This chapter provides a review of recent progress in gas sensor based on semiconducting metal oxide nanostructure. The response mechanism and development of various methods to enhancement of sensing properties receives the most attention. Theoretical models to explain the effects of morphology, additives, heterostructured composite and UV irradiation on response improvement were studied comprehensively. Investigations have indicated that 1D nanostructured metal oxide with unique geometry and physical properties display superior sensitivity to gas species. Also, the proposed conduction model in gas sensor based on 1D Metal oxide is discussed. Finally, the response mechanism of hierarchical and hollow nanostructures as novel sensing materials is addressed.