east asian patients
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2022 ◽  
Vol 63 (1) ◽  
pp. 12
Author(s):  
Seong Joon Ahn ◽  
Lizhu Yang ◽  
Kazushige Tsunoda ◽  
Mineo Kondo ◽  
Yu Fujinami-Yokokawa ◽  
...  

2021 ◽  
Author(s):  
Jean Zhao ◽  
Sheng Zhong ◽  
Bo Wu ◽  
Frank Dubois ◽  
Shanshan Jiang ◽  
...  

Abstract While it is well known that Glioblastoma (GBM) shows profound inter- and intra-tumoral heterogeneity, disparities in molecular features across ancestry groups have been largely overlooked. We collected a large cohort of GBM samples from East Asian patients (EAS-GBM) and performed genomic and transcriptomic analyses of these samples (EAS-GBM, n=443). Further characterization and comparative analysis of the EAS-GBM with the predominantly European-ancestry TCGA GBM dataset (EUR-GBM, n=383) revealed differential genomic and genetic landscape and immunological profile of EAS-GBM from EUR-GBM. EAS-GBM showed an enrichment for NF1, H3F3A, TP53 and ATRX mutations compared to EUR-GBM. Transcriptomic clustering revealed distinct EAS-GBM specific subtypes, namely Proliferative (PL), Neuron-Synaptic (NS), Metabolic (MB) and Immunomodulatory (IM). Notably, the classic subtype of EUR-GBMs with EGFR as its main marker gene was absent in EAS-GBMs, Moreover, the IM subgroup in EAS-GBM with an expression profile that has been previously associated with response to immunotherapy in cancers. Together, our comprehensive characterization revealed the unique genomic and genetic features of EAS-GBMs, providing mechanistic rationale in patient stratification for molecular targeted therapy and drug development in the era of personalized medicine.


2021 ◽  
Author(s):  
Toshio Shimizu ◽  
Yasutoshi Kuboki ◽  
Chia-Chi Lin ◽  
Kan Yonemori ◽  
Tomoko Yanai ◽  
...  

2021 ◽  
Vol 16 (10) ◽  
pp. S1214
Author(s):  
B. Song ◽  
C. Xu ◽  
W. Wang ◽  
D. Wang ◽  
Y. Zhu ◽  
...  

2021 ◽  
Vol 21 ◽  
pp. S146-S147
Author(s):  
Kihyun Kim ◽  
Chang-Ki Min ◽  
Youngil Koh ◽  
Kenichi Ishizawa ◽  
Sung-Hyun Kim ◽  
...  

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