scholarly journals Impact of opioid dose escalation on the development of substance use disorders, accidents, self‐inflicted injuries, opioid overdoses and alcohol and non‐opioid drug‐related overdoses: a retrospective cohort study

Addiction ◽  
2020 ◽  
Vol 115 (6) ◽  
pp. 1098-1112 ◽  
Author(s):  
Corey J. Hayes ◽  
Erin E. Krebs ◽  
Teresa Hudson ◽  
Joshua Brown ◽  
Chenghui Li ◽  
...  
Keyword(s):  
Substance Use ◽  
Cohort Study ◽  
Substance Use Disorders ◽  
Dose Escalation ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Opioid Dose

The Impact of Alcohol and Other Substance Use Disorders on Mortality in Patients With Eating Disorders: A Nationwide Register-Based Retrospective Cohort Study

2022 ◽  
Vol 179 (1) ◽  
pp. 46-57 ◽  
Author(s):  
Angelina Isabella Mellentin ◽  
Anna Mejldal ◽  
Maria Mercedes Guala ◽  
René Klinkby Støving ◽  
Lene Stryhn Eriksen ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Substance Use ◽  
Cohort Study ◽  
Substance Use Disorders ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
The Impact

The Impact of Alcohol and Other Substance Use Disorders on Mortality in Patients With Eating Disorders: A Nationwide Register-Based Retrospective Cohort Study

2021 ◽  
Author(s):  
Angelina Isabella Mellentin ◽  
Anna Mejldal ◽  
Maria Mercedes Guala ◽  
René Klinkby Støving ◽  
Lene Stryhn Eriksen ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Substance Use ◽  
Cohort Study ◽  
Substance Use Disorders ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
The Impact

The Impact Legal and Illegal Substance Use Disorders on Mortality in Patients With Eating Disorders: A Register-Based, Retrospective Cohort Study

2021 ◽  
Author(s):  
Angelina Isabella Mellentin ◽  
Anna Mejldal ◽  
Lene Stryhn ◽  
Maria Mercedes Guala ◽  
René Klinkby Støving ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Substance Use ◽  
Cohort Study ◽  
Substance Use Disorders ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
The Impact

scholarly journals Impact of Sexualized Substance Use and Other Risk Practices on HCV Microelimination in gbMSM Living with HIV: Urgent Need for Targeted Strategies. Results of a Retrospective Cohort Study

2021 ◽  
Author(s):  
María Martínez-Rebollar ◽  
Lorena De La Mora ◽  
Miriam Campistol ◽  
Bruno Cabrera ◽  
Albert Bagué ◽  
...  
Keyword(s):  
Substance Use ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Risk Practices ◽  
Living With Hiv

scholarly journals Treatment of chronic noncancer pain in patients on opioid therapy in primary care: A retrospective cohort study

2019 ◽  
Vol 153 (1) ◽  
pp. 52-58
Author(s):  
Arden R. Barry ◽  
Chantal E. Chris
Keyword(s):  
Primary Care ◽  
Cohort Study ◽  
Back Pain ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Opioid Therapy ◽  
Opioid Agonist ◽  
Chronic Noncancer Pain ◽  
Opioid Dose ◽  
Noncancer Pain

Background: This study sought to characterize the real-world treatment of chronic noncancer pain (CNCP) in patients on opioid therapy in primary care. Methods: A retrospective cohort study from 2014-18 was conducted at a multidisciplinary primary care clinic in Chilliwack, British Columbia. Included were adults on daily opioid therapy for CNCP. Patients receiving palliative care or ≤1 visit were excluded. Outcomes of interest included use of opioid/nonopioid pharmacotherapy, number/frequency of visits and proportion of patients able to reduce/discontinue opioid therapy. Results: Seventy patients (mean age 53 years, 53% male, 51% back pain) were included. Median follow-up was 6 visits over 12 months. Sixty-two patients (89%) reduced their opioid dose, 6 patients had no change and 2 patients required a dose increase. Mean opioid dose was reduced from 183 to 70 mg morphine equivalents daily. Twenty-four patients (34%) discontinued opioid therapy, 6 patients (9%) transitioned to opioid agonist therapy and 6 patients (9%) breached their opioid treatment agreement. Nonopioid pharmacotherapy included nonsteroidal anti-inflammatory drugs (64%), gabapentinoids (63%), tricyclic antidepressants (56%) and nabilone (51%). Discussion: Over half of patients were no longer on opioid therapy by the end of the study. Most patients had a disorder (e.g., back pain) for which opioids are generally not recommended. Overall mean opioid dose was reduced from baseline by approximately 60% over 1 year. Lack of access to specialized pain treatments may have accounted for high nonopioid pharmacotherapy usage. Conclusions: This study demonstrates that treatment of CNCP and opioid tapering can successfully be achieved in a primary care setting. Can Pharm J (Ott) 2020;153:xx-xx.

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