Unusual case of gallstones with chronic cholecystitis revealing a metachronous gallbladder metastasis from renal clear cell carcinoma

2019 ◽  
Vol 90 (4) ◽  
Author(s):  
Fei Liu ◽  
Fu‐Yu Li ◽  
Rong‐Xing Zhou
Keyword(s):  
Cell Carcinoma ◽  
Unusual Case ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Chronic Cholecystitis ◽  
Gallbladder Metastasis

scholarly journals An unusual case of metastatic renal clear cell carcinoma presented as a solitary subcutaneous mass invading the manubrium

QJM ◽  
2014 ◽  
Vol 108 (2) ◽  
pp. 161-162
Author(s):  
J.S. Li ◽  
C.K. Zhou ◽  
C.H. Yi ◽  
W.D. Zhang ◽  
L. Li
Keyword(s):  
Cell Carcinoma ◽  
Unusual Case ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Subcutaneous Mass

scholarly journals Gallbladder metastasis of renal clear cell carcinoma 15 years after primary cancer excision: a case report

2018 ◽  
Vol 12 (1) ◽  
Author(s):  
Yasufumi Saito ◽  
Hiroshi Okuda ◽  
Makoto Yoshida ◽  
Seiji Okimasa ◽  
Toshikatsu Fukuda ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Primary Cancer ◽  
Gallbladder Metastasis

Delayed Pancreatic Metastasis of Renal Clear Cell Carcinoma

2013 ◽  
Vol 13 (2) ◽  
pp. 79-80
Author(s):  
Zane Simtniece ◽  
Gatis Kirsakmens ◽  
Ilze Strumfa ◽  
Andrejs Vanags ◽  
Maris Pavars ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Surgical Treatment ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Primary Tumour ◽  
Renal Clear Cell Carcinoma ◽  
Pancreatic Metastasis ◽  
Distal Pancreatic Resection

Abstract Here, we report surgical treatment of a patient presenting with pancreatic metastasis (MTS) of renal clear cell carcinoma (RCC) 11 years after nephrectomy. RCC is one of few cancers that metastasise in pancreas. Jaundice, abdominal pain or gastrointestinal bleeding can develop; however, asymptomatic MTS can be discovered by follow-up after removal of the primary tumour. The patient, 67-year-old female was radiologically diagnosed with a clinically silent mass in the pancreatic body and underwent distal pancreatic resection. The postoperative period was smooth. Four months after the surgery, there were no signs of disease progression.

Parotid metastasis of renal clear cell carcinoma: a case report

2009 ◽  
Vol 28 (10) ◽  
pp. 1271-1272
Author(s):  
Xiao-mei MA ◽  
Hui-min LIU
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma

Protein interactions of cortactin in relation to invadopodia formation in metastatic renal clear cell carcinoma

Tumor Biology ◽  
2014 ◽  
Vol 36 (5) ◽  
pp. 3417-3422 ◽  
Author(s):  
Hong-Liang Shen ◽  
Qing-Jun Liu ◽  
Pei-Qian Yang ◽  
Ye Tian
Keyword(s):  
Cell Carcinoma ◽  
Protein Interactions ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Invadopodia Formation

scholarly journals LncRNA CDKN2B-AS1 stabilized by IGF2BP3 drives the malignancy of renal clear cell carcinoma through epigenetically activating NUF2 transcription

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Xina Xie ◽  
Jiatian Lin ◽  
Xiaoqin Fan ◽  
Yuantang Zhong ◽  
Yequn Chen ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Survival Data ◽  
Kinase Inhibitor ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Binding Protein ◽  
Renal Clear Cell Carcinoma ◽  
Receiver Operating Curve ◽  
Migration And Invasion ◽  
Integrated Analysis

AbstractBecause of the lack of sensitivity to radiotherapy and chemotherapy, therapeutic options for renal clear cell carcinoma (KIRC) are scarce. Long noncoding RNAs (lncRNAs) play crucial roles in the progression of cancer. However, their functional roles and upstream mechanisms in KIRC remain largely unknown. Exploring the functions of potential essential lncRNAs may lead to the discovery of novel targets for the diagnosis and treatment of KIRC. Here, according to the integrated analysis of RNA sequencing and survival data in TCGA-KIRC datasets, cyclin-dependent kinase inhibitor 2B antisense lncRNA (CDKN2B-AS1) was discovered to be the most upregulated among the 14 lncRNAs that were significantly overexpressed in KIRC and related to shorter survival. Functionally, CDKN2B-AS1 depletion suppressed cell proliferation, migration, and invasion both in vitro and in vivo. Mechanistically, CDKN2B-AS1 exerted its oncogenic activity by recruiting the CREB-binding protein and SET and MYND domain-containing 3 epigenetic-modifying complex to the promoter region of Ndc80 kinetochore complex component (NUF2), where it epigenetically activated NUF2 transcription by augmenting local H3K27ac and H3K4me3 modifications. Moreover, we also showed that CDKN2B-AS1 interacted with and was stabilized by insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an oncofetal protein showing increased levels in KIRC. The Kaplan–Meier method and receiver operating curve analysis revealed that patients whose IGF2BP3, CDKN2B-AS1 and NUF2 are all elevated showed the shortest survival time, and the combined panel (containing IGF2BP3, CDKN2B-AS1, and NUF2) possessed the highest accuracy in discriminating high-risk from low-risk KIRC patients. Thus, we conclude that the stabilization of CDKN2B-AS1 by IGF2BP3 drives the malignancy of KIRC through epigenetically activating NUF2 transcription and that the IGF2BP3/CDKN2B-AS1/NUF2 axis may be an ideal prognostic and diagnostic biomarker and therapeutic target for KIRC.

scholarly journals A microRNA‐clinical prognosis model to predict the overall survival for kidney renal clear cell carcinoma

2021 ◽  
Author(s):  
Yating Zhan ◽  
Rongrong Zhang ◽  
Chunxue Li ◽  
Xuantong Xu ◽  
Kai Zhu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Clinical Prognosis ◽  
Prognosis Model
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