A modified computational model of ant colony system in DNA sequence design

Author(s):  
Seri Mastura Mustaza ◽  
Amar Faiz Zainal Abidin ◽  
Zuwairie Ibrahim ◽  
Mohammad Amir Shamsudin ◽  
Abdul Rashid Husain ◽  
...  
Author(s):  
Tri Basuki Kurniawan ◽  
Noor Khafifah Khalid ◽  
Zuwairie Ibrahim ◽  
Marzuki Khalid ◽  
Martin Middendorf

Author(s):  
Soo-Yong Shin ◽  
In-Hee Lee ◽  
Byoung-Tak Zhang

Finding reliable and efficient DNA sequences is one of the most important tasks for successful DNArelated experiments such as DNA computing, DNA nano-assembly, DNA microarrays and polymerase chain reaction. Sequence design involves a number of heterogeneous and conflicting design criteria. Also, it is proven as a class of NP problems. These suggest that multi-objective evolutionary algorithms (MOEAs) are actually good candidates for DNA sequence optimization. In addition, the characteristics of MOEAs including simple addition/deletion of objectives and easy incorporation of various existing tools and human knowledge into the final decision process could increase the reliability of final DNA sequence set. In this chapter, we review multi-objective evolutionary approaches to DNA sequence design. In particular, we analyze the performance of e-multi-objective evolutionary algorithms on three DNA sequence design problems and validate the results by showing superior performance to previous techniques.


2012 ◽  
Vol 13 (1) ◽  
pp. 138 ◽  
Author(s):  
Alfred Kick ◽  
Martin Bönsch ◽  
Michael Mertig

2020 ◽  
Vol 36 (16) ◽  
pp. 4508-4509 ◽  
Author(s):  
Valentin Zulkower ◽  
Susan Rosser

Abstract Motivation Accounting for biological and practical requirements in DNA sequence design often results in challenging optimization problems. Current software solutions are problem-specific and hard to combine. Results DNA Chisel is an easy-to-use, easy-to-extend sequence optimization framework allowing to freely define and combine optimization specifications via Python scripts or Genbank annotations. Availability and implementation The framework is available as a web application (https://cuba.genomefoundry.org/sculpt_a_sequence) or open-source Python library (see at https://github.com/Edinburgh-Genome-Foundry/DNAChisel for code and documentation). Supplementary information Supplementary data are available at Bioinformatics online.


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