scholarly journals Vitamin D’s negative impact on antipsychotic drug exposure may counteract its potential benefits in schizophrenia

2022 ◽  
Author(s):  
Arnim Johannes Gaebler ◽  
Michelle Finner‐Prével ◽  
Sarah Lammertz ◽  
Sabrina Schaffrath ◽  
Patrick Eisner ◽  
...  
Keyword(s):  
Antipsychotic Drug ◽  
Drug Exposure ◽  
Negative Impact ◽  
Potential Benefits

scholarly journals The antiseptic Miramistin: a review of its comparative in vitro and clinical activity

2020 ◽  
Vol 44 (4) ◽  
pp. 399-417 ◽  
Author(s):  
Ali Osmanov ◽  
Zara Farooq ◽  
Malcolm D Richardson ◽  
David W Denning
Keyword(s):  
Soviet Union ◽  
Negative Impact ◽  
English Literature ◽  
Soviet Bloc ◽  
Clinical Activity ◽  
Good Tolerability ◽  
The Soviet Union ◽  
Potential Benefits ◽  
Low Toxicity

ABSTRACT Miramistin is a topical antiseptic with broad antimicrobial action, including activity against biofilms and a clinical profile showing good tolerability. Miramistin was developed within a framework of the Soviet Union Cold War Space Program. It is available for clinical use in several prior Soviet bloc countries, but barely known outside of these countries and there is almost no mention of miramistin in the English literature. However, considering emerging antimicrobial resistance, the significant potential of miramistin justifies its re-evaluation for use in other geographical areas and conditions. The review consists of two parts: (i) a review of the existing literature on miramistin in English, Russian and Ukrainian languages; (ii) a summary of most commonly used antiseptics as comparators of miramistin. The oral LD50 was 1200 mg/kg, 1000 mg/kg and 100 g/L in rats, mice and fish, respectively. Based on the results of the review, we suggest possible applications of miramistin and potential benefits over currently used agents. Miramistin offers a novel, low toxicity antiseptic with many potential clinical uses that need better study which could address some of the negative impact of antimicrobial, antiseptic and disinfectant resistance.

Futility and appropriateness: challenging words, important concepts

2018 ◽  
Vol 94 (1110) ◽  
pp. 238-243 ◽  
Author(s):  
D Robin Taylor ◽  
Calvin J Lightbody
Keyword(s):  
Professional Training ◽  
Moral Distress ◽  
Negative Impact ◽  
Medical Model ◽  
Curative Intent ◽  
High Expectations ◽  
Resource Limitations ◽  
Potential Benefits ◽  
Perfect Storm

The provision of healthcare is being challenged by a ‘perfect storm’ of forces including an increasing population with multiple comorbidities, high expectations and resource limitations, and in the background, the pre-eminence of the ‘curative medical model’. Non-beneficial (futile) treatments are wasteful and costly. They have a negative impact on quality of life especially in the last year of life. Among professionals, frequent encounters with futility cause moral distress and demoralisation. The factors that drive non-beneficial treatments include personal biases, patient-related pressures and institutional imperatives. Breaking loose from the perceived necessity to deliver non-beneficial treatment is a major challenge. Curative intent should give way to appropriateness such that curative and palliative interventions are valued equally. Goals of treatment should be shaped by illness trajectory, the risk of harms as well as potential benefits and patient preferences. This strategy should be reflected in professional training and the design of acute services.

