Subgroup analysis of East Asian patients in REGARD: A phase III trial of ramucirumab and best supportive care for advanced gastric cancer

2018 ◽  
Vol 14 (3) ◽  
pp. 204-209 ◽  
Author(s):  
Hyun Cheol Chung ◽  
Victor C. Kok ◽  
Rebecca Cheng ◽  
Yanzhi Hsu ◽  
Mauro Orlando ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Supportive Care ◽  
Advanced Gastric Cancer ◽  
Subgroup Analysis ◽  
East Asian ◽  
Best Supportive Care ◽  
Phase Iii ◽  
Phase Iii Trial ◽  
Asian Patients ◽  
East Asian Patients

Salvage Chemotherapy for Pretreated Gastric Cancer: A Randomized Phase III Trial Comparing Chemotherapy Plus Best Supportive Care With Best Supportive Care Alone

2012 ◽  
Vol 30 (13) ◽  
pp. 1513-1518 ◽  
Author(s):  
Jung Hun Kang ◽  
Soon Il Lee ◽  
Do Hyoung Lim ◽  
Keon-Woo Park ◽  
Sung Yong Oh ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Supportive Care ◽  
Group Performance ◽  
Eastern Cooperative Oncology Group ◽  
Best Supportive Care ◽  
Salvage Chemotherapy ◽  
Phase Iii ◽  
Phase Iii Trial ◽  
Prior Chemotherapy ◽  
Pretreated Patients

Purpose When designing this trial, there was no evidence that salvage chemotherapy (SLC) in advanced gastric cancer (AGC) resulted in substantial prolongation of survival when compared with best supportive care (BSC). However, SLC is often offered to pretreated patients with AGC for anecdotal reasons. Patients and Methods Patients with AGC with one or two prior chemotherapy regimens involving both fluoropyrimidines and platinum and with an Eastern Cooperative Oncology Group performance status (PS) 0 or 1 were randomly assigned in a ratio of 2:1 to SLC plus BSC or BSC alone. Choice of SLC—either docetaxel 60 mg/m2 every 3 weeks or irinotecan 150 mg/m2 every 2 weeks—was left to the discretion of investigators. Primary end point was overall survival (OS). Results Median OS was 5.3 months among 133 patients in the SLC arm and 3.8 months among 69 patients in the BSC arm (hazard ratio, 0.657; 95% CI, 0.485 to 0.891; one-sided P = .007). OS benefit for SLC was consistent in most of the prospectively defined subgroups, including age, PS, number of prior treatments, metastatic sites, hemoglobin levels, and response to prior chemotherapy. SLC was generally well tolerated, and adverse events were similar in the SLC and BSC arms. We found no median OS difference between docetaxel and irinotecan (5.2 v 6.5 months; P = .116). Conclusion To our knowledge, this is the largest phase III trial comparing SLC plus BSC with BSC alone in AGC. In pretreated patients, SLC is tolerated and significantly improves OS when added to BSC.

scholarly journals Comparison of FOLFOX and DOF regimens as first-line treatment in East Asian patients with advanced gastric cancer

2018 ◽  
Vol Volume 11 ◽  
pp. 375-381 ◽  
Author(s):  
Mengyao Liu ◽  
Guofang Hu ◽  
Yuan Wang ◽  
Jun Guo ◽  
Liyan Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
East Asian ◽  
Line Treatment ◽  
First Line ◽  
Asian Patients ◽  
First Line Treatment ◽  
East Asian Patients
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