scholarly journals Serotonin homeostasis in the materno‐foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO‐A) in uptake and degradation of serotonin by human and rat term placenta

2020 ◽  
Vol 229 (4) ◽  
Author(s):  
Rona Karahoda ◽  
Hana Horackova ◽  
Petr Kastner ◽  
Andreas Matthios ◽  
Lukas Cerveny ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase A ◽  
Term Placenta ◽  
Mao A

scholarly journals Role of Monoamine Oxidase A (MAO-A) in Cardiac Aging

2020 ◽  
Vol 4 (2) ◽  
pp. 31-40
Author(s):  
Chandreyee Datta ◽  
Ashish Bhattacharjee
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase A ◽  
Cardiac Aging ◽  
Mao A

scholarly journals NMDARs Mediate the Role of Monoamine Oxidase A in Pathological Aggression

2012 ◽  
Vol 32 (25) ◽  
pp. 8574-8582 ◽  
Author(s):  
M. Bortolato ◽  
S. C. Godar ◽  
M. Melis ◽  
A. Soggiu ◽  
P. Roncada ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase A

scholarly journals Genetic Susceptibility for Individual Cooperation Preferences: The Role of Monoamine Oxidase A Gene (MAOA) in the Voluntary Provision of Public Goods

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20959 ◽  
Author(s):  
Vanessa Mertins ◽  
Andrea B. Schote ◽  
Wolfgang Hoffeld ◽  
Michele Griessmair ◽  
Jobst Meyer
Keyword(s):  
Monoamine Oxidase ◽  
Public Goods ◽  
Genetic Susceptibility ◽  
Monoamine Oxidase A ◽  
Voluntary Provision

The role of microsomal oxidation in the regulation of monoamine oxidase -A activity at the brain in the restrain stress paradigm rats

2019 ◽  
Vol 100 ◽  
pp. S34
Author(s):  
Vadim Tseylikman ◽  
Olga Tseylikman ◽  
Eugenia Manukhina ◽  
H. Fred Downey
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase A ◽  
Microsomal Oxidation ◽  
The Brain

Are Coumarin Derivatives The New Keys in Depression Treatment? In silico Key-lock Fitting Analysis of Coumarin Derivatives with Monoamine Oxidase-A

2020 ◽  
Vol 7 ◽  
Author(s):  
Dilara Karaman ◽  
Kemal YELEKCI ◽  
Serkan ALTUNTAS
Keyword(s):  
Monoamine Oxidase ◽  
Protein Interactions ◽  
In Silico ◽  
Monoamine Oxidase A ◽  
Coumarin Derivatives ◽  
Discovery Studio ◽  
Mao B ◽  
Drug Candidates ◽  
Mao A ◽  
Molecular Modeling Studies

The research of ligand-protein interactions with in silico molecular modeling studies on the atomic level gives an opportunity to be understood the pharmacokinetic metabolism of anti-depressant drug candidates. Monoamine oxidase (MAO) enzymes are important targets for the treatment of depressive disorder. MAOs have two isoforms as MAO-A and MAO-B being responsible for catalyzing of neurological amines. In this study a new series of coumarin derivatives were designed for selective and reversible inhibition of MAO-A enzyme. 3rd, 5th and 7th positions were selected to be placed of five different side groups. Docking procedures of each ligand in M series of these novel 125 compounds were executed with 10 runs by using AutoDock4.2 software. Docking results were analyzed via Discovery Studio 3.1 (Biovia Inc.). The most promising compounds were M118 and M123 according to selectivity index, SI (MAO-B/MAO-A)=180 fold and 209 fold and Ki values 7.25 nM and 12.01 nM, respectively. Overall, the current study provided significant knowledge for the development of new anti-depressant drugs.

Polymorphisms of the serotonin transporter and Monoamine Oxidase A gene in patients with metastatic midgut carcinoid tumors

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 4557-4557
Author(s):  
A. van der Horst-Schrivers ◽  
E. de Vries ◽  
P. Willemse ◽  
I. Kema ◽  
T. Links ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Serotonin Transporter ◽  
Promoter Region ◽  
Carcinoid Tumors ◽  
Monoamine Oxidase A ◽  
Independent Effect ◽  
Clinical Effects ◽  
Cox Regression Analysis ◽  
Midgut Carcinoid ◽  
Mao A

4557 Background: In patients with metastatic midgut carcinoid tumors increased serotonin secretion is related to the carcinoid syndrome and mortality. Free serotonin is taken up via the serotonin transporter (5-HTT) in the liver and the lung and metabolized to 5- hydroxyindolacetic acid (5-HIAA) by Monoamine Oxidase A (MAO-A). The 5-HTT gene has a functional polymorphism in the promoter region (5-HTTPLR), with a short (S, less active) and long (L) allele and a polymorphic region in the second intron with variable number tandem repeats (VNTR-2). The MAO-A gene contains a length polymorphism in its promoter region (MAOA-LPR). To determine the clinical effects of the serotonin metabolizing capacity of individual patients, the association between different genotypes and symptoms (flushes and diarrhea) and survival was studied. Methods: 107 patients with metastatic midgut carcinoid tumors were genotyped for 5-HTTPLR, VNTR-2 and MAO-A-LPR. Differences were tested using Chi-square test and survival according to genotypes was analyzed using Kaplan Meier survival curves and tested with a log rank test. The independent effect of genotypes on survival was studied with multivariate Cox regression analysis with adjustments for the urinary 5-HIAA level, age at presentation and the presence of liver metastases. Results: The various genotypic variants were not related to flushes or diarrhea. Patients with the SS variant of 5-HTTLPR had a shorter median survival (45 months, 95% Confidence Interval (CI) 0.50–90) compared to patients with the LS (113 months, 95% CI 53–172) and the LL variant (90 months, 95% CI 64–115) (P=0.02). After adjustment, survival in patients with the SS variant remained worse with an odds ratio of 0.43 (95% CI 0.23–0.83; P=0.009) and 0.63 (95% CI 0.33–1.11; P=0.1) compared to patients with the LS and the LL variant respectively. Survival was not influenced by the VNTR-2 or MAOA-LPR. Conclusions: The SS genotype of the 5-HTTLPR is independently associated with a worse survival in patients with metastatic midgut carcinoid tumors. No significant financial relationships to disclose.

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