scholarly journals Effects of Vagus Nerve Stimulation in a Murine Model of Systemic Lupus Erythematosus

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Keisa W. Mathis ◽  
Harald Stauss ◽  
Grace S. Pham ◽  
Suhhyun S. Kim ◽  
Denis V. Kulp
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Murine Model ◽  
Lupus Erythematosus ◽  
Vagus Nerve Stimulation ◽  
Systemic Lupus

scholarly journals Overview of therapeutic applications of non-invasive vagus nerve stimulation: a motivation for novel treatments for systemic lupus erythematosus

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Charrise M. Ramkissoon ◽  
Amparo Güemes ◽  
Josep Vehi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nervous System ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Lupus Erythematosus ◽  
Vagus Nerve Stimulation ◽  
Autoimmune Disorder ◽  
Systemic Lupus ◽  
Non Invasive ◽  
The Impact

AbstractSystemic lupus erythematosus (SLE) is a chronic systemic autoimmune disorder that commonly affects the skin, joints, kidneys, and central nervous system. Although great progress has been made over the years, patients still experience unfavorable secondary effects from medications, increased economic burden, and higher mortality rates compared to the general population. To alleviate these current problems, non-invasive, non-pharmacological interventions are being increasingly investigated. One such intervention is non-invasive vagus nerve stimulation, which promotes the upregulation of the cholinergic anti-inflammatory pathway that reduces the activation and production of pro-inflammatory cytokines and reactive oxygen species, culpable processes in autoimmune diseases such as SLE. This review first provides a background on the important contribution of the autonomic nervous system to the pathogenesis of SLE. The gross and structural anatomy of the vagus nerve and its contribution to the inflammatory response are described afterwards to provide a general understanding of the impact of stimulating the vagus nerve. Finally, an overview of current clinical applications of invasive and non-invasive vagus nerve stimulation for a variety of diseases, including those with similar symptoms to the ones in SLE, is presented and discussed. Overall, the review presents neuromodulation as a promising strategy to alleviate SLE symptoms and potentially reverse the disease.

Transcutaneous auricular vagus nerve stimulation reduces pain and fatigue in patients with systemic lupus erythematosus: a randomised, double-blind, sham-controlled pilot trial

2020 ◽  
pp. annrheumdis-2020-217872
Author(s):  
Cynthia Aranow ◽  
Yemil Atish-Fregoso ◽  
Martin Lesser ◽  
Meggan Mackay ◽  
Erik Anderson ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vagus Nerve ◽  
Musculoskeletal Pain ◽  
Nerve Stimulation ◽  
Lupus Erythematosus ◽  
Vagus Nerve Stimulation ◽  
Double Blind Study ◽  
Physician Global Assessment ◽  
Systemic Lupus ◽  
Double Blind

ObjectivesMusculoskeletal pain and fatigue are common features in systemic lupus erythematosus (SLE). The cholinergic anti-inflammatory pathway is a physiological mechanism diminishing inflammation, engaged by stimulating the vagus nerve. We evaluated the effects of non-invasive vagus nerve stimulation in patients with SLE and with musculoskeletal pain.Methods18 patients with SLE and with musculoskeletal pain ≥4 on a 10 cm Visual Analogue Scale were randomised (2:1) in this double-blind study to receive transcutaneous auricular vagus nerve stimulation (taVNS) or sham stimulation (SS) for 4 consecutive days. Evaluations at baseline, day 5 and day 12 included patient assessments of pain, disease activity (PtGA) and fatigue. Tender and swollen joint counts and the Physician Global Assessment (PGA) were completed by a physician blinded to the patient’s therapy. Potential biomarkers were evaluated.ResultstaVNS and SS were well tolerated. Subjects receiving taVNS had a significant decrease in pain and fatigue compared with SS and were more likely (OR=25, p=0.02) to experience a clinically significant reduction in pain. PtGA, joint counts and PGA also improved. Pain reduction and improvement of fatigue correlated with the cumulative current received. In general, responses were maintained through day 12. Plasma levels of substance P were significantly reduced at day 5 compared with baseline following taVNS but other neuropeptides, serum and whole blood-stimulated inflammatory mediators, and kynurenine metabolites showed no significant change at days 5 or 12 compared with baseline.ConclusiontaVNS resulted in significantly reduced pain, fatigue and joint scores in SLE. Additional studies evaluating this intervention and its mechanisms are warranted.

scholarly journals Microglia modulation through external vagus nerve stimulation in a murine model of Alzheimer's disease

2018 ◽  
Vol 146 (1) ◽  
pp. 76-85 ◽  
Author(s):  
Robert Kaczmarczyk ◽  
Dario Tejera ◽  
Bruce J. Simon ◽  
Michael T. Heneka
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Murine Model ◽  
Vagus Nerve Stimulation ◽  
Model Of Alzheimer’S Disease

The effect of OM-89 (SUBREUM®) on the murine model of systemic lupus erythematosus MRL-lpr/lpr

Lupus ◽  
1997 ◽  
Vol 6 (5) ◽  
pp. 436-440 ◽  
Author(s):  
YY Dhaher ◽  
MA Khamashta ◽  
B. Hartley ◽  
N. Taub ◽  
JC Farine ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Murine Model ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Vagus nerve stimulation dampens intestinal inflammation in a murine model of experimental food allergy

Allergy ◽  
2019 ◽  
Vol 74 (9) ◽  
pp. 1748-1759 ◽  
Author(s):  
Goele Bosmans ◽  
Iris Appeltans ◽  
Nathalie Stakenborg ◽  
Pedro J. Gomez‐Pinilla ◽  
Morgane V. Florens ◽  
...  
Keyword(s):  
Food Allergy ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Murine Model ◽  
Vagus Nerve Stimulation ◽  
Intestinal Inflammation

scholarly journals Suppression of autoreactive T and B lymphocytes by anti‐annexin A1 antibody in a humanized NSG murine model of systemic lupus erythematosus

2019 ◽  
Vol 199 (3) ◽  
pp. 278-293 ◽  
Author(s):  
N. Mihaylova ◽  
P. Chipinski ◽  
S. Bradyanova ◽  
T. Velikova ◽  
E. Ivanova‐Todorova ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Lymphocytes ◽  
Murine Model ◽  
Lupus Erythematosus ◽  
T And B Lymphocytes ◽  
Annexin A1 ◽  
Systemic Lupus
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