scholarly journals A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine

2019 ◽  
Vol 25 (4) ◽  
Author(s):  
Christopher W. Tschumi ◽  
Anna W. Daszkowski ◽  
Amanda L. Sharpe ◽  
Marta Trzeciak ◽  
Michael J. Beckstead
Keyword(s):  
Locomotor Stimulation ◽  
Ethanol Drinking ◽  
History Of ◽  
Dopamine Transmission

scholarly journals Glyoxalase (GLO1) inhibition or genetic overexpression does not alter ethanol’s locomotor effects: implications for GLO1 as a therapeutic target in alcohol use disorders

2017 ◽  
Author(s):  
Amanda M Barkley-Levenson ◽  
Frances A Lagarda ◽  
Abraham A Palmer
Keyword(s):  
Dose Response ◽  
Response Curve ◽  
Partial Agonist ◽  
Positive Control ◽  
Dose Response Curve ◽  
Locomotor Response ◽  
Over Expression ◽  
Locomotor Stimulation ◽  
Ethanol Drinking ◽  
The Brain

AbstractBackgroundGlyoxalase 1 (GLO1) is an enzyme that metabolizes methylglyoxal (MG), which is a competitive partial agonist at GABAA receptors. Inhibition of GLO1 increases concentrations of MG in the brain and decreases binge-like ethanol drinking. The present study assessed whether inhibition of GLO1, or genetic over expression of Glo1, would also alter the locomotor effects of ethanol, which might explain reduced ethanol consumption following GLO1 inhibition. We used the prototypical GABAA receptor agonist muscimol as a positive control.MethodsMale C57BL/6J mice were pretreated with aeither the GLO1 inhibitor S-bromobenzylglutathione cyclopentyl diester (pBBG; 7.5 mg/kg; Experiment 1) or muscimol (0.75 mg/kg; Experiment 2), or their corresponding vehicle. We then determined whether locomotor response to a range of ethanol doses (0, 0.5, 1.0, 1.5, 2.0, and 2.5) was altered by either pBBG or muscimol pretreatment. We also examined the locomotor response to a range of ethanol doses in FVB/NJ wild type and transgenic Glo1 over expressing mice (Experiment 3). Anxiety-like behavior (time spent in the center of the open field) was assessed in all three experiments.ResultsThe ethanol dose-response curve was not altered by pretreatment with pBBG or by transgenic overexpression of Glo1. In contrast, muscimol blunted locomotor stimulation at low ethanol doses, and potentiated locomotor sedation at higher ethanol doses. No drug or genotype differences were seen in anxiety-like behavior after ethanol treatment.ConclusionsThe dose of pBBG used in this study is within the effective range shown previously to reduce ethanol drinking. Glo1 overexpression has been previously shown to increase ethanol drinking. However, neither manipulation altered the dose response curve for ethanol’s locomotor effects, whereas muscimol appeared to enhance the locomotor sedative effects of ethanol. The present data demonstrate that reduced ethanol drinking caused by GLO1 inhibition is not due to potentiation of ethanol’s stimulant or depressant effects.

scholarly journals OPERANT RESPONDING FOR ETHANOL IN RATS WITH A LONG-TERM HISTORY OF FREE-CHOICE ETHANOL DRINKING

1999 ◽  
Vol 34 (5) ◽  
pp. 685-689 ◽  
Author(s):  
E. Koros
Keyword(s):  
Free Choice ◽  
Operant Responding ◽  
Ethanol Drinking ◽  
History Of

Excessive Ethanol Drinking Following a History of Dependence Animal Model of Allostasis

2000 ◽  
Vol 22 (6) ◽  
pp. 581-594 ◽  
Author(s):  
A Roberts
Keyword(s):  
Animal Model ◽  
Ethanol Drinking ◽  
History Of

scholarly journals Effects of a single high dose of Chlorpyrifos in long-term feeding, ethanol consumption and ethanol preference in male Wistar rats with a previous history of continued ethanol drinking

2014 ◽  
Vol 39 (3) ◽  
pp. 425-435 ◽  
Author(s):  
Francisca Carvajal ◽  
Maria del Carmen Sanchez-Amate ◽  
Jos^|^eacute; Manuel Lerma-Cabrera ◽  
Inmaculada Cubero
Keyword(s):  
Wistar Rats ◽  
Previous History ◽  
Ethanol Consumption ◽  
High Dose ◽  
Ethanol Preference ◽  
Single High Dose ◽  
Ethanol Drinking ◽  
Male Wistar Rats ◽  
History Of

Effect of ethanol drinking, hangover, and exercise on adrenergic activity and heart rate variability in patients with a history of alcohol-induced atrial fibrillation

1998 ◽  
Vol 82 (3) ◽  
pp. 317-322 ◽  
Author(s):  
Tiina Mäki ◽  
Lauri Toivonen ◽  
Pekka Koskinen ◽  
Hannu Näveri ◽  
Matti Härkönen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Ethanol Drinking ◽  
Adrenergic Activity ◽  
History Of

scholarly journals Injury caused by alcoholic cardiomyopathy in spontaneous ethanol drinking rats

2021 ◽  
Author(s):  
Victória Mokarzel de Barros Camargo ◽  
Vanessa Caroline Fioravante ◽  
Patricia Fernanda Felipe Pinheiro ◽  
Francisco Eduardo Martinez
Keyword(s):  
Cardiac Tissue ◽  
Alcoholic Cardiomyopathy ◽  
Ethanol Drinking ◽  
Tissue Replacement ◽  
Ethanol Abuse ◽  
History Of ◽  
Ventricular Wall Thickness ◽  
Fiber Deposition ◽  
Acute Intake ◽  
Left Ventricle Myocardium

ABSTRACTWhen speaking of pathologies caused or aggravated by the constant ingestion of ethanol, people with liver and central nervous system diseases soon come to mind, however, the acute intake of large amounts of ethanol and chronic abuse induce toxic effects in the majority of tissues. The heart is highlighted, since alcoholic cardiomyopathy (AC) has prevalence among alcoholics of 23 to 40% and occurs more frequently in men than in women. AC is characterized by dilation and poor contraction of one or both ventricles in the presence of increased ventricular wall thickness, along with a long history of ethanol abuse and no other cause identified. Our aim is to quantify the rate of cardiac tissue replacement, collagen fiber deposition and pro inflammatory cytokines in the left ventricle myocardium of volunteer ethanol drinking rats.

scholarly journals Sexually divergent changes in select brain proteins and neurosteroid levels after a history of ethanol drinking and intermittent PTSD-like stress exposure in adult C57BL/6J mice

Alcohol ◽  
2020 ◽  
Vol 83 ◽  
pp. 115-125 ◽  
Author(s):  
Leslie L. Devaud ◽  
Mehrdad Alavi ◽  
Jeremiah P. Jensen ◽  
Melinda L. Helms ◽  
Michelle A. Nipper ◽  
...  
Keyword(s):  
Stress Exposure ◽  
Brain Proteins ◽  
Ethanol Drinking ◽  
History Of
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