Effect of platelet-derived growth factor-BB on gap junction and connexin43 in rat penile corpus cavernosum smooth muscle cells

Andrologia ◽  
2018 ◽  
Vol 51 (3) ◽  
pp. e13200 ◽  
Author(s):  
Fan Zhao ◽  
Junfeng Yan ◽  
Jianfeng Zhao ◽  
Bing Shi ◽  
Miaoyong Ye ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Gap Junction ◽  
Corpus Cavernosum ◽  
Muscle Cells ◽  
Platelet Derived Growth Factor

Rosuvastatin inhibits the apoptosis of platelet-derived growth factor-stimulated vascular smooth muscle cells by inhibiting p38 via autophagy

2021 ◽  
pp. JPET-AR-2021-000539
Author(s):  
Jun-Hwan Jo ◽  
Hyun-Soo Park ◽  
Do-Hyung Lee ◽  
Joo-Hui Han ◽  
Kyung-Sun Heo ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Platelet Derived Growth Factor

scholarly journals Secretion of a new growth factor, smooth muscle cell derived growth factor, distinct from platelet derived growth factor by cultured rabbit aortic smooth muscle cells

FEBS Letters ◽  
1988 ◽  
Vol 230 (1-2) ◽  
pp. 186-190 ◽  
Author(s):  
Nobuhiro Morisaki ◽  
Tetsuto Kanzaki ◽  
Tomoko Koshikawa ◽  
Yasushi Saito ◽  
Sho Yoshida
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Muscle Cells ◽  
Platelet Derived Growth Factor ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

Stimulation of Na-dependent phosphate transport by platelet-derived growth factor in rat aortic smooth muscle cells

2004 ◽  
Vol 174 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Ayako Kakita ◽  
Atsushi Suzuki ◽  
Keiko Nishiwaki ◽  
Yasunaga Ono ◽  
Motoko Kotake ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Phosphate Transport ◽  
Platelet Derived Growth Factor ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Stimulation Of

scholarly journals EXPRESS: Ubiquitin‑specific protease 7 mediates platelet derived growth factor-induced pulmonary arterial smooth muscle cells proliferation

2021 ◽  
pp. 204589402110461
Author(s):  
Yanting Zhu ◽  
Qianqian Zhang ◽  
Xin Yan ◽  
Lu Liu ◽  
Cui Zhai ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Platelet Derived Growth Factor ◽  
Specific Protease ◽  
Pulmonary Arterial ◽  
Arterial Smooth Muscle Cells ◽  
Pulmonary Arterial Smooth Muscle

Pulmonary arterial hypertension (PAH) is a devastating pulmonary vascular disease, in which the pathogenesis is complicated and unclear. Pulmonary arterial smooth muscle cells (PASMCs) proliferation is a key pathological feature of PAH. It has been shown that ubiquitin-specific protease 7 (USP7) is involved in cancer cell proliferation via deubiquitinating and stabilizing E3 ubiquitin ligase mouse double minute 2 (MDM2). However, the effect of USP7 and MDM2 on platelet derived growth factor (PDGF) -induced PASMCs proliferation is uncertain. This study aims to explore this issue. Our results indicated that PDGF up-regulated USP7 protein expression and stimulated PASMCs proliferation; this was accompanied with the increase of MDM2, forkhead box O4 (FoxO4) reduction and elevation of CyclinD1. While prior transfection of USP7 siRNA blocked PDGF-induced MDM2 up-regulation, FoxO4 down-regulation, increase of CyclinD1 and cell proliferation. Pre-depletion of MDM2 by siRNA transfection reversed PDGF-induced reduction of FoxO4, up-regulation of CyclinD1 and PASMCs proliferation. Furthermore, pre-treatment of cells with proteasome inhibitor MG-132 also abolished PDGF-induced FoxO4 reduction, CyclinD1 elevation and cell proliferation. Our study suggests that USP7 up-regulates MDM2, which facilitates FoxO4 ubiquitinated degradation, and subsequently increases the expression of CyclinD1 to mediate PDGF-induced PASMCs proliferation.

Binding of platelet derived growth factor (PDGF) isoforms on chinese hamster ovarian (CHO) K1 cells and human smooth muscle cells (hSMC)

2000 ◽  
Vol 151 (1) ◽  
pp. 33
Author(s):  
R.G Olivas ◽  
A Krettek ◽  
G Fager ◽  
F Lustig ◽  
M Reina ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Chinese Hamster ◽  
Muscle Cells ◽  
Platelet Derived Growth Factor ◽  
Pdgf Isoforms
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