scholarly journals Lithium concentration and recurrence risk during maintenance treatment of bipolar disorder: multicenter cohort and meta‐analysis

2021 ◽  
Author(s):  
Chih‐Wei Hsu ◽  
Andre F. Carvalho ◽  
Shang‐Ying Tsai ◽  
Liang‐Jen Wang ◽  
Ping‐Tao Tseng ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Maintenance Treatment ◽  
Lithium Concentration ◽  
Meta Analysis ◽  
Recurrence Risk ◽  
Multicenter Cohort

Recurrence rates in stable bipolar disorder patients after drug discontinuation v. drug maintenance: a systematic review and meta-analysis

2020 ◽  
pp. 1-9
Author(s):  
Taro Kishi ◽  
Yuki Matsuda ◽  
Kenji Sakuma ◽  
Makoto Okuya ◽  
Kazuo Mishima ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Recurrence Rate ◽  
Meta Analysis ◽  
Mood Stabilizer ◽  
Recurrence Risk ◽  
Drug Discontinuation ◽  
Recurrence Rates ◽  
Double Blind ◽  
Mood Episode ◽  
Depressive Episodes

Abstract Background This random-effects model meta-analysis of double-blind, randomized placebo-controlled trials compared recurrence rates in bipolar disorder (BD) patients between antipsychotic/mood stabilizer discontinuation and maintenance groups. Methods We conducted systematic literature search of Embase, PubMed, and CENTRAL databases without language restriction from inception until 22 May 2020. Independent investigators assessed studies and extracted data. We calculated risk ratios (RRs) and numbers needed to benefit or harm (NNTB/NNTH). Primary outcome was the recurrence rate of any mood episode at 6 months. Secondary outcomes were recurrence rates of depressive episodes and manic/hypomanic/mixed episodes and all-cause discontinuation at 6 months. We also investigated these outcomes at 1, 3, 9, 12, 18, and 24 months. Results We identified 22 studies (n = 5462) receiving aripiprazole, asenapine, divalproex, long-acting injectable (LAI)-aripiprazole, LAI-risperidone, lamotrigine, lithium, olanzapine, paliperidone, or quetiapine. Mean study duration was 64.50 ± 69.35 weeks. The maintenance group demonstrated lower recurrence rates of any mood episode, depressive episodes, and manic/hypomanic/mixed episodes as well as reduced all-cause discontinuation at every observational point. The RRs (95% confidence interval, NNTB/NNTH) of recurrence rate at 6 months were 0.61 (0.54–0.70, 5) for any mood episode, 0.72 (0.60–0.87, 13) for depressive episodes, and 0.45 (0.36–0.57, 6) for manic/hypomanic/mixed episodes. The RR for all-cause discontinuation at 6 months was 0.71 (0.61–0.82, 6). Conclusions Maintaining drug treatment during clinically stable BD prevented recurrence for up to 24 months. Discontinuation of medications for ⩾1 month significantly increased recurrence risk. However, 47.3% of patients who discontinued drugs for 6 months did not experience recurrence.

Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: a systematic review and network meta-analysis

2014 ◽  
Vol 1 (5) ◽  
pp. 351-359 ◽  
Author(s):  
Tomofumi Miura ◽  
Hisashi Noma ◽  
Toshi A Furukawa ◽  
Hiroshi Mitsuyasu ◽  
Shiro Tanaka ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Maintenance Treatment ◽  
Meta Analysis ◽  
Pharmacological Treatments ◽  
Comparative Efficacy

An Adolescent with Bipolar Disorder Responding to a Lower Lithium Concentration at Maintenance Treatment

2009 ◽  
Vol 19 (1) ◽  
pp. 97-98
Author(s):  
Muslum Kul ◽  
Bahar Gokler ◽  
Sadriye Ebru Cengel Kultur
Keyword(s):  
Bipolar Disorder ◽  
Maintenance Treatment ◽  
Lithium Concentration

Common and Distinct Patterns of Intrinsic Brain Activity Alterations in Major Depression and Bipolar Disorder: Voxel-Based Meta-Analysis

2019 ◽  
Author(s):  
JiaYing Gong ◽  
Junjing Wang ◽  
Shaojuan Qiu ◽  
Pan Chen ◽  
Zhenye Luo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depression ◽  
Brain Activity ◽  
Meta Analysis ◽  
Intrinsic Brain Activity

Lamotrigine in the maintenance treatment of bipolar disorder: efficacy and acceptability

2001 ◽  
Author(s):  
KA Macritchie ◽  
JR Geddes ◽  
S Watson ◽  
AH Young
Keyword(s):  
Bipolar Disorder ◽  
Maintenance Treatment

scholarly journals Recurrence Rates in Stable Bipolar Disorder Patients after Drug Discontinuation versus Drug Maintenance: A Systematic Review and Meta-analysis – Corrigendum

2021 ◽  
pp. 1-1
Author(s):  
Taro Kishi ◽  
Yuki Matsuda ◽  
Kenji Sakuma ◽  
Makoto Okuya ◽  
Kazuo Mishima ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Meta Analysis ◽  
Drug Discontinuation ◽  
Recurrence Rates

P.331 Meta-analysis on tryptophan catabolites in bipolar disorder

2021 ◽  
Vol 44 ◽  
pp. S61-S62
Author(s):  
K. Hebbrecht ◽  
K. Skorobogatov ◽  
E. Giltay ◽  
M. Morrens
Keyword(s):  
Bipolar Disorder ◽  
Meta Analysis ◽  
Tryptophan Catabolites
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