Impact of Superoxide Dismutase on Nitric Oxide and Peroxynitrite Levels in the Microcirculation - A Computational Model

2007 ◽  
Author(s):  
Miriam Defibaugh Chavez ◽  
Nisha Lakshmanan ◽  
Mahendra Kavdia
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Computational Model

Nitric Oxide and Blood Pressure in Mice Lacking Extracellular-Superoxide Dismutase

2002 ◽  
Vol 36 (7) ◽  
pp. 755-758 ◽  
Author(s):  
Lena M. Jonsson ◽  
Daryl D. Rees ◽  
Thomas Edlund ◽  
Stefan L. Marklund
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Superoxide Dismutase ◽  
Extracellular Superoxide Dismutase

Effects of superoxide dismutase on nitric oxide production during reperfusion after focal cerebral ischemia in rats

1995 ◽  
Vol 200 (2) ◽  
pp. 137-140 ◽  
Author(s):  
Eiji Kumura ◽  
Toshiki Yoshimine ◽  
Shigeki Kubo ◽  
Satonori Tanaka ◽  
Toru Hayakawa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Nitric Oxide Production ◽  
Oxide Production

Recombinant Human Superoxide Dismutase Enhances the Effect of Inhaled Nitric Oxide in Persistent Pulmonary Hypertension

2001 ◽  
Vol 164 (5) ◽  
pp. 834-839 ◽  
Author(s):  
ROBIN H. STEINHORN ◽  
GEORGE ALBERT ◽  
DANIEL D. SWARTZ ◽  
JAMES A. RUSSELL ◽  
CAROLYN R. LEVINE ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Superoxide Dismutase ◽  
Inhaled Nitric Oxide ◽  
Persistent Pulmonary Hypertension

Hypothalamic superoxide dismutase, xanthine oxidase, nitric oxide, and malondialdehyde in rats fed with fish ω-3 fatty acids

2004 ◽  
Vol 28 (4) ◽  
pp. 693-698 ◽  
Author(s):  
Ahmet Songur ◽  
Mustafa Sarsilmaz ◽  
Sadik Sogut ◽  
Birsen Ozyurt ◽  
Huseyin Ozyurt ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Fatty Acids ◽  
Superoxide Dismutase ◽  
Xanthine Oxidase

Are Superoxide Dismutase 2 and Nitric Oxide Synthase Polymorphisms Associated with Idiopathic Infertility?

2014 ◽  
Vol 21 (4) ◽  
pp. 565-569 ◽  
Author(s):  
Celine Faure ◽  
Pauline Leveille ◽  
Charlotte Dupont ◽  
Chantal Julia ◽  
Pascale Chavatte-Palmer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Nitric Oxide Synthase ◽  
Idiopathic Infertility ◽  
Oxide Synthase ◽  
Superoxide Dismutase 2

Effects of endothelium-derived relaxing factor and nitric oxide on rat mesangial cells

1990 ◽  
Vol 258 (1) ◽  
pp. F162-F167 ◽  
Author(s):  
P. J. Shultz ◽  
A. E. Schorer ◽  
L. Raij
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Mesangial Cells ◽  
Specific Inhibitor ◽  
Ang Ii ◽  
Glomerular Mesangial Cells ◽  
Functional Responses ◽  
Cross Sectional ◽  
Relaxing Factor ◽  
Endothelium Derived Relaxing Factor

We have investigated whether endothelium-derived relaxing factor (EDRF) and nitric oxide (NO), a substance proposed to be one of the EDRFs, could elicit biochemical and biological responses in rat glomerular mesangial cells (MC). In wells with MC alone, guanosine 3',5'-cyclic monophosphate (cGMP) levels were 2.6 +/- 0.6 fmol/microgram protein, and bradykinin did not affect these levels, whereas in coincubation experiments with bovine aortic EC and rat MC, cGMP levels in MC increased to 44.6 +/- 21 fmol/micrograms protein after bradykinin stimulation (P less than 0.05). This effect was potentiated by superoxide dismutase and inhibited by hemoglobin and L-NG-monomethyl arginine, a specific inhibitor of EDRF synthesis. Increases in cGMP were also observed when MC were incubated directly with NO and were potentiated by superoxide dismutase and inhibited by hemoglobin. We also tested whether NO could inhibit angiotensin II (ANG II)-induced reductions in cross-sectional area (CSA) of MC. When MC were exposed to ANG II only, 65% of the cells underwent a significant reduction in CSA, as measured by digital image analysis. However, when MC were incubated with ANG II and NO, only 10% of cells responded (P less than 0.04). These studies demonstrate that EDRF and NO induce significant biochemical and functional responses in rat glomerular MC and suggest that communication between EC and MC may be important in regulation of glomerular function.

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