According to the existing problems and shortcomings of the manufacturing enterprise quality management, integrating with enterprises’ new needs of quality management in the recent implementation of QHSE( Quality, Health, Safety, and Environment) system, this paper built an EII( Enterprise Information Integration)- Oriented QMS( Quality Management System) model, discussed the integrating problems involved in the system, then proposed the overall EII model. By analyzing the information integration relations between QMS and other enterprise applications, this paper put forward some practical ideas and principles of system integration, then built the framework of EII- Oriented QMS solutions. The aim of this paper is making full use of quality information, improving the quality of management and control, and helping manufacturing enterprises to better understand what EII- Oriented QMS is and how to make it a successful project.