Risk factors for cytomegalovirus reactivation in autoimmune bullous disease patients on immunosuppressive therapy

2021 ◽  
Author(s):  
Yumi Aoyama ◽  
Seiko Sugiyama ◽  
Chieko Katayama ◽  
Koji Kamiya
Keyword(s):  
Risk Factors ◽  
Immunosuppressive Therapy ◽  
Cytomegalovirus Reactivation ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease

Risk factors for cytomegalovirus reactivation in patients with kidney disease under immunosuppressive therapy

2021 ◽  
Author(s):  
Yosuke Iwatani ◽  
Nobuyuki Amemiya ◽  
Hirohiko Nokiba ◽  
Mayuko Yamazaki ◽  
Hidekazu Sugiura ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Disease ◽  
Immunosuppressive Therapy ◽  
Cytomegalovirus Reactivation

scholarly journals Cytomegalovirus reactivation. Risk factors after allogeneic hematopoietic cell transplantation

2018 ◽  
Vol 73 ◽  
pp. 5
Author(s):  
F. Otermin ◽  
A. Cremona ◽  
P. Pessacq ◽  
S.J. Ramirez Borga ◽  
T. De luca ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Cytomegalovirus Reactivation

scholarly journals Reliability and validity of the Chinese version of the autoimmune bullous disease quality of life (ABQOL) questionnaire

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Baoqi Yang ◽  
Guo Chen ◽  
Qing Yang ◽  
Xiaoxiao Yan ◽  
Zhaoxia Zhang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Reliability And Validity ◽  
Chinese Version ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease

scholarly journals Assessing the Correlation Between Autoimmune Bullous Disease Quality of Life Questionnaires (ABQOL, TABQOL, DLQI) and Disease Severity Indices in Pemphigus and Bullous Pemphigoid

2020 ◽  
Author(s):  
Shan Cao ◽  
Lulu Sun ◽  
Zhongxiang Shi ◽  
Baoqi Yang ◽  
Furen Zhang
Keyword(s):  
Quality Of Life ◽  
Disease Severity ◽  
Bullous Pemphigoid ◽  
Strong Correlations ◽  
Disease Area ◽  
Area Index ◽  
Severity Of Disease ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease

Abstract Background: Pemphigus and bullous pemphigoid (BP) are autoimmune blistering diseases (AIBDs) that affect the skin and mucous membranes, and adversely impact quality of life (QOL). Few studies have assessed the correlation between the severity of disease and QOL in patients with pemphigus and BP. Objectives: To identify the correlation between the severity of AIBDs and QOL using the Autoimmune Bullous Disease Quality of Life (ABQOL), Treatment Autoimmune Bullous Disease Quality of Life (TABQOL), and Dermatology Life Quality Index (DLQI) questionnaires in Chinese patients with pemphigus and BP at baseline, and after 1, 3 and 6 months of treatment. Methods: Pemphigus and BP patients were invited to complete the ABQOL, TABQOL, and DLQI questionnaires. We measured the pemphigus disease area index (PDAI), autoimmune bullous skin disorder intensity score (ABSIS), and antibodies of desmoglein1,desmoglein3 (DSG1/DSG3) for pemphigus; and the bullous pemphigoid disease area index (BPDAI), ABSIS, and antibodies of BP180/ BP230 for BP as disease severity indices. The correlations between the severity of disease and QOL were analyzed by Spearman’s correlation coefficient (r). Results: Eighty-five patients were included: 55 with pemphigus and 30 with BP. The pemphigus subtypes included pemphigus vulgaris (PV, n = 32), pemphigus foliaceus (PF, n = 22), and paraneoplastic pemphigus (PNP, n = 1). We found significantly strong correlations between QOL (ABQOL, TABQOL, DLQI) and severity of disease (PDAI/BPDAI, ABSIS) with (r = 0.87, 0.77, 0.83; r = 0.86, 0.73, 0.80) for pemphigus and BP, respectively. Mild or strong correlations were also observed between QOL and antibody titers in pemphigus with DSG1/DSG3(r=0.32/0.36) and BP with BP180/BP230( r = 0.73/0.17) respectively. Conclusion: The QOL of patients with pemphigus and BP decreased with increased severity of the AIBDs. As the disease severity descended, so the QOL improved. The QOL indices should be used in clinical trials and to manage patients’ treatment, especially during the active disease stage, despite the mild correlation observed after 1 month of treatment.The PDAI to be better at assessing disease severity than the ABSIS in patients with pemphigus, and ABSIS are better than BPDAI in BP patients for correlation with the QOL indices.

scholarly journals The Incidence, Risk Factors, Predictors, and Prognoses of Cytomegalovirus Reactivation in Immunocompetent Mechanical Ventilation Patients: A Prospective Observational Study

