Pulse oximeter measurements of oxygen saturation in sickle cell blood

1988 ◽  
Author(s):  
E.C. Walker ◽  
G.P. Rodgers ◽  
C.T. Noguchi ◽  
A.N. Schechter
Keyword(s):  
Oxygen Saturation ◽  
Sickle Cell ◽  
Pulse Oximeter

IoT Based Pulse Oximeter

2021 ◽  
Vol 9 (8) ◽  
pp. 2946-2951
Author(s):  
G Sidhartha
Keyword(s):  
Heart Rate ◽  
Signal Processing ◽  
Oxygen Saturation ◽  
Data Transmission ◽  
Pulse Oximeter ◽  
Mobile Application ◽  
Preventive Measures ◽  
Vital Signs ◽  
Home Treatment ◽  
Portable Devices

Abstract: In recent times, we have realized the importance of vital signs such as Oxygen saturation and heart rate i.e beats per minute (BPM) due to the covid-19 situation worldwide. SpO2 and BPM are being used as preliminary indicators for testing a person’s health, the drop in the oxygen saturation is perceived as one of the symptoms of a person suffering from coronavirus. Oximeters are portable devices that are used to measure the SpO2 and BPM of a person. Timely measurements of oxygen saturation can aid in taking preventive measures. This paper discusses the construction and development of an IoT-based pulse oximeter that is capable of transmitting the reading obtained to any remote location wirelessly. The proposed system uses Arduino as the microcontroller which is used for signal processing and Esp-01 as the Wifi platform to enable remote data transmission. The data is communicated remotely through Blynk mobile application. This project is aimed at reducing the manual effort undergone in regularly updating the oxygen saturation to the doctor, in the case of a person undergoing home treatment. Though an oximeter is not a screening te st, it is a primary indicator of a person’s health. Keywords: Heart rate, SpO2, IoT, Arduino, BLYNK server, Red, IR.

scholarly journals Effect of At-Home Bleaching on Oxygen Saturation Levels in the Dental Pulp of Maxillary Central Incisors

2018 ◽  
Vol 29 (6) ◽  
pp. 541-546 ◽  
Author(s):  
Caroline Solda ◽  
Fernando Branco Barletta ◽  
José Roberto Vanni ◽  
Paula Lambert ◽  
Marcus Vinícius Reis Só ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Pulse Oximeter ◽  
Dental Pulp ◽  
Generalized Estimating Equations ◽  
Carbamide Peroxide ◽  
Baseline Levels ◽  
Student’S T ◽  
Bleaching Treatment ◽  
Student’S T Test ◽  
At Home

Abstract The present study assessed oxygen saturation (SaO2) levels before, during, and after at-home bleaching treatment in the pulps of healthy maxillary central incisors. SaO2 levels were measured in 136 healthy maxillary central incisors using a pulse oximeter. The bleaching protocol consisted of 10% carbamide peroxide gel placed in individual trays and used for four hours daily for 14 days. SaO2 levels were assessed before bleaching (T0), immediately after the first session (T1), on the 7th day of treatment (T2), on the 15th day (the day following the last session) (T3), and 30 days after completion of the bleaching protocol (T4). Data were statistically analyzed using generalized estimating equations (GEE), Student’s t test (p<0.05) and Pearson’s correlation. Mean pulp SaO2 levels were 85.1% at T0, 84.9% at T1, 84.7% at T2, 84.3% at T3, and 85.0% at T4. Gradual reductions in SaO2 levels were observed, with significant differences (p<0.001) during the course of home bleaching treatment. However, 30 days after the end of the bleaching protocol, SaO2 levels returned to baseline levels. Home bleaching caused a reversible transient decrease in SaO2 levels in the pulps.

scholarly journals Automatic Oxygen Delivery System for Premature Babies

2010 ◽  
Vol 4 (2) ◽  
Author(s):  
Thao P. Do ◽  
Lindsey J. Eubank ◽  
Devin S. Coulter ◽  
John M. Freihaut ◽  
Carlos E. Guevara ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Oxygen Concentration ◽  
Delivery System ◽  
Pulse Oximeter ◽  
Oxygen Delivery ◽  
Supplemental Oxygen ◽  
Saturation Level ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Oxygen Saturation Level

When an infant is born prematurely, there are a number of health risks. Among these are underdeveloped lungs, which can lead to abnormal gas exchange of oxygen or hypoxemia. Hypoxemia is treated through oxygen therapy, which involves the delivery of supplemental oxygen to the patient but there are risks associated with this method. Risks include retinopathy, which can cause eye damage when oxygen concentration is too high, and brain damage, when the concentration is too low [1]. Supplemental oxygen concentration must be controlled rigorously. Currently healthcare staff monitors infants’ blood oxygen saturation level using a pulse oximeter. They manually adjust the oxygen concentration using an air-oxygen blender. Inconsistent manual adjustments can produce excessive fluctuations and cause the actual oxygen saturation level to deviate from the target value. Precision and accuracy are compromised. This project develops an automatic oxygen delivery system that regulates the supplemental oxygen concentration to obtain a target blood oxygen saturation level. A microprocessor uses a LABVIEW® program to analyze pulse oximeter and analyzer readings and control electronic valves in a redesigned air-oxygen blender. A user panel receives a target saturation level, displays patient data, and signals alarms when necessary. The prototype construction and testing began February 2010.

scholarly journals Comparison of pulse oximetry and earlobe blood gas with CO-oximetry in children with sickle cell disease: a retrospective review

