Physiological role of reactive oxygen species in testis and epididymal spermatozoa

Andrologia ◽  
2022 ◽  
Author(s):  
Lizbeth Juárez‐Rojas ◽  
Fahiel Casillas ◽  
Alma López ◽  
Miguel Betancourt ◽  
Mohammad Mehdi Ommati ◽  
...  
2017 ◽  
Vol 131 (24) ◽  
pp. 2865-2883 ◽  
Author(s):  
Lawson Ung ◽  
Ushasree Pattamatta ◽  
Nicole Carnt ◽  
Jennifer L. Wilkinson-Berka ◽  
Gerald Liew ◽  
...  

For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging research has provided some evidence of the important physiological role of ROS in normal cell function, disease may arise where the concentration of ROS exceeds and overwhelms the body’s natural defence against them. Additionally, ROS may induce genomic aberrations which affect cellular homoeostasis and may result in disease. This literature review examines the current evidence for the role of oxidative stress in important ocular diseases with a view to identifying potential therapeutic targets for future study. The need is particularly pressing in developing treatments for conditions which remain notoriously difficult to treat, including glaucoma, diabetic retinopathy and age-related macular degeneration.


2015 ◽  
Vol 214 (3) ◽  
pp. 329-348 ◽  
Author(s):  
L. Zuo ◽  
T. Zhou ◽  
B. K. Pannell ◽  
A. C. Ziegler ◽  
T. M. Best

2011 ◽  
Vol 59 (12) ◽  
pp. 6583-6593 ◽  
Author(s):  
Daniel A. Jacobo-Velázquez ◽  
Ginés B. Martínez-Hernández ◽  
Silvia del C. Rodríguez ◽  
Cong-Mei Cao ◽  
Luis Cisneros-Zevallos

2017 ◽  
Vol 31 (9) ◽  
pp. 3729-3745 ◽  
Author(s):  
Jérôme Roy ◽  
Jean‐Marie Galano ◽  
Thierry Durand ◽  
Jean‐Yves Le Guennec ◽  
Jetty Chung‐Yung Lee

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