Change management overlooked: physician perspectives on EHR implementation

2019 ◽  
Vol 34 (1) ◽  
pp. 19-36
Author(s):  
Michele Heath ◽  
Tracy H. Porter
Keyword(s):  
Human Factors ◽  
Change Management ◽  
Change Process ◽  
Negative Impact ◽  
Structured Interviews ◽  
Healthcare Organizations ◽  
Content Type ◽  
Physician Perspectives ◽  
Potential Benefits ◽  
Physician Resistance

PurposeThe purpose of this paper is to gain understanding into the human factors which might impede the change process. Change is inevitable in contemporary organizations and particularly within the healthcare field with respect to information technology (IT). Regardless of the amount of literature surrounding change management process organizational leaders will often ignore the human factors associated with the introduction of new IT.Design/methodology/approachThis study sought to examine physician resistance surrounding the Electronic health record (EHR) change process through the lens of each of these three aspects of the Bovey and Hede (2001a) model through semi-structured interviews with physicians. Semi-structured interviews were conducted with physicians from hospitals within the Midwest.FindingsThe findings suggest that physicians have been impacted by the EHR change management system within their hospitals. Though each of the participants experienced different issues; it was clear from the data the change to an EHR system was disruptive to their day-to-day routines and caused various challenges. EHR change management research demonstrates physicians are resisting the change despite recognizing its potential benefits.Originality/valueThis paper contributes to the change management literature by examining how physician resistance can have a negative impact on healthcare organizations during a precipitous technology change. The study also provides a unique understanding of how technology resistance can disrupt an organizational change process.

Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure

1999 ◽  
Vol 46 (2) ◽  
pp. 161-172 ◽  
Author(s):  
Lynn D. Selemon ◽  
Michael S. Lidow ◽  
Patricia S. Goldman-Rakic
Keyword(s):  
Prefrontal Cortex ◽  
Antipsychotic Drug ◽  
Drug Exposure

Antipsychotic Drug Exposure in a Health Maintenance Organization

Medical Care ◽  
1993 ◽  
Vol 31 (5) ◽  
pp. 432-444 ◽  
Author(s):  
RICHARD E. JOHNSON ◽  
BENTSON H. MCFARLAND
Keyword(s):  
Antipsychotic Drug ◽  
Drug Exposure ◽  
Health Maintenance Organization ◽  
Health Maintenance

Inferred Brain Cell-Type Shifts Accompany Schizophrenia and Bipolar Disorder and Differentially Correlate With Antipsychotic Drug Exposure

2021 ◽  
Vol 89 (9) ◽  
pp. S118-S119
Author(s):  
Anton Schulmann ◽  
Stefano Marenco ◽  
Nirmala Akula ◽  
Pavan Auluck ◽  
Barbara Lipska ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Antipsychotic Drug ◽  
Drug Exposure ◽  
Brain Cell ◽  
Cell Type

scholarly journals Going "Green" in the Delivery and Supply Chain: Evidence and Insights

2019 ◽  
Vol 20 (2) ◽  
Author(s):  
Paxton Victoria Shamlou ◽  
Asoo J. Vakharia
Keyword(s):  
Power Generation ◽  
Supply Chain ◽  
Co2 Emissions ◽  
Negative Impact ◽  
Consumer Products ◽  
Generation Process ◽  
Financial Outcomes ◽  
Consumer Interest ◽  
Electric Cars ◽  
Potential Benefits

 Given increased consumer interest in green products and practices, this paper will focus on examining sustainable practices within the shipping, packaging and delivery supply chain.  “Green” shipping, packaging, and delivery focuses on transporting products from providers (e.g., manufacturers, retailers) to customers to reduce CO2 emissions, landfill waste, and overall negative impact to the environment. For example, (a) the use of electric powered vehicles in the delivery supply chain has the potential to reduce CO2 emissions; and (b) using recycled cardboard or materials that are biodegradable would reduce landfill waste. This paper examines the potential benefits of these green practices in the delivery supply chain.  Our results are that a case can be made for use of electric-power vehicles and their potential benefit to reduce CO2 emissions in an environment where power generation in non-coal based.  In other words, using electric cars in all delivery supply chains isn’t always a solution; firms must recognize the significant impact of the power generation process in their operating area.   From a packaging perspective, there is documented consumer interest on using environmentally friendly material for consumer products.  However, depending upon the market segment size, this might not always result in better financial outcomes for companies. 

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