scholarly journals Rehabilitation Training Using Complex Motor Learning Rescues Deficits in Eyeblink Classical Conditioning in Female Rats Induced by Binge-Like Neonatal Alcohol Exposure

2013 ◽  
Vol 37 (9) ◽  
pp. 1561-1570 ◽  
Author(s):  
Jennifer L. Wagner ◽  
Anna Y. Klintsova ◽  
William T. Greenough ◽  
Charles R. Goodlett
Keyword(s):  
Motor Learning ◽  
Classical Conditioning ◽  
Alcohol Exposure ◽  
Female Rats ◽  
Rehabilitation Training ◽  
Complex Motor ◽  
Neonatal Alcohol Exposure

scholarly journals Effects of neonatal alcohol exposure on vasoactive intestinal polypeptide neurons in the rat suprachiasmatic nucleus

Alcohol ◽  
2009 ◽  
Vol 43 (5) ◽  
pp. 387-396 ◽  
Author(s):  
Yuhua Z. Farnell ◽  
Gregg C. Allen ◽  
Nichole Neuendorff ◽  
James R. West ◽  
A. Chen Wei-Jung ◽  
...  
Keyword(s):  
Suprachiasmatic Nucleus ◽  
Vasoactive Intestinal Polypeptide ◽  
Alcohol Exposure ◽  
Neonatal Alcohol Exposure ◽  
Intestinal Polypeptide

scholarly journals Dual contributions of cerebellar-thalamic networks to learning and offline consolidation of a complex motor task

2020 ◽  
Author(s):  
Andres P Varani ◽  
Romain W Sala ◽  
Caroline Mailhes-Hamon ◽  
Jimena L Frontera ◽  
Clément Léna ◽  
...  
Keyword(s):  
Motor Learning ◽  
Motor Task ◽  
Cerebellar Nuclei ◽  
Specific Inhibition ◽  
Thalamic Nuclei ◽  
Related Information ◽  
Midline Thalamus ◽  
Ventral Thalamus ◽  
Complex Motor ◽  
Offline Processing

SUMMARYThe contribution of cerebellum to motor learning is often considered to be limited to adaptation, a short-timescale tuning of reflexes and previous learned skills. Yet, the cerebellum is reciprocally connected to two main players of motor learning, the motor cortex and the basal ganglia, via the ventral and midline thalamus respectively. Here, we evaluated the contribution of cerebellar neurons projecting to these thalamic nuclei in a skilled locomotion task in mice. In the cerebellar nuclei, we found task-specific neuronal activities during the task, and lasting changes after the task suggesting an offline processing of task-related information. Using pathway-specific inhibition, we found that dentate neurons projecting to the midline thalamus contribute to learning and retrieval, while interposed neurons projecting to the ventral thalamus contribute to the offline consolidation of savings. Our results thus show that two parallel cerebello-thalamic pathways perform distinct computations operating on distinct timescales in motor learning.

scholarly journals Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex.

2018 ◽  
Vol 132 (6) ◽  
pp. 497-511 ◽  
Author(s):  
Sarah A. Jablonski ◽  
Patrese A. Robinson-Drummer ◽  
William B. Schreiber ◽  
Arun Asok ◽  
Jeffrey B. Rosen ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Mrna Expression ◽  
Alcohol Exposure ◽  
Facilitation Effect ◽  
Juvenile Rats ◽  
Neonatal Alcohol Exposure

Structural Stability within the Lateral Cerebellar Nucleus of the Rat Following Complex Motor Learning

1998 ◽  
Vol 69 (3) ◽  
pp. 290-306 ◽  
Author(s):  
Jeffrey A. Kleim ◽  
Michelle A. Pipitone ◽  
Cheryl Czerlanis ◽  
William T. Greenough
Keyword(s):  
Motor Learning ◽  
Structural Stability ◽  
Cerebellar Nucleus ◽  
Complex Motor

scholarly journals Neonatal Alcohol Exposure Induces Long-Lasting Impairment of Visual Cortical Plasticity in Ferrets

2003 ◽  
Vol 23 (31) ◽  
pp. 10002-10012 ◽  
Author(s):  
Alexandre E. Medina ◽  
Thomas E. Krahe ◽  
David M. Coppola ◽  
Ary S. Ramoa
Keyword(s):  
Cortical Plasticity ◽  
Alcohol Exposure ◽  
Neonatal Alcohol Exposure ◽  
Visual Cortical

scholarly journals Exercise and the Brain: Angiogenesis in the Adult Rat Cerebellum after Vigorous Physical Activity and Motor Skill Learning

1992 ◽  
Vol 12 (1) ◽  
pp. 110-119 ◽  
Author(s):  
Krystyna R. Isaacs ◽  
Brenda J. Anderson ◽  
Adriana A. Alcantara ◽  
James E. Black ◽  
William T. Greenough
Keyword(s):  
Motor Learning ◽  
Motor Skill ◽  
Volume Fraction ◽  
Vigorous Physical Activity ◽  
Molecular Layer ◽  
Learning Task ◽  
Skill Learning ◽  
Female Rats ◽  
Motor Skill Learning ◽  
Diffusion Distance

This study compared the morphology of cerebellar cortex in adult female rats exposed for 1 month to repetitive exercise, motor learning, or an inactive condition. In the exercise conditions, rats that were run on a treadmill or housed with access to a running wheel had a shorter diffusion distance from blood vessels in the molecular layer of the paramedian lobule when compared to rats housed individually or rats that participated in a motor skill learning task. Rats taught complex motor skills substantially increased the volume of the molecular layer per Purkinje neuron and increased blood vessel number sufficiently to maintain the diffusion distance. These results dissociate angiogenesis associated with increased neuropil volume (as seen in the motor learning group) from angiogenesis associated with increased metabolic demands (as seen in the exercise groups). While the volume fraction of mitochondria did not differ among groups, the mitochondrial volume fraction per Purkinje cell was significantly increased in the motor skill rats. This appears to parallel the previously reported increase in synapses and associated neuropil volume change.

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