Propagation of the cardiac action potential from an ectopic focus into a two-dimensional sheet of ventricular cells

2003 ◽  
Author(s):  
R. Wilders ◽  
D.A. Golod ◽  
M.B. Wagner ◽  
R. Kumar ◽  
Y.-G. Wang ◽  
...  
Keyword(s):  
Action Potential ◽  
Cardiac Action Potential ◽  
Two Dimensional ◽  
Cardiac Action ◽  
Ventricular Cells

A new calcium current underlying the plateau of the cardiac action potential

1984 ◽  
Vol 223 (1230) ◽  
pp. 35-48 ◽  
Keyword(s):  
Action Potential ◽  
Calcium Current ◽  
Calcium Currents ◽  
Cardiac Action Potential ◽  
Heart Cells ◽  
Threshold Potential ◽  
Cardiac Action ◽  
Ventricular Cells ◽  
Current Voltage ◽  
Slow Inward Calcium Current

A small and very slow inward calcium current has been identified in isolated single ventricular cells using TTX and Cd 2+ to block the sodium and fast calcium currents. Activation requires about 300 ms at the threshold potential of —60 mV, decreasing to 80 ms at the peak current voltage of —30 mV. Inactivation is five to ten times longer. Half steady-state activation and inactivation are at — 50 and — 45 mV respectively. The current is distinctively different in both its kinetics and pharmacology from the conventional calcium current described in single heart cells. It is proposed that it contributes significant current to help maintain a major portion of the long ventricular action potential.

scholarly journals Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics

2016 ◽  
Vol 594 (9) ◽  
pp. 2537-2553 ◽  
Author(s):  
Yann Prudat ◽  
Roshni V. Madhvani ◽  
Marina Angelini ◽  
Nils P. Borgstom ◽  
Alan Garfinkel ◽  
...  
Keyword(s):  
Action Potential ◽  
Cardiac Action Potential ◽  
Cardiac Action

scholarly journals Dynamics of the late Na+ current during cardiac action potential and its contribution to afterdepolarizations

2013 ◽  
Vol 64 ◽  
pp. 59-68 ◽  
Author(s):  
Balazs Horvath ◽  
Tamas Banyasz ◽  
Zhong Jian ◽  
Bence Hegyi ◽  
Kornel Kistamas ◽  
...  
Keyword(s):  
Action Potential ◽  
Cardiac Action Potential ◽  
Na Current ◽  
Cardiac Action
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