scholarly journals Modulation of the hydration water around monoclonal antibodies on addition of excipients detected by terahertz-time domain spectroscopy

2015 ◽  
Author(s):  
Vincent P. Wallace ◽  
Shahid Uddin ◽  
Christopher F. van der Walle ◽  
Robert J. Falconer ◽  
J. Axel Zeitler
Keyword(s):  
Monoclonal Antibodies ◽  
Time Domain ◽  
Hydration Water ◽  
Terahertz Time Domain Spectroscopy ◽  
Time Domain Spectroscopy

scholarly journals Modulation of the Hydration Water Around Monoclonal Antibodies on Addition of Excipients Detected by Terahertz Time-Domain Spectroscopy

2015 ◽  
Vol 104 (12) ◽  
pp. 4025-4033 ◽  
Author(s):  
Vincent P. Wallace ◽  
Denis Ferachou ◽  
Peng Ke ◽  
Katie Day ◽  
Shahid Uddin ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Time Domain ◽  
Hydration Water ◽  
Terahertz Time Domain Spectroscopy ◽  
Time Domain Spectroscopy

scholarly journals Salt effects on the picosecond dynamics of lysozyme hydration water investigated by terahertz time-domain spectroscopy and an insight into the Hofmeister series for protein stability and solubility

2016 ◽  
Vol 18 (22) ◽  
pp. 15060-15069 ◽  
Author(s):  
Katsuyoshi Aoki ◽  
Kentaro Shiraki ◽  
Toshiaki Hattori
Keyword(s):  
Aqueous Solutions ◽  
Protein Stability ◽  
Time Domain ◽  
Protein Solubility ◽  
Hydration Water ◽  
Hofmeister Series ◽  
Terahertz Time Domain Spectroscopy ◽  
Salt Effects ◽  
Time Domain Spectroscopy ◽  
Insight Into

The addition of salts into protein aqueous solutions causes changes in protein solubility and stability, the ability of which is known to be ordered in the Hofmeister series.

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