A Dense Magnetic Coil Array with Multi-locus and Multi-site Patterning

<p>· We propose multi-loci and multi-site current patterning (sequential or simultaneous) for precise, rapid and repeatable steering for improved neuronal targeting.</p><p>· Here we demonstrate these improvements by using a unique pixel cell for excitation synthesis as enabled by a three-layer dense magnetic coil array that is mapped to a hexagonal grid with cubic coordinates.</p><p>· We validate the theory with supporting simulations, experimental results and a scalable electronics design that can address a relevant range of larger coil diameters, higher power levels and topologies.</p><p><a></a></p><p>· Precise, rapid and repeatable patterns potentially offer new modalities for noninvasive neuromodulation (suprathreshold and subthreshold) and adjacent biomagnetic applications such as tumor cell membrane disruption [1], and magnetic drug delivery [2].</p>

A Dense Magnetic Coil Array with Multi-locus and Multi-site Patterning

<p>· We propose multi-loci and multi-site current patterning (sequential or simultaneous) for precise, rapid and repeatable steering for improved neuronal targeting.</p><p>· Here we demonstrate these improvements by using a unique pixel cell for excitation synthesis as enabled by a three-layer dense magnetic coil array that is mapped to a hexagonal grid with cubic coordinates.</p><p>· We validate the theory with supporting simulations, experimental results and a scalable electronics design that can address a relevant range of larger coil diameters, higher power levels and topologies.</p><p><a></a></p><p>· Precise, rapid and repeatable patterns potentially offer new modalities for noninvasive neuromodulation (suprathreshold and subthreshold) and adjacent biomagnetic applications such as tumor cell membrane disruption [1], and magnetic drug delivery [2].</p>

Brazilian research on noninvasive brain stimulation applied to health conditions

ABSTRACT Background: Brazil has a top position regarding scientific production on noninvasive neuromodulation worldwide. Knowledge of scientometric phenomena involving Brazilian researchers who produce science on this theme may aid confidence in Brazilian clinical and research professionals. Objective: To investigate the scenario of research on the theme of noninvasive neuromodulation in Brazil. Methods: This was a scientometric study for mapping scientific production on this subject involving network phenomena, the professions of researchers, institutional affiliation, main research unit, total number of scientific articles on noninvasive neuromodulation published in journals, research sub-area and year of obtaining the PhD title. Public data from Lattes Platform curricula vitae and from VOSViewer© were used. Results: A total of 54 Brazilian researchers were identified, of whom 16 are research productivity fellows. Most of them are linked to institutions in southeastern Brazil, involving the professions of biology, biochemistry, physical education, physiotherapy, speech therapy, gerontology, medicine and psychology, with 1175 articles published in journals. These studies involve experimental animal and human models to account for mechanisms, observational studies, case reports, randomized clinical trials, systematic reviews, meta-analyses, product and process development, computer modeling and guidelines. Conclusions: Brazil occupies a prominent place in the world scenario of research on noninvasive neuromodulation, which is used by different professions for treatment of brain dysfunctions, with a trend towards expansion to other fields.

Peroneal Electric Transcutaneous NeuroModulation (eTNM®): A Novel Method for the Treatment of the Overactive Bladder

Overactive bladder syndrome (OAB) is a prevalent medical problem with a significant impact on the quality of life of the affected individuals. Pharmacotherapy is considered the main treatment method, although it is discontinued in a significant proportion of patients due to inefficacy or associated side effects. If pharmacotherapy fails, patients can undergo peripheral neuromodulation of the somatic nerves of the lower limb or sacral neuromodulation; however, neither of these represents an ideal therapeutic tool. The Peroneal electric Transcutaneous NeuroModulation (Peroneal eTNM®), based on the selective stimulation of the peroneal nerve, is the new fully noninvasive neuromodulation method intended to treat OAB. The URIS® neuromodulation system, engineered to provide Peroneal eTNM®, consists of the URIS® device, URIS® active electrodes, and the biofeedback foot sensor (BFS). The unique design of the URIS® device and URIS® active electrodes allows for the use of a low voltage and current during neuromodulation, which significantly reduces the unpleasant sensations. The BFS allows for precise localization of the active electrodes and for continuous adjustment of the voltage and frequency to achieve the optimal therapeutic effect. The URIS® system adopts several principles of telemedicine, which makes it compatible with the US Food and Drug Administration (FDA) and European Union (EU) regulations for home-based use. This article describes both the Peroneal eTNM® method and the URIS® neuromodulation system, including its technical specifications and data from laboratory testing. Preclinical and early clinical data demonstrate the feasibility of this new method for noninvasive OAB treatment and possible implications for clinical practice.

Application of noninvasive neuromodulation in patients with asthenic neurosis

The relevance of the work is associated with the high prevalence and socio-economic significance of neurotic disorders associated with stress. Standards of medical care for patients with neurotic disorders associated with stress do not provide for the use of any physiotherapy or hardware effects. Drug therapy is mainly used, but its use is not always effective and is limited by the risk of developing allergies, drug addiction, toxic manifestations, side effects, etc. Therefore, more and more attention has been paid to non-drug treatment methods recently. Non-invasive neuromodulation is a therapeutic exogenous effect on various parts of the nervous system using an electromagnetic physical factor in the conditions of drug therapy. Purpose. Study the effectiveness of noninvasive neuromodulation in patients with asthenic neurosis. Material and methods. A total of 79 patients with the diagnosis of F48.0 Neurasthenia were studied (59 women and 20 men). The median age was 44 4.5 years. The main group 49 patients, 30 patients made up the control group. The course of non-invasive neuromodulation was performed against the background of medical treatment in accordance with the MES with the use of a pulse generator "TETOS" with feedback in the form of electroencephalography (registration certificate no.FRS2011/11198). Results. Immediately after the end of the course of treatment, 80% of patients manage to achieve a significant improvement in their subjective state. As a result of the proposed method, not only significant, but also persistent improvement in the condition of patients is achieved. Conclusions. The basis of this method is the interaction of two methods of treatment: physiotherapy and medication. As a result of the application of the proposed method, the main cause of the disease (psychotraumatic factor, life circumstances, etc.) is gradually identified, and the patient himself becomes aware of it, with subsequent correction of the condition. As a result, not only significant, but also persistent improvement in the condition of patients is achieved. According to the results of observations of the authors of the application, the disease does not resume for 1.52 years.