2021 ◽  
Author(s):  
Zhihui Zhang ◽  
Xuesong Liu ◽  
Ling Sang ◽  
Sibei Chen ◽  
Zhan Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Area Under The Curve ◽  
University Hospital ◽  
Laboratory Findings ◽  
Cytomegalovirus Reactivation ◽  
Cmv Reactivation ◽  
Immunocompetent Patients

Abstract Background: Cytomegalovirus (CMV) reactivation can seriously affect the clinical prognoses of critically ill patients. However, the epidemiology and predictors of CMV in immunocompetent patients with mechanical ventilation are not very clear. Methods: A single-center, prospective observational study (conducted from June 30, 2017 to July 01, 2018) with a follow-up of 90 days (September 29, 2018) that included 71 CMV-seropositive immunocompetent patients with mechanical ventilation at a 37-bed university hospital general intensive care unit (ICU) in China. Routine detection of CMV DNAemia was performed once a week until 28 days (Day1, 7, 14, 21, 28) and serology, laboratory findings, and clinical data were obtained at admission.Results: Among 71 patients, 13 (18.3%) showed CMV reactivation within ICU 28-day admission. The median time to reactivation was 7 days. CMV reactivation was related to various factors, including body weight, body mass index (BMI), sepsis, NT-proBNP, BUN, and Hb levels (P< 0.05). In the multivariate regression model, BMI, Hb level, and sepsis were associated with CMV reactivation patients (P< 0.05). Moreover, the area under the curve (AUC) of BMI, Hb and BMI combined Hb was 0.69, 0.70, 0.76, respectively. The rate of complications, duration of mechanical ventilation, hospitalization expense, length of ICU stay, and 90-day all-cause mortality rate in patients with CMV reactivation was significantly higher than in those without CMV reactivation (P< 0.05).Conclusions: Among immunocompetent patients with mechanical ventilation, the incidence of CMV reactivation was high. CMV reactivation can lead to various adverse prognoses. BMI, Hb, and sepsis were independent risk factors for CMV reactivation. BMI and Hb may predict CMV reactivation.

scholarly journals Polyomavirus nephropathy: Risk analysis in paired renal Transplant recipients

2016 ◽  
Vol 19 (3) ◽  
pp. 6-9
Author(s):  
André Barros Albuquerque Esteves ◽  
Luiz Roberto Sousa Ulisses ◽  
Leonardo Figueiredo Camargo ◽  
Gabriel Giollo Rivelli ◽  
Marcos Vinicius de Sousa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplant ◽  
Acute Rejection ◽  
Immunosuppressive Therapy ◽  
Renal Transplant Recipients ◽  
Cold Ischemia Time ◽  
Hla Matching ◽  
Cold Ischemia ◽  
Ischemia Time ◽  
Related Risk

Polyomavirus allograft nephropathy (PVAN) has a negative impact on allograft function and survival. Analysis of paired kidneys from same donor can help to understand the role of recipient risk factors for PVAN. This analysis can also define donor related risk factors. Purpose: To identify recipient related risk factors for PVAN. Patients and Methods: Transversal cohort of 24 renal transplant patients in regular outpatient clinic follow up. Twelve patients with PVAN and their paired controls (recipients from same donor) without decoy cells in cytology were included in this analysis. Medical records were analyzed for demographic data, information of transplant and post-transplant data (acute rejection, renal function, immunosuppression). Results: Groups were comparable for initial immunosuppressive therapy based on basiliximab induction, tacrolimus, mycophenolate and steroids. Etiology of end-stage renal disease, race, age, HLA matching and delayed graft function considered as risk factors were also similar between patients with or without PVAN. However, PVAN group had more male patients (91.6 vs. 66.6%, PVAN versus control, p<0.05), higher incidence of biopsy proven acute rejection (41.6% vs. 8.3%, PVAN vs. control, p<0.05) and a trend to shorter cold ischemia time (15.6+6.2 versus 19.7+5.0, p=0.06). Conclusion: In this series, there were no significant differences in immunosuppressive therapy, age and HLA matching between patients with or without PVAN common risk factors. The only factors to be considered in this series were older age and a trend to shorter cold ischemia time in PVAN patients.

scholarly journals Poor Recognition of Risk Factors for Hepatitis B by Physicians Prescribing Immunosuppressive Therapy: A Call for Universal Rather than Risk-Based Screening

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0120749 ◽  
Author(s):  
Alissa Visram ◽  
Kelvin K. W. Chan ◽  
Phyllis McGee ◽  
Jordana Boro ◽  
Lisa K. Hicks ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis B ◽  
Immunosuppressive Therapy

Bacteremia in autoimmune bullous disease patients undergoing double-filtration plasmapheresis

2018 ◽  
Vol 30 (4) ◽  
pp. 402-404
Author(s):  
Chika Ohata ◽  
Hiroshi Koga ◽  
Hiroshi Saruta ◽  
Norito Ishii ◽  
Takekuni Nakama
Keyword(s):  
Double Filtration Plasmapheresis ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease ◽  
Double Filtration
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