2020 ◽  
Vol 4 (1) ◽  
pp. e000690
Author(s):  
Michele Arigliani ◽  
Sean Zheng ◽  
Gary Ruiz ◽  
Subarna Chakravorty ◽  
Cara J Bossley ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Oxygen Saturation ◽  
Pulse Oximetry ◽  
Sickle Cell ◽  
Blood Gas ◽  
Cell Disease ◽  
Arterial Blood ◽  
Ambulatory Patients ◽  
The Difference ◽  
Age Range

ObjectivesTo investigate the agreement between pulse oximetry (SpO2) and oxygen saturation (SaO2) measured by CO-oximetry on arterialised earlobe blood gas (EBG) in children and adolescents with sickle cell disease (SCD).Design and settingWe retrospectively reviewed 39 simultaneous and paired SaO2 EBG and SpO2 measurements from 33 ambulatory patients with SCD (32 subjects with Haemoglobin SS and one with Haemoglobin Sß+, 52% male, mean±SD age 11.0±3.6, age range 5–18). Measurements were performed between 2012 and 2015 when participants were asymptomatic. Hypoxaemia was defined as SaO2 ≤93%. A Bland-Altman analysis was performed to assess the accuracy of SpO2 as compared with EBG SaO2.ResultsThe mean±SD SpO2 and SaO2 values in the same patients were, respectively, 93.6%±3.7% and 94.3%±2.9%. The bias SpO2–SaO2 was −0.7% (95% limits of agreement from −5.4% to 4.1%) and precision was 2.5%. In 9/39 (23%) cases, the difference in SpO2–SaO2 was greater than the expected error range ±2%, with SaO2 more often underestimated by SpO2 (6/9), especially at SpO2values ≤93%. Thirteen participants (33%) were hypoxaemic. The sensitivity of SpO2 for hypoxaemia was 100%, specificity 85% and positive predictive value 76%.ConclusionsPulse oximetry was inaccurate in almost a quarter of measurements in ambulatory paediatric patients with SCD, especially at SpO2values ≤93%. In these cases, oxygen saturation can be confirmed through EBG CO-oximetry, which is easier to perform and less painful than traditional arterial blood sampling.

scholarly journals Ektacytometric measurement of sickle cell deformability as a continuous function of oxygen tension [published erratum appears in Blood 1987 Apr;69(4):1272]

Blood ◽  
1987 ◽  
Vol 69 (1) ◽  
pp. 316-323 ◽  
Author(s):  
MP Sorette ◽  
MG Lavenant ◽  
MR Clark
Keyword(s):  
Oxygen Saturation ◽  
Oxygen Tension ◽  
Sickle Cell ◽  
Hemoglobin Concentration ◽  
Exchange System ◽  
Cell Deformability ◽  
Linear Gradient ◽  
Couette Viscometer ◽  
Gas Exchange System

Abstract In an effort to study the rheologic effects of small amounts of hemoglobin S (HbS) polymer in sickle red cells, we have used the ektacytometer, a laser diffraction couette viscometer, to measure sickle cell deformability as a function of oxygen tension. Sickle cell populations of defined intracellular hemoglobin concentration (MCHC) were isolated using Stractan density gradients and were resuspended in buffered polyvinylpyrrolidone solutions for deformability measurements. Using a gas-porous, hollow fiber gas exchange system to establish a linear gradient in oxygen tension, deformability was measured over a pO2 range of 76 to 0 mm Hg. Parallel spectroscopic determinations of oxygen saturation permitted determination of cell deformability as a function of oxygen saturation for each discrete MCHC population. From these measurements the level of oxygen saturation at which a loss in cell deformability was first detected could be defined. Then, using the data of Noguchi and Schecter, the amount of polymerized HbS in the cells at that defined level of oxygen saturation was estimated. The results of this analysis suggested that the quantity of polymer that caused a detectable loss in cell deformability increased with increasing MCHC. In addition, for MCHC above 30 g/dL, this represented a substantial fraction of the total HbS in the cell.

scholarly journals Nocturnal Oxygen Desaturation and Disordered Sleep as a Potential Factor in Executive Dysfunction in Sickle Cell Anemia

2011 ◽  
Vol 18 (1) ◽  
pp. 168-173 ◽  
Author(s):  
Matthew J. Hollocks ◽  
Tessa B. Kok ◽  
Fenella J. Kirkham ◽  
Johanna Gavlak ◽  
Baba P. Inusa ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Oxygen Saturation ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Cognitive Assessment ◽  
Executive Dysfunction ◽  
Oxygen Desaturation ◽  
Sleep Fragmentation ◽  
Hemoglobin Oxygen Saturation ◽  
Neuropsychological Measures

AbstractPrevious research has identified cognitive impairment in children with sickle cell anemia (SCA, Hemoglobin SS) compared with controls, partly accounted for by overt neuropathology after clinical stroke, “covert” (“silent”) infarction, and severity of anemia. However, cognitive deficits have also been identified in children with SCA with no history of stroke and a normal T2-weighted magnetic resonance imaging (MRI) scan. Our aim was to investigate whether nocturnal hemoglobin oxygen desaturation and sleep fragmentation could be associated with cognitive impairment in children with SCA. We assessed 10 children with SCA (9 with normal MRI) using neuropsychological measures of executive function. Cognitive assessment was immediately followed by overnight polysomnography to record nocturnal hemoglobin oxygen saturation and sleep arousals. Decreases in hemoglobin oxygen saturation and/or increased sleep arousals were associated with reduced performance on cognitive assessment. Nocturnal hemoglobin oxygen desaturation and sleep fragmentation may be a contributing factor to executive dysfunction in SCA. (JINS, 2012, 18, 168–173)

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