Anti-TNF treatment in Crohn's disease and risk of bowel resection-a population based cohort study

2017 ◽  
Vol 46 (6) ◽  
pp. 589-598 ◽  
Author(s):  
M. Eberhardson ◽  
J. K. Söderling ◽  
M. Neovius ◽  
T. Cars ◽  
P. Myrelid ◽  
...  
Keyword(s):  
Cohort Study ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bowel Resection ◽  
Population Based

79 Disease Behavior in Crohn's Disease Patients Diagnosed in the Biological Era - A Dutch Population-Based IBD-SL Cohort Study

2015 ◽  
Vol 148 (4) ◽  
pp. S-22-S-23 ◽  
Author(s):  
Steven Jeuring ◽  
Tim Van den Heuvel ◽  
Maurice Zeegers ◽  
Wim Hameeteman ◽  
Mariëlle Romberg-Camps ◽  
...  
Keyword(s):  
Cohort Study ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Population Based ◽  
Dutch Population ◽  
Disease Behavior

scholarly journals Temporal Trends in Surgical Resection Rates and Biologic Prescribing in Crohn’s Disease: A Population-based Cohort Study

2020 ◽  
Vol 14 (9) ◽  
pp. 1241-1247
Author(s):  
P W Jenkinson ◽  
N Plevris ◽  
S Siakavellas ◽  
M Lyons ◽  
I D Arnott ◽  
...  
Keyword(s):  
Cohort Study ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Biologic Therapy ◽  
Temporal Trends ◽  
Cumulative Risk ◽  
Population Based ◽  
Cumulative Probability ◽  
Cox Regression Analysis ◽  
Over Time

Abstract Background The use of biologic therapy for Crohn’s disease [CD] continues to evolve, however, the effect of this on the requirement for surgery remains unclear. We assessed changes in biologic prescription and surgery over time in a population-based cohort. Methods We performed a retrospective cohort study of all 1753 patients diagnosed with CD in Lothian, Scotland, between January 1, 2000 and December 31, 2017, reviewing the electronic health record of each patient to identify all CD-related surgery and biologic prescription. Cumulative probability and hazard ratios for surgery and biologic prescription from diagnosis were calculated and compared using the log-rank test and Cox regression analysis stratified by year of diagnosis into cohorts. Results The 5-year cumulative risk of surgery was 20.4% in cohort 1 [2000–2004],18.3% in cohort 2 [2005–2008], 14.7% in cohort 3 [2009–2013], and 13.0% in cohort 4 [2014–2017] p <0.001. The 5-year cumulative risk of biologic prescription was 5.7% in cohort 1, 12.2% in cohort 2, 22.0% in cohort 3, and 44.9% in cohort 4 p <0.001. Conclusions The increased and earlier use of biologic therapy in CD patients corresponded with a decreasing requirement for surgery over time within our cohort. This could mean that adopting a top-down or accelerated step-up treatment strategy may be effective at reducing the requirement for surgery in newly diagnosed CD.

scholarly journals P821 Incidence of paediatric stricturing duodenal Crohn’s disease in South-East Scotland: A 12-year population-based cohort study

2018 ◽  
Vol 12 (supplement_1) ◽  
pp. S531-S531
Author(s):  
C Burgess ◽  
P Gillett ◽  
D Mitchell ◽  
P Hammond ◽  
P Henderson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Population Based

Natural History of Pediatric Crohn's Disease: A Population-Based Cohort Study

2008 ◽  
Vol 135 (4) ◽  
pp. 1106-1113 ◽  
Author(s):  
Gwenola Vernier–Massouille ◽  
Mamadou Balde ◽  
Julia Salleron ◽  
Dominique Turck ◽  
Jean Louis Dupas ◽  
...  
Keyword(s):  
Cohort Study ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Natural History ◽  
Population Based ◽  
History Of

Colorectal cancer in Crohn's disease: a Scandinavian population-based cohort study

2020 ◽  
Vol 5 (5) ◽  
pp. 475-484 ◽  
Author(s):  
Ola Olén ◽  
Rune Erichsen ◽  
Michael C Sachs ◽  
Lars Pedersen ◽  
Jonas Halfvarson ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Population Based
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