In commercial cellular networks, like the systems based on direct sequence code division multiple access (DSCDMA), many types of interferences can appear, starting from multi-user interference inside each sector in a cell to interoperator interference. Also unintentional jamming can be present due to co-existing systems at the same band, whereas intentional jamming arises mainly in military applications. Independent Component Analysis (ICA) use as an advanced pre-processing tool for blind suppression of interfering signals in direct sequence spread spectrum communication systems utilizing antenna arrays. The role of ICA is to provide an interference-mitigated signal to the conventional detection. Several ICA algorithms exist for performing Blind Source Separation (BSS). ICA has been used to extract interference signals, but very less literature is available on the performance, that is, how does it behave in communication environment? This needs an evaluation of its performance in communication environment. This chapter evaluates the performance of some major ICA algorithms like Bell and Sejnowski’s infomax algorithm, Cardoso’s Joint Approximate Diagonalization of Eigen matrices (JADE), Pearson-ICA, and Comon’s algorithm in a communication blind source separation problem. Independent signals representing Sub-Gaussian, Super-Gaussian, and mix users, are generated and then mixed linearly to simulate communication signals. Separation performance of ICA algorithms is measured by performance index.