scholarly journals Effect of the Anti-C1s Humanized Antibody TNT009 and Its Parental Mouse Variant TNT003 on HLA Antibody-Induced Complement Activation-A Preclinical In Vitro Study

2017 ◽  
Vol 17 (9) ◽  
pp. 2300-2311 ◽  
Author(s):  
M. Wahrmann ◽  
J. Mühlbacher ◽  
L. Marinova ◽  
H. Regele ◽  
N. Huttary ◽  
...  
Keyword(s):  
Complement Activation ◽  
In Vitro Study ◽  
Vitro Study ◽  
Humanized Antibody ◽  
Hla Antibody ◽  
Parental Mouse

Effect of Dialyzer Membranes on in Vitro Generation of Eicosanoids

1987 ◽  
Vol 10 (4) ◽  
pp. 275-278 ◽  
Author(s):  
G. Schultze ◽  
K. Wagner ◽  
H.-H. Neumayer ◽  
R. Fitzner ◽  
M. Molzahn
Keyword(s):  
Healthy Volunteers ◽  
Complement Activation ◽  
Blood Cells ◽  
In Vitro Study ◽  
Vitro Study ◽  
Prostaglandin E ◽  
Low Level ◽  
Fragment Formation ◽  
Foreign Materials

Eicosanoids are potent substances released from blood cells after contact with foreign materials. Eicosanoid generation, in addition to complement fragment formation, may be a valuable indicator of the biocompatibility of dialyzer membranes. In the present in vitro study, eicosanoid generation induced by several different flat dialyzer membranes [polyacrylonitrile (PAN), cuprammonium cellulose (CC), and polycarbonate (PC)] was evaluated and compared using blood from non-uremic healthy volunteers. Generation of prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) was greatest with PC followed by PAN and CC. The formation of C3a des arg with PAN was less than with either CC or PC. Our results suggest that dialyzer membranes affect complement activation and eicosanoid generation differently; biocompatibility as expressed by a low level of complement fragment formation does not necessarily translate into biocompatibility when considering eicosanoid generation.

In vitro study of the interaction between human gut microbiota and herbal extracts using willow bark extract as an example

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
EM Pferschy-Wenzig ◽  
K Koskinen ◽  
C Moissl-Eichinger ◽  
R Bauer
Keyword(s):  
Gut Microbiota ◽  
In Vitro Study ◽  
Vitro Study ◽  
Bark Extract ◽  
Herbal Extracts ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
Willow Bark

Evaluation of the Release Behavior of the Dexamethasone Embedded in Polycarbonate Polyurethane Membranes: An In Vitro Study

2003 ◽  
Vol 48 (1) ◽  
pp. 7 ◽  
Author(s):  
Dong Hyun Kim ◽  
Sung Gwon Kang ◽  
Sang Soo Park ◽  
Don Haeng Lee ◽  
Gyu Baek Lee ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Release Behavior ◽  
Polyurethane Membranes
Sign in / Sign up

Export Citation Format

Share Document