scholarly journals Vagus nerve stimulation dampens intestinal inflammation in a murine model of experimental food allergy

Allergy ◽  
2019 ◽  
Vol 74 (9) ◽  
pp. 1748-1759 ◽  
Author(s):  
Goele Bosmans ◽  
Iris Appeltans ◽  
Nathalie Stakenborg ◽  
Pedro J. Gomez‐Pinilla ◽  
Morgane V. Florens ◽  
...  
Keyword(s):  
Food Allergy ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Murine Model ◽  
Vagus Nerve Stimulation ◽  
Intestinal Inflammation

scholarly journals Microglia modulation through external vagus nerve stimulation in a murine model of Alzheimer's disease

2018 ◽  
Vol 146 (1) ◽  
pp. 76-85 ◽  
Author(s):  
Robert Kaczmarczyk ◽  
Dario Tejera ◽  
Bruce J. Simon ◽  
Michael T. Heneka
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Murine Model ◽  
Vagus Nerve Stimulation ◽  
Model Of Alzheimer’S Disease

scholarly journals Anti-inflammatory Effects of Abdominal Vagus Nerve Stimulation on Experimental Intestinal Inflammation

2019 ◽  
Vol 13 ◽  
Author(s):  
Sophie C. Payne ◽  
John B. Furness ◽  
Owen Burns ◽  
Alicia Sedo ◽  
Tomoko Hyakumura ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Intestinal Inflammation ◽  
Anti Inflammatory

scholarly journals 322 Vagus Nerve Stimulation Provides Prolonged and Spleen-Independent Protection Against Indomethacin-Induced Intestinal Inflammation

2013 ◽  
Vol 144 (5) ◽  
pp. S-67 ◽  
Author(s):  
Yaakov A. Levine ◽  
April Caravaca ◽  
Michael Faltys ◽  
Anthony Arnold ◽  
Ralph Zitnik
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Intestinal Inflammation

scholarly journals Effects of Vagus Nerve Stimulation in a Murine Model of Systemic Lupus Erythematosus

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Keisa W. Mathis ◽  
Harald Stauss ◽  
Grace S. Pham ◽  
Suhhyun S. Kim ◽  
Denis V. Kulp
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Murine Model ◽  
Lupus Erythematosus ◽  
Vagus Nerve Stimulation ◽  
Systemic Lupus

scholarly journals Vagus Nerve Stimulation Reduces Indomethacin-Induced Small Bowel Inflammation

2022 ◽  
Vol 15 ◽  
Author(s):  
April S. Caravaca ◽  
Yaakov A. Levine ◽  
Anna Drake ◽  
Michael Eberhardson ◽  
Peder S. Olofsson
Keyword(s):  
Small Bowel ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Neural Control ◽  
Intestinal Inflammation ◽  
Independent Effect ◽  
Lesion Area ◽  
Intestinal Lesion ◽  
Bowel Lesion

Crohn’s disease is a chronic, idiopathic condition characterized by intestinal inflammation and debilitating gastrointestinal symptomatology. Previous studies of inflammatory bowel disease (IBD), primarily in colitis, have shown reduced inflammation after electrical or pharmacological activation of the vagus nerve, but the scope and kinetics of this effect are incompletely understood. To investigate this, we studied the effect of electrical vagus nerve stimulation (VNS) in a rat model of indomethacin-induced small intestinal inflammation. 1 min of VNS significantly reduced small bowel total inflammatory lesion area [(mean ± SEM) sham: 124 ± 14 mm2, VNS: 62 ± 14 mm2, p = 0.002], intestinal peroxidation and chlorination rates, and intestinal and systemic pro-inflammatory cytokine levels as compared with sham-treated animals after 24 h following indomethacin administration. It was not known whether this observed reduction of inflammation after VNS in intestinal inflammation was mediated by direct innervation of the gut or if the signals are relayed through the spleen. To investigate this, we studied the VNS effect on the small bowel lesions of splenectomized rats and splenic nerve stimulation (SNS) in intact rats. We observed that VNS reduced small bowel inflammation also in splenectomized rats but SNS alone failed to significantly reduce small bowel lesion area. Interestingly, VNS significantly reduced small bowel lesion area for 48 h when indomethacin administration was delayed. Thus, 1 min of electrical activation of the vagus nerve reduced indomethacin-induced intestinal lesion area by a spleen-independent mechanism. The surprisingly long-lasting and spleen-independent effect of VNS on the intestinal response to indomethacin challenge has important implications on our understanding of neural control of intestinal inflammation and its potential translation to improved therapies for IBD.

Effect of Transcutaneous Vagus Nerve Stimulation in Dysphagia After Lateral Medullary Infarction: A Case Report

2019 ◽  
Vol 28 (4) ◽  
pp. 1381-1387
Author(s):  
Ying Yuan ◽  
Jie Wang ◽  
Dongyu Wu ◽  
Dahua Zhang ◽  
Weiqun Song
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Rating Scale ◽  
Tube Feeding ◽  
Nasogastric Feeding ◽  
Lateral Medullary Infarction ◽  
Severe Dysphagia ◽  
Transcutaneous Vagus Nerve Stimulation ◽  
Medullary Infarction

Purpose Severe dysphagia with weak pharyngeal peristalsis after dorsal lateral medullary infarction (LMI) requires long-term tube feeding. However, no study is currently available on therapeutic effectiveness in severe dysphagia caused by nuclear damage of vagus nerve after dorsal LMI. The purpose of the present investigation was to explore the potential of transcutaneous vagus nerve stimulation (tVNS) to improve severe dysphagia with weak pharyngeal peristalsis after dorsal LMI. Method We assessed the efficacy of 6-week tVNS in a 28-year-old woman presented with persisting severe dysphagia after dorsal LMI who had been on nasogastric feeding for 6 months. tVNS was applied for 20 min twice a day, 5 days a week, for 6 weeks. The outcome measures included saliva spitted, Swallow Function Scoring System, Functional Oral Intake Scale, Clinical Assessment of Dysphagia With Wallenberg Syndrome, Yale Pharyngeal Residue Severity Rating Scale, and upper esophagus X-ray examination. Results After tVNS, the patient was advanced to a full oral diet without head rotation or spitting. No saliva residue was found in the valleculae and pyriform sinuses. Contrast medium freely passed through the upper esophageal sphincter. Conclusion Our findings suggest that tVNS might provide a useful means for recovery of severe dysphagia with weak pharyngeal peristalsis after dorsal LMI. Supplemental Material https://doi.org/10.23641/asha.9755438

Vagus nerve stimulation in rheumatoid arthritis – Authors' reply

2021 ◽  
Vol 3 (1) ◽  
pp. e14-e15
Author(s):  
Mark C Genovese ◽  
Yaakov A Levine ◽  
David Chernoff
Keyword(s):  
Rheumatoid Arthritis ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation

Cognition-enhancing effect of vagus nerve stimulation on refractory epilepsy secondary to lissencephaly: A case report.

2018 ◽  
Vol 11 (1) ◽  
pp. 80-85
Author(s):  
Rodrigo Marmo da Costa e Souza ◽  
Felipe Ricardo Pereira Vasconcelos De Arruda ◽  
Jose Anderson Galdino Santos ◽  
Jamerson De Carvalho Andrade ◽  
Suellen Mary Marinho Dos Santos Andrade ◽  
...  
Keyword(s):  
Case Report ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Refractory Epilepsy ◽  
Enhancing Effect
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