Grasping security situation of the Internet of Things (IoT) is useful to work out a scientific and reasonable strategy to defend the IoT security. In the interest of resolving the problems of the security situation sense technology for IoT, a security situation sense model based on artificial immune system for IoT is proposed in this paper. Security threat sense sub-model, formulation mechanism for security threat intensity and security situation assessment sub-model are established. The security threats in the IoT environment are surveyed effectively. Quantitative and accurate assessment for the Real-Time security situation is realized. Theoretical analysis shows that the proposed model is significative of theory and practice.