<div><div><div><p>Motion capture systems are widely accepted as ground-truth for gait analysis and are used for the validation of other gait analysis systems.To date, their reliability and limitations in manual labeling of gait events have not been studied.</p><p><b>Objectives</b>: Evaluate human manual labeling uncertainty and introduce a new hybrid gait analysis model for long-term monitoring.</p><p><b>Methods</b>: Evaluate and estimate inter-labeler inconsistencies by computing the limits-of-agreement; develop a model based on dynamic time warping and convolutional neural network to identify a valid stride and eliminate non-stride data in walking inertial data collected by a wearable device; Gait events are detected within a valid stride region afterwards; This method makes the subsequent data computation more efficient and robust.</p><p><b>Results</b>: The limits of inter-labeler agreement for key</p><p>gait events of heel off, toe off, heel strike, and flat foot are 72 ms, 16 ms, 22 ms, and 80 ms, respectively; The hybrid model's classification accuracy for a stride and a non-stride are 95.16% and 84.48%, respectively; The mean absolute error for detected heel off, toe off, heel strike, and flat foot are 24 ms, 5 ms, 9 ms, and 13 ms, respectively.</p><p><b>Conclusions</b>: The results show the inherent label uncertainty and the limits of human gait labeling of motion capture data; The proposed hybrid-model's performance is comparable to that of human labelers and it is a valid model to reliably detect strides in human gait data.</p><p><b>Significance</b>: This work establishes the foundation for fully automated human gait analysis systems with performances comparable to human-labelers.</p></div></div></div>
Human Gait Analysis in Neurodegenerative Diseases: a Review