Contrast-enhanced Thermoacoustic Imaging for Breast Tumor Detection with Sparse Measurements

Author(s):  
Baosheng Wang ◽  
Lifan Xu ◽  
Xiong Wang
Nanoscale ◽  
2020 ◽  
Vol 12 (30) ◽  
pp. 16034-16040
Author(s):  
Le Zhang ◽  
Huan Qin ◽  
Fanchu Zeng ◽  
Zhujun Wu ◽  
Linghua Wu ◽  
...  

Microwave-induced thermoacoustic imaging (MTAI), combining the advantages of the high contrast of microwave imaging and the high resolution of ultrasonic imaging, is a potential candidate for breast tumor detection.


2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii93-ii93
Author(s):  
Kate Connor ◽  
Emer Conroy ◽  
Kieron White ◽  
Liam Shiels ◽  
William Gallagher ◽  
...  

Abstract Despite magnetic resonance imaging (MRI) being the gold-standard imaging modality in the glioblastoma (GBM) setting, the availability of rodent MRI scanners is relatively limited. CT is a clinically relevant alternative which is more widely available in the pre-clinic. To study the utility of contrast-enhanced (CE)-CT in GBM xenograft modelling, we optimized CT protocols on two instruments (IVIS-SPECTRUM-CT;TRIUMPH-PET/CT) with/without delivery of contrast. As radiomics analysis may facilitate earlier detection of tumors by CT alone, allowing for deeper analyses of tumor characteristics, we established a radiomic pipeline for extraction and selection of tumor specific CT-derived radiomic features (inc. first order statistics/texture features). U87R-Luc2 GBM cells were implanted orthotopically into NOD/SCID mice (n=25) and tumor growth monitored via weekly BLI. Concurrently mice underwent four rounds of CE-CT (IV iomeprol/iopamidol; 50kV-scan). N=45 CE-CT images were semi-automatically delineated and radiomic features were extracted (Pyradiomics 2.2.0) at each imaging timepoint. Differences between normal and tumor tissue were analyzed using recursive selection. Using either CT instrument/contrast, tumors > 0.4cm3 were not detectable until week-9 post-implantation. Radiomic analysis identified three features (waveletHHH_firstorder_Median, original_glcm_Correlation and waveletLHL_firstorder_Median) at week-3 and -6 which may be early indicators of tumor presence. These features are now being assessed in CE-CT scans collected pre- and post-temozolomide treatment in a syngeneic model of mesenchymal GBM. Nevertheless, BLI is significantly more sensitive than CE-CT (either visually or using radiomic-enhanced CT feature extraction) with luciferase-positive tumors detectable at week-1. In conclusion, U87R-Luc2 tumors > 0.4cm3 are only detectable by Week-8 using CE-CT and either CT instrument studied. Nevertheless, radiomic analysis has defined features which may allow for earlier tumor detection at Week-3, thus expanding the utility of CT in the preclinical setting. Overall, this work supports the discovery of putative prognostic pre-clinical CT-derived radiomic signatures which may ultimately be assessed as early disease markers in patient datasets.


2021 ◽  
Vol 21 (8) ◽  
pp. 9844-9851
Author(s):  
Aymen Hlali ◽  
Afef Oueslati ◽  
Hassen Zairi

2008 ◽  
Vol 55 (12) ◽  
pp. 2772-2777 ◽  
Author(s):  
M.E. de Rodriguez ◽  
M. Vera-Isasa ◽  
V.S. del Rio

2017 ◽  
Vol 28 (3) ◽  
pp. e21198 ◽  
Author(s):  
Chia Yew Lee ◽  
Kok Yeow You ◽  
Zulkifly Abbas ◽  
Kim Yee Lee ◽  
Yeng Seng Lee ◽  
...  

Author(s):  
Neeraj Shrivastava ◽  
Jyoti Bharti

Breast cancer is dangerous in women. It is generally found after the symptoms appear. Detecting the breast cancer at an early stage and understanding the treatment are the most important strategies to prevent death from cancer. Generally, for detection of breast cancer, breast Magnetic Resonance Image (MRI) takes place. It is one of the best approaches to detect tumor in women. In this research paper, a combination of selection methods for seed region growing image segmentation is suggested to detect breast tumor. The suggested method has been divided into following parts: First, the pre-processing of breast image is performed. Second, the automatic threshold for binarization process is calculated. Third, the number of seed points and its position in the breast image are determined automatically using density of pixels value. Fourth, a method for calculation of threshold value is proposed for the purpose of region creation in seed region growing. For the evaluation purpose, the proposed method was applied and tested on the RIDER MRI breast dataset from National Biomedical Imaging Archive (NBIA). After the test was performed, it was observed that proposed algorithm gives 90% accuracy, 88% True Negative Fraction, 91% True Positive Fraction, 10% Misclassification Rate, 94% Precision and 86% Relative Overlap which is better than other existing methods. It not only gives better evaluation measure but also provides segmentation method for multiple tumor detection.


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