Knowledge Representation of G-Protein-Coupled Receptor Signal Transduction Pathways

2019 ◽  
Author(s):  
Natthawut Kertkeidkachorn ◽  
Lihua Zhao ◽  
Xin Liu ◽  
Ryutaro Ichise
Keyword(s):  
Signal Transduction ◽  
Knowledge Representation ◽  
G Protein ◽  
Signal Transduction Pathways ◽  
G Protein Coupled Receptor ◽  
Receptor Signal ◽  
G Protein Coupled

Effects of vanadium(IV) compounds on plasma membrane lipids lead to G protein-coupled receptor signal transduction

2020 ◽  
Vol 203 ◽  
pp. 110873 ◽  
Author(s):  
Duaa Althumairy ◽  
Heide A. Murakami ◽  
Dongmei Zhang ◽  
B. George Barisas ◽  
Deborah A. Roess ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Plasma Membrane ◽  
G Protein ◽  
Membrane Lipids ◽  
G Protein Coupled Receptor ◽  
Receptor Signal ◽  
G Protein Coupled

The Role of Rho in G Protein-Coupled Receptor Signal Transduction

2000 ◽  
Vol 40 (1) ◽  
pp. 459-489 ◽  
Author(s):  
Valerie P. Sah ◽  
Tammy M. Seasholtz ◽  
Sarah A. Sagi ◽  
Joan Heller Brown
Keyword(s):  
Signal Transduction ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Receptor Signal ◽  
G Protein Coupled

New thoughts on the role of the βγ subunit in G protein signal transduction

2000 ◽  
Vol 78 (5) ◽  
pp. 537-550 ◽  
Author(s):  
Barbara Vanderbeld ◽  
Gregory M Kelly
Keyword(s):  
Signal Transduction ◽  
G Protein ◽  
G Proteins ◽  
G Protein Coupled Receptors ◽  
Limited Information ◽  
Α Subunit ◽  
Downstream Effectors ◽  
Receptor Signal ◽  
G Protein Coupled

Heterotrimeric G proteins are involved in numerous biological processes, where they mediate signal transduction from agonist-bound G-protein-coupled receptors to a variety of intracellular effector molecules and ion channels. G proteins consist of two signaling moieties: a GTP-bound α subunit and a βγ heterodimer. The βγ dimer, recently credited as a significant modulator of G-protein-mediated cellular responses, is postulated to be a major determinant of signaling fidelity between G-protein-coupled receptors and downstream effectors. In this review we have focused on the role of βγ signaling and have included examples to demonstrate the heterogeneity in the heterodimer composition and its implications in signaling fidelity. We also present an overview of some of the effectors regulated by βγ and draw attention to the fact that, although G proteins and their associated receptors play an instrumental role in development, there is rather limited information on βγ signaling in embryogenesis.Key words: G protein, βγ subunit, G-protein-coupled receptor, signal transduction, adenylyl cyclase.

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