scholarly journals Bayesian Optimization for Developmental Robotics with Meta-Learning by Parameters Bounds Reduction

Author(s):  
Maxime Petit ◽  
Emmanuel Dellandrea ◽  
Liming Chen
2018 ◽  
pp. 221-239
Author(s):  
Daniela Conti ◽  
Santo Di Nuovo ◽  
Angelo Cangelosi

2020 ◽  
Author(s):  
Jon Uranga ◽  
Lukas Hasecke ◽  
Jonny Proppe ◽  
Jan Fingerhut ◽  
Ricardo A. Mata

The 20S Proteasome is a macromolecule responsible for the chemical step in the ubiquitin-proteasome system of degrading unnecessary and unused proteins of the cell. It plays a central role both in the rapid growth of cancer cells as well as in viral infection cycles. Herein, we present a computational study of the acid-base equilibria in an active site of the human proteasome, an aspect which is often neglected despite the crucial role protons play in the catalysis. As example substrates, we take the inhibition by epoxy and boronic acid containing warheads. We have combined cluster quantum mechanical calculations, replica exchange molecular dynamics and Bayesian optimization of non-bonded potential terms in the inhibitors. In relation to the latter, we propose an easily scalable approach to the reevaluation of non-bonded potentials making use of QM/MM dynamics information. Our results show that coupled acid-base equilibria need to be considered when modeling the inhibition mechanism. The coupling between a neighboring lysine and the reacting threonine is not affected by the presence of the inhibitor.


IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 172859-172868
Author(s):  
Zhengwei Ma ◽  
Sensen Guo ◽  
Gang Xu ◽  
Saddam Aziz

Sensors ◽  
2020 ◽  
Vol 20 (20) ◽  
pp. 5966
Author(s):  
Ke Wang ◽  
Gong Zhang

The challenge of small data has emerged in synthetic aperture radar automatic target recognition (SAR-ATR) problems. Most SAR-ATR methods are data-driven and require a lot of training data that are expensive to collect. To address this challenge, we propose a recognition model that incorporates meta-learning and amortized variational inference (AVI). Specifically, the model consists of global parameters and task-specific parameters. The global parameters, trained by meta-learning, construct a common feature extractor shared between all recognition tasks. The task-specific parameters, modeled by probability distributions, can adapt to new tasks with a small amount of training data. To reduce the computation and storage cost, the task-specific parameters are inferred by AVI implemented with set-to-set functions. Extensive experiments were conducted on a real SAR dataset to evaluate the effectiveness of the model. The results of the proposed approach compared with those of the latest SAR-ATR methods show the superior performance of our model, especially on recognition tasks with limited data.


Sign in / Sign up

Export Citation Format

Share Document