Effect of unfractionated heparin on endothelial glycocalyx in a septic shock model

2014 ◽  
Vol 59 (2) ◽  
pp. 160-169 ◽  
Author(s):  
S. YINI ◽  
Z. HENG ◽  
A. XIN ◽  
M. XIAOCHUN
Keyword(s):  
Septic Shock ◽  
Unfractionated Heparin ◽  
Endothelial Glycocalyx ◽  
Shock Model

scholarly journals Unfractionated Heparin Improves the Intestinal Microcirculation in a Canine Septic Shock Model

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Heng Zhang ◽  
Yini Sun ◽  
Xin An ◽  
Xiaochun Ma
Keyword(s):  
Septic Shock ◽  
Unfractionated Heparin ◽  
Flow Index ◽  
Shock Model ◽  
Microcirculatory Perfusion ◽  
Basic Therapy ◽  
E Coli ◽  
Intestinal Microcirculation ◽  
Hemodynamic Variables ◽  
Lactate Levels

Background. Alterations of microcirculation are associated with organ hypoperfusion and high mortality in septic shock. This study is aimed at investigating the effects of unfractionated heparin (UFH) on intestinal microcirculatory perfusion and systemic circulation in a septic shock model. Methods. Twenty-four beagle dogs were randomly allocated into four groups: (a) sham group: healthy controls, (b) shock group: septic shock induced by Escherichia coli, (c) basic therapy group: septic shock animals treated with antibiotics and 10 ml/kg/h saline, and (d) heparin group: septic shock animals treated with basic therapy plus UFH. Hemodynamic variables were measured within 24 h after E. coli administration. The intestinal microcirculation was simultaneously investigated with a sidestream dark-field imaging technique. Additionally, the function of vital organs was evaluated at 12 h postadministration (T12). Results. E. coli induced a progressive septic shock in which the mean arterial pressure (MAP) decreased and lactate levels sharply increased, accompanied by deteriorated microvessel perfusion. While basic therapy partially improved the microvascular flow index and the perfused microvessel density in the jejunal villi, UFH significantly restored major microcirculation variables at T12. Physiological variables, including MAP, urine output, and lactate levels, were improved by UFH, whereas some hemodynamic indices were not affected by UFH. With respect to organ function, UFH increased the platelet count and decreased the creatinine level. Conclusions. UFH improves microcirculatory perfusion of the small intestine independently of the changes in systemic hemodynamic variables in a canine model of septic shock, thereby improving coagulation and renal function.

Blood volume measurements using an integrated fiberoptic monitoring system in a porcine septic shock model

2006 ◽  
Vol 34 (5) ◽  
pp. 1483-1488 ◽  
Author(s):  
Gernot Marx ◽  
Tobias Schuerholz ◽  
Samantha Pedder ◽  
Tim Simon ◽  
Stephen Grime ◽  
...  
Keyword(s):  
Septic Shock ◽  
Monitoring System ◽  
Blood Volume ◽  
Shock Model ◽  
Volume Measurements

Skeletal muscle oedema and muscle fibre necrosis during septic shock. Observations with a porcine septic shock model

1994 ◽  
Vol 424 (6) ◽  
Author(s):  
S. Hauptmann ◽  
B. Klosterhalfen ◽  
J. Weis ◽  
C. Mittermayer ◽  
C.J. Kirkpatrick
Keyword(s):  
Skeletal Muscle ◽  
Septic Shock ◽  
Muscle Fibre ◽  
Shock Model

scholarly journals Degradation of endothelial glycocalyx provides new insights in the pathogenesis of septic shock microvascular failure

Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 2) ◽  
pp. P19
Author(s):  
R Nevière ◽  
R Favory ◽  
X Marechal
Keyword(s):  
Septic Shock ◽  
Endothelial Glycocalyx

scholarly journals Protective effect of CDP-choline on hypotension and tissue injury in septic shock model

2017 ◽  
Vol 64 (2) ◽  
pp. 103-110 ◽  
Author(s):  
SEVİM Çiğdem; ALTINBAŞ
Keyword(s):  
Septic Shock ◽  
Protective Effect ◽  
Tissue Injury ◽  
Shock Model

Characterization of Circular RNA and microRNA Profiles in Septic Myocardial Depression: a Lipopolysaccharide-Induced Rat Septic Shock Model

Inflammation ◽  
2019 ◽  
Vol 42 (6) ◽  
pp. 1990-2002 ◽  
Author(s):  
Tie-Ning Zhang ◽  
Ni Yang ◽  
Julie E. Goodwin ◽  
Kali Mahrer ◽  
Da Li ◽  
...  
Keyword(s):  
Septic Shock ◽  
Circular Rna ◽  
Shock Model ◽  
Myocardial Depression

scholarly journals Fasciola hepatica GST downregulates NF-κB pathway effectors and inflammatory cytokines while promoting survival in a mouse septic shock model

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Vasti Aguayo ◽  
Bianca N. Valdés Fernandez ◽  
Madeline Rodríguez-Valentín ◽  
Caleb Ruiz-Jiménez ◽  
Marcos J. Ramos-Benítez ◽  
...  
Keyword(s):  
Septic Shock ◽  
Inflammatory Cytokines ◽  
Fasciola Hepatica ◽  
Shock Model

scholarly journals Caspase-8 inhibition represses initial human monocyte activation in septic shock model

Oncotarget ◽  
2016 ◽  
Vol 7 (25) ◽  
pp. 37456-37470 ◽  
Author(s):  
Maria Jose Oliva-Martin ◽  
Luis Ignacio Sanchez-Abarca ◽  
Johanna Rodhe ◽  
Alejandro Carrillo-Jimenez ◽  
Pinelopi Vlachos ◽  
...  
Keyword(s):  
Septic Shock ◽  
Human Monocyte ◽  
Caspase 8 ◽  
Shock Model ◽  
Monocyte Activation
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