scholarly journals Permanent-magnetically Amplified Brake Mechanism Compensated and Stroke-Shortened by a Multistage Nonlinear Spring

Author(s):  
Tori Shimizu ◽  
Kenjiro Tadakuma ◽  
Masahiro Watanabe ◽  
Kazuki Abe ◽  
Masashi Konyo ◽  
...  
Keyword(s):  
2013 ◽  
Vol 26 (5) ◽  
pp. 892-899 ◽  
Author(s):  
Haitao Yu ◽  
Mantian Li ◽  
Hegao Cai
Keyword(s):  

2013 ◽  
Vol 200 (6) ◽  
pp. 757-772 ◽  
Author(s):  
Andrew D. Stephens ◽  
Rachel A. Haggerty ◽  
Paula A. Vasquez ◽  
Leandra Vicci ◽  
Chloe E. Snider ◽  
...  

The mechanisms by which sister chromatids maintain biorientation on the metaphase spindle are critical to the fidelity of chromosome segregation. Active force interplay exists between predominantly extensional microtubule-based spindle forces and restoring forces from chromatin. These forces regulate tension at the kinetochore that silences the spindle assembly checkpoint to ensure faithful chromosome segregation. Depletion of pericentric cohesin or condensin has been shown to increase the mean and variance of spindle length, which have been attributed to a softening of the linear chromatin spring. Models of the spindle apparatus with linear chromatin springs that match spindle dynamics fail to predict the behavior of pericentromeric chromatin in wild-type and mutant spindles. We demonstrate that a nonlinear spring with a threshold extension to switch between spring states predicts asymmetric chromatin stretching observed in vivo. The addition of cross-links between adjacent springs recapitulates coordination between pericentromeres of neighboring chromosomes.


2015 ◽  
Vol 14 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Si-Hoon Lee ◽  
Ju-Hyung Lee ◽  
Xuan Nghiem Tran ◽  
Sung-Ryul Kim

2018 ◽  
Vol 11 (1) ◽  
pp. 1-22
Author(s):  
Y. A. Amer ◽  
A. T. EL-Sayed ◽  
Sahar. He. Younis ◽  
A. M. Salem

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