Topological Descriptors of Gait Nonlinear Dynamics toward Freezing-of-Gait Episodes Recognition in Parkinson’s Disease

Objective: To conduct a systematic review evaluating the effects of music-based movement therapy on motor function, balance, gait, mental health, and quality of life among individuals with Parkinson’s disease. Data sources: A systematic search of PubMed, Embase, Cochrane Library, Web of Science, PsycINFO, CINAHL, and Physiotherapy Evidence Database was carried out to identify eligible papers published up to December 10, 2020. Review methods: Literature selection, data extraction, and methodological quality assessment were independently performed by two investigators. Publication bias was determined by funnel plot and Egger’s regression test. “Trim and fill” analysis was performed to adjust any potential publication bias. Results: Seventeen studies involving 598 participants were included in this meta-analysis. Music-based movement therapy significantly improved motor function (Unified Parkinson’s Disease Rating Scale motor subscale, MD = −5.44, P = 0.002; Timed Up and Go Test, MD = −1.02, P = 0.001), balance (Berg Balance Scale, MD = 2.02, P < 0.001; Mini-Balance Evaluation Systems Test, MD = 2.95, P = 0.001), freezing of gait (MD = −2.35, P = 0.039), walking velocity (MD = 0.18, P < 0.001), and mental health (SMD = −0.38, P = 0.003). However, no significant effects were observed on gait cadence, stride length, and quality of life. Conclusion: The findings of this study show that music-based movement therapy is an effective treatment approach for improving motor function, balance, freezing of gait, walking velocity, and mental health for patients with Parkinson’s disease.

Attention switching deficit in patients of Parkinson’s disease who experience freezing of gait

Applied Neuropsychology Adult ◽

10.1080/23279095.2021.1951268 ◽

2021 ◽

pp. 1-12

Author(s):

Moulika Mandal ◽

Azizuddin Khan

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Freezing Of Gait ◽

Attention Switching

1 Application of neural network to detect freezing of gait in patients with Parkinson’s disease

Soft Computing ◽

10.1515/9783110628616-001 ◽

2020 ◽

pp. 1-12

Keyword(s):

Neural Network ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Freezing Of Gait

Use of Botulinum Neurotoxin in Parkinson’s Disease: A Critical Appraisal

Toxins ◽

10.3390/toxins13020087 ◽

2021 ◽

Vol 13 (2) ◽

pp. 87

Author(s):

Wolfgang H. Jost

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Botulinum Neurotoxin ◽

Critical Appraisal ◽

Freezing Of Gait ◽

Sufficient Data ◽

Pisa Syndrome ◽

Focal Hyperhidrosis ◽

Detrusor Hyperactivity ◽

Important Indication

For well over 30 years, the botulinum neurotoxin (BoNT) has been used for a large number of indications, some of which however have not been licensed. Admittedly, approval varies in many countries and this permits a large spectrum for evaluation. Thus, BoNT is used for patients with Parkinson’s disease (PD) and other Parkinson’s syndromes (PS) in varying degrees of frequency. We have to distinguish between (1) indications that are either approved or (2) those not approved, (3) indications that might be a result of PS and (4) finally those which appear independent of PS. The most important indication for BoNT in PS patients is probably sialorrhea, for which approval has been granted in the majority of countries. Cervical dystonia is a frequent symptom in PS, with anterocollis as a specific entity. A further indication is blepharospasm in the different forms, especially the inhibition of eyelid opening in atypical PS. The use of BoNT in cases of camptocormia, the Pisa syndrome and neck rigidity is still a matter of debate. In dystonia of the extremities BoNT can be recommended, especially in dystonia of the feet. One well-known indication, for which however sufficient data are still lacking, involves treating tremor with BoNT. As to autonomic symptoms: Focal hyperhidrosis and detrusor hyperactivity can be mentioned, in this last case BoNT has already been approved. A number of further but rare indications such as freezing-of-gait, dyskinesia, and dysphagia will be discussed and evaluated.

Freezing of Gait in Parkinson's Disease: Invasive and Noninvasive Neuromodulation

Neuromodulation Technology at the Neural Interface ◽

10.1111/ner.13347 ◽

2020 ◽

Author(s):

Shervin Rahimpour ◽

Wendy Gaztanaga ◽

Amol P. Yadav ◽

Stephano J. Chang ◽

Max O. Krucoff ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Freezing Of Gait ◽

Noninvasive Neuromodulation