Synergistic antitumor effect of combining metronomic chemotherapy with adoptive cell immunotherapy in nude mice

Apmis ◽  
2014 ◽  
Vol 122 (5) ◽  
pp. 380-391 ◽  
Author(s):  
Shujing Shi ◽  
Leilei Tao ◽  
Haizhu Song ◽  
Longbang Chen ◽  
Guichun Huang
Keyword(s):  
Nude Mice ◽  
Antitumor Effect ◽  
Metronomic Chemotherapy ◽  
Synergistic Antitumor Effect ◽  
Cell Immunotherapy ◽  
Adoptive Cell Immunotherapy

scholarly journals Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice

Neoplasma ◽  
2016 ◽  
Author(s):  
L. LIU ◽  
S. QIU ◽  
Y. LIU ◽  
Z. LIU ◽  
Y. ZHENG ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Nude Mice ◽  
Antitumor Effect ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Synergistic Antitumor Effect

Synergistic antitumor effect of ING4/PTEN double tumor suppressors mediated by adenovirus modified with arginine-glycine-aspartate on glioma

2020 ◽  
Vol 64 (2) ◽  
Author(s):  
Yaodong Zhao ◽  
Jiarong Wang ◽  
Jicheng Yang ◽  
Jingcheng Miao
Keyword(s):  
Tumor Suppressors ◽  
Antitumor Effect ◽  
Synergistic Antitumor Effect

scholarly journals Antitumor effect of IL-12 gene-modified bone marrow mesenchymal stem cells combined with Fuzheng Yiliu decoction in an in vivo glioma nude mouse model

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jianjun Wu ◽  
Shoupin Xie ◽  
Hailong Li ◽  
Yanxia Zhang ◽  
Jia Yue ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Treatment Group ◽  
Nude Mice ◽  
Antitumor Effect ◽  
Tumor Tissue ◽  
Model Group ◽  
Nude Mouse Model ◽  
Marrow Mesenchymal Stem Cells

Abstract Background Glioma is a complex cancer with a high morbidity and high mortality. Bone marrow mesenchymal stem cells (BMSCs) have shown promise as an excellent cell/drug delivery vehicle for gene-targeted therapy; however, maintaining genetic stability and biological activity remains difficult. Furthermore, whether BMSCs support or inhibit tumor growth remains debated. This study investigated whether a traditional Chinese medicine fomular, Fuzheng Yiliu decoction (FYD) had a synergistic antitumor effect with IL-12 gene-modified BMSCs in glioma-bearing nude mice Methods The lentivirus-mediated IL-12 gene was transfected into primarily cultured BMSCs. A total of 72 BALB/c nude mice were used to establish xenograft models with glioma U251 cells and were divided into groups (n = 12) including blank control group, nude mouse model group (model group), lentiviral transfection of BMSC group with no gene loading (BMSC group), IL-12 lentivirus-transfected BMSC group (IL-12 + BMSC group), FYD treatment group (FYD group), and FYD treatment in IL-12 lentivirus-transfected BMSC group (FYD + IL-12 + BMSC group).. After treatment for 14 days, all mice were sacrificed to collect tumor tissue and serum for more detection, such as distribution of BMSCs, cell apoptosis in xenograft tumors, serum IL-12 and INF-γ levels, mouse weight and tumor volume were measured Results There were significantly more apoptotic cells in tumor tissue in IL-12 gene transfected group, FYD treatment group and FYD combining with IL-12 gene transfected group than that in the model group (P < 0.05). The FYD + IL-12 + BMSC group showed significantly higher Bax and lower Bcl-2 expression (P < 0.05), and serum IL-12 and INF-γ levels (P < 0.05) were higher than that in all other groups. After the intervention, this group also showed a strong inhibitory effect against tumor growth (P < 0.05) Conclusions This study suggested FYD treatment combined with IL-12 gene-modified BMSCs shows synergistic antitumor effect in glioma-bearing nude mice.

Transcutaneous Tumor Vaccination Combined With aPD-1 Treatment Produces a Synergistic Antitumor Effect

2021 ◽  
Author(s):  
Xinran Song ◽  
Huoyan Hong ◽  
Gomaa El Fawal ◽  
Jinglei Wu ◽  
Di Jiang ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Tumor Vaccination ◽  
Synergistic Antitumor Effect

scholarly journals Synergistic antitumor effect of brusatol combined with cisplatin on colorectal cancer cells

2018 ◽  
Author(s):  
Hai‑Ming Chen ◽  
Zheng‑Quan Lai ◽  
Hui‑Jun Liao ◽  
Jian‑Hui Xie ◽  
Yan‑Fang Xian ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Synergistic Antitumor Effect ◽  
Colorectal Cancer Cells

Natural killer cells as a double-edged sword in cancer immunotherapy: A comprehensive review from cytokine therapy to adoptive cell immunotherapy

2020 ◽  
Vol 155 ◽  
pp. 104691 ◽  
Author(s):  
Yuanlin Wu ◽  
Jing Li ◽  
Parham Jabbarzadeh Kaboli ◽  
Jing Shen ◽  
Xu Wu ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Cancer Immunotherapy ◽  
Natural Killer ◽  
Cytokine Therapy ◽  
Killer Cells ◽  
Comprehensive Review ◽  
Cell Immunotherapy ◽  
Adoptive Cell Immunotherapy

Interferon-alpha 2a up-regulated thymidine phosphorylase and enhanced antitumor effect of capecitabine on hepatocellular carcinoma in nude mice

2004 ◽  
Vol 130 (9) ◽  
Author(s):  
Yong-Sheng Xiao ◽  
Zhao-You Tang ◽  
Jia Fan ◽  
Jian Zhou ◽  
Zhi-Quan Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Interferon Alpha ◽  
Nude Mice ◽  
Thymidine Phosphorylase ◽  
Antitumor Effect

Membrane Loaded Copper Oleate PEGylated Liposome Combined with Disulfiram for Improving Synergistic Antitumor Effect In Vivo

2018 ◽  
Vol 35 (7) ◽  
Author(s):  
Lingli Zhou ◽  
Liu Yang ◽  
Chulei Yang ◽  
Yi Liu ◽  
Qiuyue Chen ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Pegylated Liposome ◽  
Synergistic Antitumor Effect ◽  
Copper Oleate

931 Synergistic antitumor effect of satraplatin and NVP-BEZ235 in cisplatin-resistant human bladder cancer cells

2016 ◽  
Vol 15 (3) ◽  
pp. e931
Author(s):  
C.Y. Yoon ◽  
M.K. Kong ◽  
H.G. Ahn ◽  
S.G. Kang ◽  
J.H. Han ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Synergistic Antitumor Effect ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells
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