scholarly journals What we know and still ignore on COVID‐19 immune pathogenesis and a proposal based on experience of allergic disorders

Allergy ◽  
2021 ◽  
Author(s):  
Enrico Maggi ◽  
Bruno Giuseppe Azzarone ◽  
Giorgio Walter Canonica ◽  
Lorenzo Moretta
Keyword(s):  
Immune Pathogenesis ◽  
Allergic Disorders

scholarly journals Cytokines and their role in immune pathogenesis of allergy

2021 ◽  
Vol 5 (1) ◽  
pp. 32-37
Author(s):  
A.S. Simbirtsev ◽  
Keyword(s):  
Immune Response ◽  
Allergic Inflammation ◽  
Lymphoid Cells ◽  
T Helper Cell ◽  
Helper Cell ◽  
Immune Reactivity ◽  
T Helper ◽  
Immune Pathogenesis ◽  
Cell Clones ◽  
Allergic Disorders

Allergy is characterized by inadequate hyperimmune response to one or several antigens with the properties of allergens. A specific pattern of abnormal synthesis of some cytokines (principal molecular mediators of the initiation, development, and regulation of allergic inflammation) has an important pathogenic role in allergy. In recent years, it is generally accepted that allergic disorders are accounted for by impaired immune regulation resulting from increased imbalanced activation of allergen-specific T helper 2 cell clones. Allergic type of immune response is currently referred to as type 2 immune response which normally provides humoral immunity, anthelmintic protection etc. However, pathological response results in allergy. Studies on immune pathogenesis of allergic disorders have improved our understanding of the role of altered synthesis of some cytokines (key mediators of allergic inflammation). Cytokines involved in the initiation and regulation of allergy are produced by epithelial cells, various subsets of leukocytes, innate lymphoid cells, and allergen-activated T helper cell clones. Analysis of the associations of the changes in immune reactivity and clinical manifestations has established pathogenic heterogeneity and identified asthma phenotypes and endotypes. These findings have provided a basis for more reasonable, successful, and personalized approach to biological anti-cytokine treatment for allergic disorders. KEYWORDS: allergy, cytokines, T helper cell clones, phenotype, asthma, anti-cytokine therapy. FOR CITATION: Simbirtsev A.S. Cytokines and their role in immune pathogenesis of allergy. Russian Medical Inquiry. 2021;5(1):32–37. DOI: 10.32364/2587-6821-2021-5-1-32-37.

The Role of IFNγ in the Immune Pathogenesis of Primary Sclerosing Cholangitis

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
G Ravichandran ◽  
T Krech ◽  
G Tiegs ◽  
R Barikbin
Keyword(s):  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Immune Pathogenesis

Desloratadine and levocetirizine – the importance in allergic diseases treatment

2020 ◽  
Vol 13 (3) ◽  
pp. 336-342
Author(s):  
Rafał Pawliczak
Keyword(s):  
Allergic Diseases ◽  
Efficacy And Safety ◽  
H1 Receptor ◽  
Receptor Blockers ◽  
Allergic Disorders

H1-receptor blockers (including levocetirizine and desloratadine) are employed in treatment of multiple allergic diseases. In this review we deliver data regarding efficacy and safety these two drugs. Moreover, we are comparing their properties. The individualization therapy is a mainstay in allergic disorders treatment.

Optimal use of H1-receptor antagonists for allergic disorders

2002 ◽  
Vol 113 (9) ◽  
pp. vi-vii ◽  
Author(s):  
Leonard Bielory
Keyword(s):  
H1 Receptor ◽  
Receptor Antagonists ◽  
Allergic Disorders

Present Status of Immunotherapy (Desensitization) for Allergic Disorders

1979 ◽  
Vol 72 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Graham O. Solley
Keyword(s):  
Present Status ◽  
Allergic Disorders

Lymphocyte subsets in Bell's palsy: Immune pathogenesis and outcome prediction

2004 ◽  
Vol 31 (4) ◽  
pp. 258-260 ◽  
Author(s):  
Hasan Tekgul ◽  
Muzaffer Polat ◽  
Gul Serdaroglu ◽  
Tarkan Ikizoğlu ◽  
Mehmet Yalaz ◽  
...  
Keyword(s):  
Outcome Prediction ◽  
Lymphocyte Subsets ◽  
Bell’S Palsy ◽  
Bell's Palsy ◽  
Immune Pathogenesis

Prevalence of allergic disorders among the population in the city of Mashhad, Northeast Iran

2008 ◽  
Vol 17 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Abdol Reza Varasteh ◽  
Mohammad Fereidouni ◽  
Mohammad Taghi Shakeri ◽  
Fatemeh Vahedi ◽  
Ahmad Abolhasani ◽  
...  
Keyword(s):  
The City ◽  
Allergic Disorders ◽  
Northeast Iran

Secretory Phospholipases A2 as Multivalent Mediators of Inflammatory and Allergic Disorders

2003 ◽  
Vol 131 (3) ◽  
pp. 153-163 ◽  
Author(s):  
Francescopaolo Granata ◽  
Barbara Balestrieri ◽  
Angelica Petraroli ◽  
Giorgio Giannattasio ◽  
Gianni Marone ◽  
...  
Keyword(s):  
Allergic Disorders ◽  
Phospholipases A

Anti-IgE in the treatment of allergic disorders in pediatrics

2010 ◽  
Vol 22 (6) ◽  
pp. 758-764 ◽  
Author(s):  
Ari J Fried ◽  
Hans C Oettgen
Keyword(s):  
Allergic Disorders
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