ◽  
Atanas Mirchev ◽  
Georgi Dikov ◽  
Alexander R. Geanes ◽  
...  
2021 ◽  
Author(s):  
Xian Tan ◽  
Minghang Zou ◽  
Di Wu ◽  
Jingbo Zhang ◽  
Pingping Sun ◽  
...  

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Chin-Chi Kuo ◽  
Chun-Min Chang ◽  
Kuan-Ting Liu ◽  
Wei-Kai Lin ◽  
Hsiu-Yin Chiang ◽  
...  

2020 ◽  
Vol 118 (3) ◽  
pp. 533a
Author(s):  
Safyan Aman Memon ◽  
Kinaan Aamir Khan ◽  
Hammad Naveed

2020 ◽  
Vol 10 (14) ◽  
pp. 4999
Author(s):  
Dongbo Shi ◽  
Lei Sun ◽  
Yonghui Xie

The reliable design of the supercritical carbon dioxide (S-CO2) turbine is the core of the advanced S-CO2 power generation technology. However, the traditional computational fluid dynamics (CFD) method is usually applied in the S-CO2 turbine design-optimization, which is a high computational cost, high memory requirement, and long time-consuming solver. In this research, a flexible end-to-end deep learning approach is presented for the off-design performance prediction of the S-CO2 turbine based on physical fields reconstruction. Our approach consists of three steps: firstly, an optimal design of a 60,000 rpm S-CO2 turbine is established. Secondly, five design variables for off-design analysis are selected to reconstruct the temperature and pressure fields on the blade surface through a deconvolutional neural network. Finally, the power and efficiency of the turbine is predicted by a convolutional neural network according to reconstruction fields. The results show that the prediction approach not only outperforms five classical machine learning models but also focused on the physical mechanism of turbine design. In addition, once the deep model is well-trained, the calculation with graphics processing unit (GPU)-accelerated can quickly predict the physical fields and performance. This prediction approach requires less human intervention and has the advantages of being universal, flexible, and easy to implement.


2021 ◽  
Author(s):  
Sungwoo Bae ◽  
Hongyoon Choi ◽  
Dong Soo Lee

Abstract Profiling molecular features associated with the morphological landscape of tissue is crucial for investigating the structural and spatial patterns that underlie the biological function of tissues. In this study, we present a new method, spatial gene expression patterns by deep learning of tissue images (SPADE), to identify important genes associated with morphological contexts by combining spatial transcriptomic data with coregistered images. SPADE incorporates deep learning-derived image patterns with spatially resolved gene expression data to extract morphological context markers. Morphological features that correspond to spatial maps of the transcriptome were extracted by image patches surrounding each spot and were subsequently represented by image latent features. The molecular profiles correlated with the image latent features were identified. The extracted genes could be further analyzed to discover functional terms and exploited to extract clusters maintaining morphological contexts. We apply our approach to spatial transcriptomic data from different tissues, platforms and types of images to demonstrate an unbiased method that is capable of obtaining image-integrated gene expression trends.


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