scholarly journals Haplotype structure defines effects of common DPYD variants c.85T>C (rs1801265) and c.496A>G (rs2297595) on DPD activity: implication for 5‐fluorouracil toxicity

2021 ◽  
Author(s):  
Seid Hamzic ◽  
Dominic Schärer ◽  
Steven Offer ◽  
Didier Meulendijks ◽  
Christos Nakas ◽  
...  
Keyword(s):  
Haplotype Structure ◽  
Fluorouracil Toxicity

Corticosteroids and fluorouracil toxicity

1966 ◽  
Vol 117 (6) ◽  
pp. 775-777 ◽  
Author(s):  
J. Horton
Keyword(s):  
Fluorouracil Toxicity

scholarly journals Evidence for Selection at the fused1 Locus of Drosophila americana

Genetics ◽  
2001 ◽  
Vol 158 (1) ◽  
pp. 279-290 ◽  
Author(s):  
Jorge Vieira ◽  
Bryant F McAllister ◽  
Brian Charlesworth
Keyword(s):  
Amino Acid ◽  
Sequence Variation ◽  
Amino Acid Replacement ◽  
Population Subdivision ◽  
Amino Acid Substitutions ◽  
Clinal Variation ◽  
Haplotype Structure ◽  
Common Amino Acid ◽  
Chromosome Arrangement ◽  
Dna Sequence Variation

Abstract We analyze genetic variation at fused1, a locus that is close to the centromere of the X chromosome-autosome (X/4) fusion in Drosophila americana. In contrast to other X-linked and autosomal genes, for which a lack of population subdivision in D. americana has been observed at the DNA level, we find strong haplotype structure associated with the alternative chromosomal arrangements. There are several derived fixed differences at fused1 (including one amino acid replacement) between two haplotype classes of this locus. From these results, we obtain an estimate of an age of ∼0.61 million years for the origin of the two haplotypes of the fused1 gene. Haplotypes associated with the X/4 fusion have less DNA sequence variation at fused1 than haplotypes associated with the ancestral chromosome arrangement. The X/4 haplotypes also exhibit clinal variation for the allele frequencies of the three most common amino acid replacement polymorphisms, but not for adjacent silent polymorphisms. These patterns of variation are best explained as a result of selection acting on amino acid substitutions, with geographic variation in selection pressures.

scholarly journals cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.

1994 ◽  
Vol 269 (37) ◽  
pp. 23192-23196 ◽  
Author(s):  
H. Yokota ◽  
P. Fernandez-Salguero ◽  
H. Furuya ◽  
K. Lin ◽  
O.W. McBride ◽  
...  
Keyword(s):  
Cdna Cloning ◽  
Dihydropyrimidine Dehydrogenase ◽  
Chromosome Mapping ◽  
Fluorouracil Toxicity

Interleukin-8 genetic diversity, haplotype structure and production differ in two ethnically distinct South African populations

Cytokine ◽  
2021 ◽  
pp. 155489
Author(s):  
Maria Paximadis ◽  
Anabela C.P. Picton ◽  
Dhriti Sengupta ◽  
Michele Ramsay ◽  
Adrian Puren ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
South African ◽  
Interleukin 8 ◽  
Haplotype Structure ◽  
African Populations ◽  
South African Populations

P265 HLA haplotype structure in a Chinese population

2017 ◽  
Vol 78 ◽  
pp. 249
Author(s):  
Pedro Cano ◽  
Ming Li
Keyword(s):  
Chinese Population ◽  
Haplotype Structure

scholarly journals Haplotype Structure and Divergence at Human and Chimpanzee Serotonin Transporter and Receptor Genes: Implications for Behavioral Disorder Association Analyses

2010 ◽  
Vol 27 (7) ◽  
pp. 1518-1529 ◽  
Author(s):  
K. G. Claw ◽  
R. Y. Tito ◽  
A. C. Stone ◽  
B. C. Verrelli
Keyword(s):  
Serotonin Transporter ◽  
Behavioral Disorder ◽  
Haplotype Structure ◽  
Association Analyses

Females and elderly at risk of fluorouracil toxicity

2003 ◽  
Vol &NA; (945) ◽  
pp. 4
Author(s):  
&NA;
Keyword(s):  
At Risk ◽  
Fluorouracil Toxicity
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