scholarly journals Alcohol use disorder and divorce: evidence for a genetic correlation in a population-based Swedish sample

Addiction ◽  
2017 ◽  
Vol 112 (4) ◽  
pp. 586-593 ◽  
Author(s):  
Jessica E. Salvatore ◽  
Sara Larsson Lönn ◽  
Jan Sundquist ◽  
Paul Lichtenstein ◽  
Kristina Sundquist ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Genetic Correlation ◽  
Alcohol Use Disorder ◽  
Population Based ◽  
Swedish Sample

scholarly journals Different Characteristics and Heritabilities of Alcohol Use Disorder Classes: A Population-Based Swedish Study

2019 ◽  
Vol 54 (6) ◽  
pp. 647-655
Author(s):  
E C Long ◽  
H Ohlsson ◽  
J Sundquist ◽  
K Sundquist ◽  
K S Kendler
Keyword(s):  
Alcohol Use ◽  
Criminal Behavior ◽  
Alcohol Use Disorder ◽  
Latent Class ◽  
Environmental Influence ◽  
Low Frequency ◽  
Population Based ◽  
Outpatient Prescription ◽  
Class 1 ◽  
Swedish Sample

Abstract Aims The aims of the present study are to identify alcohol use disorder (AUD) classes among a population-based Swedish sample, determine if these classes differ by variables known to be associated with AUD and determine whether some AUD classes have stronger genetic influences than others. Methods A latent class analysis (LCA), based on types of registrations, was conducted on Swedish individuals with an AUD registration born between 1960 and 1990 (N = 184,770). These classes were then validated using demographics; patterns of comorbidity with drug abuse, psychiatric disorders and criminal behavior; and neighborhood-level factors, i.e. peer AUD and neighborhood deprivation. The degree of genetic and environmental influence was also investigated. Results The best-fit LCA had four classes: (a) outpatient/prescription, characterized by a mix of outpatient medical and prescription registrations, (b) low-frequency inpatient, characterized entirely by inpatient medical registrations, with the majority of individuals having one AUD registration, (c) high-frequency mixed, characterized by a mix of all four registration types, with the majority having four or more registrations and (d) crime, characterized almost entirely by criminal registrations. The highest heritability for both males and females was found for Class 3 (61% and 65%, respectively) and the lowest for Class 1 (20% for both), with shared environmental influences accounting for 10% or less of the variance in all Classes. Conclusions Using comprehensive, nationwide registry data, we showed evidence for four distinct, meaningful classes of AUD with varying degrees of heritability.

Sibling Alcohol Use Disorder Is Associated With Increased Risk for Suicide Attempt

2021 ◽  
pp. 216770262110250
Author(s):  
Mallory E. Stephenson ◽  
Sara Larsson Lönn ◽  
Jessica E. Salvatore ◽  
Jan Sundquist ◽  
Kenneth S. Kendler ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Suicide Attempt ◽  
Alcohol Use Disorder ◽  
Cox Regression ◽  
Population Based ◽  
Swedish Population ◽  
Sibling Pairs ◽  
Increased Risk ◽  
Using Data ◽  
Shared Genetic

The association between having a sibling diagnosed with alcohol use disorder (AUD) and risk for suicide attempt may be attributable to shared genetic liability between AUD and suicidal behavior, effects of environmental exposure to a sibling’s AUD, or both. To distinguish between these alternatives, we conducted a series of Cox regression models using data derived from Swedish population-based registers with national coverage. Among full sibling pairs (656,807 males and 607,096 females), we found that, even after we accounted for the proband’s AUD status, the proband’s risk for suicide attempt was significantly elevated when the proband’s sibling was affected by AUD. Furthermore, the proband’s risk for suicide attempt was consistently higher when the sibling’s AUD registration had occurred more recently. Our findings provide evidence for exposure to sibling AUD as an environmental risk factor for suicide attempt and suggest that clinical outreach may be warranted following a sibling’s diagnosis with AUD.

scholarly journals Divorce and the Onset of Alcohol Use Disorder: A Swedish Population-Based Longitudinal Cohort and Co-Relative Study

2017 ◽  
Vol 174 (5) ◽  
pp. 451-458 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Sara Larsson Lönn ◽  
Jessica Salvatore ◽  
Jan Sundquist ◽  
Kristina Sundquist
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Population Based ◽  
Swedish Population ◽  
Longitudinal Cohort

Roles of alcohol use disorder and resilience in risk of suicide attempt in men: A Swedish population‐based cohort

2022 ◽  
Author(s):  
Séverine Lannoy ◽  
Henrik Ohlsson ◽  
Jan Sundquist ◽  
Kristina Sundquist ◽  
Alexis C. Edwards
Keyword(s):  
Alcohol Use ◽  
Suicide Attempt ◽  
Alcohol Use Disorder ◽  
Population Based ◽  
Swedish Population

Patients with alcohol use disorder increase pain and analgesics use: A nationwide population-based cohort study

2021 ◽  
Vol 229 ◽  
pp. 109102
Author(s):  
Hao-Yuan Hung ◽  
Wu-Chien Chien ◽  
Chi-Hsiang Chung ◽  
Li-Ting Kao ◽  
Lok-Hi Chow ◽  
...  
Keyword(s):  
Cohort Study ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Population Based

Thiamine for preventing dementia development among patients with alcohol use disorder: A nationwide population-based cohort study

2019 ◽  
Vol 38 (3) ◽  
pp. 1269-1273 ◽  
Author(s):  
Wei-Po Chou ◽  
Yu-Han Chang ◽  
Hung-Chi Lin ◽  
Yi-Hsin Chang ◽  
Yun-Yu Chen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Population Based
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